Patents by Inventor Wenhua Gao

Wenhua Gao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240131086
    Abstract: The present disclosure provides use of Clostridium ghonii combined with a tumor angiogenesis inhibitor in preparing a pharmaceutical product for treating a tumor. The present disclosure further provides a drug for treating a tumor, where the drug includes active ingredients of Clostridium ghonii and a tumor angiogenesis inhibitor.
    Type: Application
    Filed: October 9, 2022
    Publication date: April 25, 2024
    Inventors: Yong Wang, Yuanyuan Liu, Wenhua Zhang, Yanqiu Xing, Shaopeng Wang, Dan Wang, Hong Zhu, Xinglu Xu, Shengbiao Jiang, Xiaonan Li, Jiahui Zheng, Rong Zhang, Dongxia Yang, Yuxia Gao, Shili Shao, Ting Han
  • Publication number: 20240115627
    Abstract: The present disclosure relates to use of a Clostridium ghonii spore combined with pembrolizumab in cancer treatment. It is found for the first time that the Clostridium ghonii spore combined with pembrolizumab can significantly improve a curative effect of colon cancer and reduce a dose of the pembrolizumab, and thus is efficient and low-toxic. Oncolysis by Clostridium ghonii can affect immunogenicity of a tumor microenvironment (TME) by various ways, converts an immunosuppressive state of the TME into an immune-activated state, adjusts the immunosuppressive TME, and breaks an immune tolerance. An optimal combination of the Clostridium ghonii spore and the pembrolizumab thoroughly removes about 20% of mouse tumor tissues. A benefit range of patients with tumors treated by a PD-1 antibody is expanded. The combination even has an obvious curative effect on patients failed the treatment by the PD-1 antibody.
    Type: Application
    Filed: October 9, 2022
    Publication date: April 11, 2024
    Inventors: Yong Wang, Hong Zhu, Wenhua Zhang, Yanqiu Xing, Dan Wang, Yuanyuan Liu, Shaopeng Wang, Jiahui Zheng, Rong Zhang, Xiaonan Li, Xinglu Xu, Shengbiao Jiang, Lichao Xing, Yuxia Gao, Shili Shao, Ting Han
  • Patent number: 11805578
    Abstract: The disclosure discloses a microwave processing equipment for continuous flow liquids, and belongs to the technical field of microwave processing. The microwave processing equipment includes a feed preheating section, a microwave heating section and a cooling section. The microwave heating section includes a microwave generation system, a waveguide system, tuners, and a microwave absorption cavity. The waveguide system includes at least two waveguides. Each waveguide is installed at the microwave feed port formed in the outer wall of the microwave absorption cavity according to a predetermined angle greater than or equal to 15° and less than 90°.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: October 31, 2023
    Assignees: JIANGNAN UNIVERSITY, NANJING XIANOU INSTRUMENTS MANUFACTURE CO., LTD
    Inventors: Daming Fan, Wenhua Gao, Huayu Yang, Hao Zhang, Bowen Yan, Yuhao Zhang, Jianxin Zhao, Wei Chen
  • Publication number: 20230015265
    Abstract: A vibration apparatus comprising: a vibration assembly comprising a counterweight block, a first magnet group and an elastic member, the first magnet group is fixed on the counterweight block, the vibration assembly is suspended in the vibration apparatus through the elastic member; a stator assembly comprising a coil and a second magnet group, the second magnet group is installed in a winding hole of the coil; the first magnet group comprises at least two side magnets, magnetization directions of the two side magnets are perpendicular to a plane on which the coil is located, the side magnets are magnetized in opposite directions, a magnetization direction of the second magnet group is parallel to the plane, two poles of second magnet group are respectively attracted to poles of side magnets adjacent to the coil, the vibration assembly is configured to produce vibration relative to the stator assembly.
    Type: Application
    Filed: December 5, 2020
    Publication date: January 19, 2023
    Inventors: Dezhang SHI, Dongsheng MAO, Zhiming GAO, Wenhua GAO
  • Patent number: 11554529
    Abstract: Disclosed are 3D printing equipment, a system, and a method for food design and production. The 3D printing equipment has a bipolar microwave heating antenna for focusing heating on a material in an extrusion nozzle. The extrusion nozzle is between the anode antenna and the cathode antenna of the bipolar microwave heating antenna. The anode antenna and the cathode antenna limit a microwave electric field between them, thereby implementing focused heating on the material.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: January 17, 2023
    Assignee: Jiangnan University
    Inventors: Daming Fan, Zilong Zhao, Bowen Yan, Wenhua Gao, Jianlian Huang, Huayu Yang, Hao Zhang, Jianxin Zhao, Wei Chen
  • Patent number: 11116247
    Abstract: The disclosure relates to a three-dimensional printer coupled with microwave and a printing method applied for food design. A microwave heating probe embedded in the inner wall of a barrel releases microwaves at the front end, and in combination with the setting of a vertical distance between the front end of the microwave heating probe and an extrusion nozzle, the effect of instant curing of an extruded material is realized. A cooling device is disposed so as to ensure that a material to be printed in the barrel is not cured by microwave heating before the material to be printed enters the extrusion nozzle.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: September 14, 2021
    Assignee: JIANGNAN UNIVERSITY
    Inventors: Daming Fan, Zilong Zhao, Liming Jin, Bowen Yan, Hao Zhang, Wenhua Gao, Hongwei Cao, Huayu Yang, Jianxin Zhao, Wei Chen
  • Publication number: 20210112845
    Abstract: The disclosure discloses a three-dimensional printer coupled with microwave and printing method applied for food design, and belongs to the technical field of food.
