Abstract: The present invention relates to epitopes containing homocitrulline (Hcit) that can be used as targets for cancer immunotherapy. The homocitrullinated T cell epitope has (i) a predicted binding score to MHC class II or class I of <30 using the online IEDB prediction program (http://www.iedb.org/) and (ii) at least 5 consecutive amino acids that form a spiral conformational structure. These modified peptides can be used as vaccines or as targets for T cell receptor (TCR) and adoptive T cell transfer therapies.

Abstract: Various embodiments provide a standardized way to interact with and extend instant messaging applications. A platform is provided and enables developers and other third parties to create extensions for instant messaging applications. Through a set of APIs, interacting applications or plug-ins are “sandboxed” in their own areas where they are unable to perform unpermitted or unauthorized actions. The plug-in platform or architecture is integrated with the platform of the instant messaging application and can allow developers to create plug-ins that can interact with a local user and their buddies. Any number of various types of plug-ins can be developed and incorporated into the instant messaging application in a standardized manner.