Abstract: Novel 5? untranslated region (UTR)-targeting gene knock-in (KI) compositions and methods of use are disclosed. The gene KI compositions and methods exploit homology-independent targeted integration (HITI)-mediated insertion of a wild-type coding sequence (CDS) into the 5? UTR upstream of a translation initiation element of a mutated variant of the wild-type gene. The 5? UTR-targeting gene KI therapy compositions and methods provide safer and more efficient gene insertion compared to other gene therapy approaches.

Abstract: Embodiments of the present disclosure provide a signal acquisition circuit. The signal acquisition circuit includes a differential amplifier, a first electrode, a second electrode, a first negative capacitance circuit, and a second negative capacitance circuit. The first electrode is connected to a first input terminal of the differential amplifier through a first lead, and the second electrode is connected to a second input terminal of the differential amplifier through a second lead. The first negative capacitance circuit is electrically connected to the first lead and ground, and the second negative capacitance circuit is electrically connected to the second lead and the ground. Both the first negative capacitance circuit and the second negative capacitance circuit exhibit a negative capacitance effect.

Abstract: The present disclosure provides a microphone, comprising a shell structure, a vibration pickup assembly, a vibration pickup assembly, wherein the vibration pickup assembly is accommodated in the shell structure and generates vibration in response to an external sound signal transmitted to the shell structure, and at least two acoustoelectric conversion elements configured to respectively receive the vibration of the vibration pickup assembly to generate an electrical signal, wherein the at least two acoustoelectric conversion elements have different frequency responses to the vibration of the vibration pickup assembly.

Abstract: A display substrate includes a plurality of data lines and a plurality of columns of pixel driving circuits. A column of pixel driving circuits is connected to a corresponding data line, and each pixel driving circuit includes a driving transistor and a first transistor. The driving transistor is a P-type transistor. The first transistor includes: a first active pattern having a first channel region, and a first doped region and a second doped region on two opposite sides of the first channel region; a first gate; and a first insulating block disposed on a side of the first active pattern away from the base and having a first via. The data line is connected to a portion of the first active pattern located in the first doped region through the first via. Sizes of all first vias in the column of pixel driving circuits gradually decrease in a first direction.

Abstract: A pixel circuit includes sub-pixel circuits each including a reset sub-circuit, a driving sub-circuit, and a light-emitting device. The reset sub-circuit is configured to input a voltage provided by an initial voltage terminal to the driving sub-circuit under control of a signal from a first reset control terminal. The driving sub-circuit is configured to control a driving current flowing through the light-emitting device according to a data signal output by a data terminal. The sub-pixel circuits include first and second sub-pixel circuits that are located in two adjacent columns, and connected to a same data terminal. A first reset control terminal and a writing control terminal of the first sub-pixel circuit are connected to first and second scanning signal terminals. A first reset control terminal and a writing control terminal of the second sub-pixel circuit are connected to second and third scanning signal terminals.

Abstract: This disclosure provides methods and systems that adaptively adjust the gain of the drive signal to a slow-scan mirror to compensate and stabilize the mirror to achieve desired performance metrics. Non-ideal characteristics of the slow-scan mirror, including the mirror and related assembly, exhibit behaviors that impact the overall gain of the device, which changes over time and operating environment. To compensate for these non-ideal characteristics, the drive signal to the slow-scan mirror may need to be adjusted to achieve the desired beam deflection angle. An adaptive inner loop gain control structure may be employed to dynamically adjust the gain of the inner-control loop to achieve a target gain such that the overall gain variations from the slow scan mirror and other components are scan mirror such that compensated and stabilized. The parameters, logic and blocks of the inner loop gain control may be implemented in hardware, software, or combinations thereof.

Abstract: The configuring of a micromirror to suppress a resonance of the micromirror. As part of the configuring process, the micromirror is subjected to multiple actuation frequencies, and the micromirror response is measured in response to at least some of these actuation frequencies. A resonant frequency of the micromirror is then determined using at least some of the measured mechanical responses. Then, depending on this determined resonant frequency of the micromirror, notch filter parameters are selected. There is more than one possibility for notch filter parameters, where the selected possibility depends on the determined resonant frequency. The notch filter is then configured with the selected notch filter parameters.