    Type: Application
    Filed: December 8, 2020
    Publication date: April 22, 2021
    Inventors: Daming FAN, Zilong ZHAO, Liming JIN, Bowen YAN, Hao ZHANG, Wenhua GAO, Hongwei CAO, Huayu YANG, Jianxin ZHAO, Wei CHEN
  • Publication number: 20210008787
    Abstract: Disclosed are 3D printing equipment, a system, and a method for food design and production, belonging to the field of food technologies. A bipolar microwave heating antenna is disposed, to implement focused heating on a material in an extrusion nozzle. In addition, the bipolar microwave heating antenna breaks through a traditional multi-mode cavity heating method, thereby greatly reducing a volume of a heating cavity and facilitating integration with a desktop 3D printer. A microwave switch is controlled by using an extrusion instruction to achieve synchronization between extrusion and heating, and improve heating uniformity. Through joint operations of a 3D scanner, slicing software, and a 3D printer, processes of model making, slicing, and 3D printing are integrated.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 14, 2021
    Inventors: Daming FAN, Zilong ZHAO, Bowen YAN, Wenhua GAO, Jianlian HUANG, Huayu YANG, Hao ZHANG, Jianxin ZHAO, Wei CHEN
  • Publication number: 20200374994
    Abstract: The disclosure discloses a microwave processing equipment for continuous flow liquids, and belongs to the technical field of microwave processing. The microwave processing equipment for continuous flow liquids of the disclosure includes a feed preheating section, a microwave heating section and a cooling section. The microwave heating section includes a microwave generation system, a waveguide system, tuners, and a microwave absorption cavity. The waveguide system includes at least two waveguides. Each waveguide is installed at the microwave feed port formed in the outer wall of the microwave absorption cavity according to a predetermined angle. The predetermined angle is greater than or equal to 15° and less than 90°. The disclosure provides a specific implementation scheme for microwave processing of flow liquids. In consideration of the reflection action of microwaves, the safety of equipment operation process and the utilization rate of energy are improved by a special waveguide arrangement mode.
    Type: Application
    Filed: August 10, 2020
    Publication date: November 26, 2020
    Inventors: Daming FAN, Wenhua GAO, Huayu YANG, Hao ZHANG, Bowen YAN, Yuhao ZHANG, Jianxin ZHAO, Wei CHEN
  • Patent number: 9099974
    Abstract: Exemplary systems and methods enable a user of a mobile device that is communicatively coupled to a remote device to adjust the audio output volume level of an application running on the remote device using audio volume adjustment inputs on the mobile device. The application produces an audio output signal that has an adjustable audio volume output level. The mobile device receives the audio output signal from the remote device. The mobile device detects an audio volume adjustment input. The mobile device redirects the audio volume adjustment to the remote device to control the audio output volume level of the application.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: August 4, 2015
    Assignee: VMware, Inc.
    Inventors: Wenhua Gao, Shuhua Wang, Peng Guo, An Min Gong, Jian Ken Song
  • Publication number: 20150180432
    Abstract: Exemplary systems and methods enable a user of a mobile device that is communicatively coupled to a remote device to adjust the audio output volume level of an application running on the remote device using audio volume adjustment inputs on the mobile device. The application produces an audio output signal that has an adjustable audio volume output level. The mobile device receives the audio output signal from the remote device. The mobile device detects an audio volume adjustment input. The mobile device redirects the audio volume adjustment to the remote device to control the audio output volume level of the application.
    Type: Application
    Filed: December 20, 2013
    Publication date: June 25, 2015
    Applicant: VMware, Inc.
    Inventors: Wenhua GAO, Shuhua WANG, Peng GUO, An Min GONG, Jian Ken SONG
  • Patent number: 7303887
    Abstract: A HECT-domain containing E3 ubiquitin ligase that mediates the polyubiquitination of Mcl-1, named Mule for Mcl-1 ubiquitin ligase E3, is described. Methods and compositions for modulating functional interaction between Mcl-1 and Mule protein and Mcl-1 mediated apoptosis are described. Diagnostic and prognostic methods based on Mule expression in patient cells are also described.
    Type: Grant
    Filed: May 18, 2005
    Date of Patent: December 4, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Xiaodong Wang, Qing Zhong, Wenhua Gao, Fenghe Du
  • Publication number: 20060264366
    Abstract: A HECT-domain containing E3 ubiquitin ligase that mediates the polyubiquitination of Mcl-1, named Mule for Mcl-1 ubiquitin ligase E3, is described. Methods and compositions for modulating functional interaction between Mcl-1 and Mule protein and Mcl-1 mediated apoptosis are described. Diagnostic and prognostic methods based on Mule expression in patient cells are also described.
    Type: Application
    Filed: May 18, 2005
    Publication date: November 23, 2006
    Inventors: Xiaodong Wang, Qing Zhong, Wenhua Gao, Fenghe Du