Abstract: A laser beam scanning (“LBS”) display device is configured with an optical system that includes a laser beam emitter configured to emit a laser beam. The optical system also includes a driver configured to generate a driving signal for controlling a mirror, such as a microelectromechanical systems (“MEMS”) mirror. The optical system also includes a controller configured to generate a driving signal while rejecting a system disturbance response.

Abstract: Techniques are described herein that are capable of adjusting a center frequency of an adaptive voltage controlled oscillator (VCO) that is included in an adaptive phase lock loop (PLL) and/or a phase difference target of the adaptive PLL. An adaptive PLL is a PLL that includes an adaptive VCO. An adaptive VCO is a VCO that is capable of adjusting its center frequency and/or a phase difference target of the adaptive PLL that includes the adaptive VCO. The adaptive PLL may be configured to drive (e.g., control) a device. A drive signal that is used to drive the device and a resulting output signal that is proportional to movement of the device may be fed back to respective inputs of the adaptive PLL so that the phases of those signals may be processed to facilitate adjustment of the center frequency and/or the phase difference target.

Abstract: A laser beam scanning (“LBS”) display device is configured with an optical system that includes a laser beam emitter configured to emit a laser beam. The optical system also includes a driver configured to generate a driving signal for controlling a mirror, such as a microelectromechanical systems (“MEMS”) mirror. The optical system also includes a controller configured to generate a driving signal while rejecting a system disturbance response.

Abstract: A laser beam display device that can dynamically control the resonant frequency of a mirror is provided. The increase the reliability of a device by controlling the resonant frequency of a mirror instead of requiring components of a display device to react to changes in the resonant frequency of a mirror. A controller can drive a mirror with an input signal, receive a signal or data indicating a target resonant frequency, and bias the input signal to control the resonant frequency of the mirror. In some embodiments, the controller can also receive a feedback signal from a mirror indicating a current resonant frequency. The controller can also bias the input signal to increase or decrease the current resonant frequency. By dynamically controlling the resonant frequency of a mirror, a device can minimize any difference between the current resonant frequency detected in a feedback signal and the target resonant frequency.

Abstract: This disclosure provides methods and systems that adaptively adjust the gain of the drive signal to a slow-scan mirror to compensate and stabilize the mirror to achieve desired performance metrics. Non-ideal characteristics of the slow-scan mirror, including the mirror and related assembly, exhibit behaviors that impact the overall gain of the device, which changes over time and operating environment. To compensate for these non-ideal characteristics, the drive signal to the slow-scan mirror may need to be adjusted to achieve the desired beam deflection angle. An adaptive inner loop gain control structure may be employed to dynamically adjust the gain of the inner-control loop to achieve a target gain such that the overall gain variations from the slow scan mirror and other components are scan mirror such that compensated and stabilized. The parameters, logic and blocks of the inner loop gain control may be implemented in hardware, software, or combinations thereof.

Abstract: A display panel includes a base substrate, a display area and a non-display area provided on the base substrate; a data line is provided in the display area and a detection line is provided in the non-display area on the base substrate; and the detection line is electrically connected to a data line and is formed by overlapping a plurality of wire segments. A method of manufacturing a display panel, and a display device are further disclosed.

Abstract: Techniques are described herein that are capable of adjusting a center frequency of an adaptive voltage controlled oscillator (VCO) that is included in an adaptive phase lock loop (PLL) and/or a phase difference target of the adaptive PLL. An adaptive PLL is a PLL that includes an adaptive VCO. An adaptive VCO is a VCO that is capable of adjusting its center frequency and/or a phase difference target of the adaptive PLL that includes the adaptive VCO. The adaptive PLL may be configured to drive (e.g., control) a device. A drive signal that is used to drive the device and a resulting output signal that is proportional to movement of the device may be fed back to respective inputs of the adaptive PLL so that the phases of those signals may be processed to facilitate adjustment of the center frequency and/or the phase difference target.

Abstract: The techniques disclosed herein provide apparatus, methods and systems that adaptively adjust the signal waveform (or waveshape) of the drive signal to a slow-scan mirror to compensate for non-linearities observed in the slow-scan feedback signal from a slow-scan mirror. Over large scan angles and high temperatures, the slow-scan mirror in a laser beam scanning device may exhibit a nonlinear response to the drive signal that results in poor image quality issues such as bright lines, bands in the display image, and image distortion. The presently disclosed technologies track the linearity performance of the overall system by detecting non-linearities in waveform of the slow-scan feedback signal real time, and consequently apply a pre-distortion to the drive waveform to compensate for these detected non-linearities. The parameters, logic and blocks of the control may be implemented in hardware, software or combinations thereof.

Abstract: The present disclosure provides a method for manufacturing an array substrate, an array substrate, and a display device. By first forming holes in a first thin film transistor, then simultaneously performing hydrogen supplementation on the first thin film transistor and a second thin film transistor, and then forming holes in the second thin film transistor, the first thin film transistor and the second thin film transistor can be repaired and compensated in different degrees by hydrogen supplementation.

Abstract: A display device, including a display surface, a laser beam emitter, and a processor. The display device may further include a slow-scan MEMS driver configured to drive a slow-scan mirror and a fast-scan MEMS driver configured to drive a fast-scan mirror. The slow-scan mirror and the fast-scan mirror may reflect the laser beam onto an active region of the display surface. The slow-scan period may include a scanning interval in which the slow-scan mirror is configured to move to a final scanning position at one or more scanning ramp rates and a flyback interval in which the slow-scan mirror is configured to return to the initial scanning position. The processor may generate a modified slow-scan drive signal by modifying one or more of the initial scanning position, the final scanning position, and the scanning ramp rate in a blank region of the display surface.

Abstract: A pixel circuit includes sub-pixel circuits each including a reset sub-circuit, a driving sub-circuit, and a light-emitting device. The reset sub-circuit is configured to input a voltage provided by an initial voltage terminal to the driving sub-circuit under control of a signal from a first reset control terminal. The driving sub-circuit is configured to control a driving current flowing through the light-emitting device according to a data signal output by a data terminal. The sub-pixel circuits include first and second sub-pixel circuits that are located in two adjacent columns, and connected to a same data terminal. A first reset control terminal and a writing control terminal of the first sub-pixel circuit are connected to first and second scanning signal terminals. A first reset control terminal and a writing control terminal of the second sub-pixel circuit are connected to second and third scanning signal terminals.

Abstract: Techniques are described herein that are capable of adjusting a center frequency of an adaptive voltage controlled oscillator (VCO) that is included in an adaptive phase lock loop (PLL) and/or a phase difference target of the adaptive PLL. An adaptive PLL is a PLL that includes an adaptive VCO. An adaptive VCO is a VCO that is capable of adjusting its center frequency and/or a phase difference target of the adaptive PLL that includes the adaptive VCO. The adaptive PLL may be configured to drive (e.g., control) a device. A drive signal that is used to drive the device and a resulting output signal that is proportional to movement of the device may be fed back to respective inputs of the adaptive PLL so that the phases of those signals may be processed to facilitate adjustment of the center frequency and/or the phase difference target.

Abstract: A display panel, a display device and a detection method are provided. The display panel includes a display area and a peripheral area surrounding the display area. Pixel units arranged in an array are disposed in the display area. The pixel unit includes a pixel driving circuit. A crack detecting line is disposed in the peripheral area, and the crack detecting line is connected to a reset signal terminal of the pixel driving circuit of at least one pixel unit. The display panel can reduce the influence of the voltage drop over the crack detection line on the brightness during the electrical detection stage, and can also improve the crack detection rate of the peripheral area.