Patents by Inventor Wenli Ma

Wenli Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides as tubulin polymerization inhibitors
    Patent number: 8410163
    Abstract: Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: April 2, 2013
    Assignee: Telik, Inc.
    Inventors: Paul P. Beroza, Komath V. Damodaran, Stella Lui, Wenli Ma, Zhuo Wang, Hua Xu
  • SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBONITRILES AND SUBSTITUTED 4-AMINO-5-BENZOYL-2-(PHENYLAMINO)THIOPHENE-3-CARBOXAMIDES AS TUBULIN POLYMERIZATION INHIBITORS
    Publication number: 20120101286
    Abstract: Substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carbonitriles and substituted 4-amino-5-benzoyl-2-(phenylamino)thiophene-3-carboxamides and their salts are tubulin polymerization inhibitors, useful in the treatment of cancer.
    Type: Application
    Filed: February 9, 2010
    Publication date: April 26, 2012
    Applicant: TELIK INC.
    Inventors: Paul P. Beroza, Komath V. Damodaran, Stella Lui, Wenli Ma, Zhuo Wang, Hua Xu
  • Sulfonylethyl phosphorodiamidates
    Patent number: 8093231
    Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Grant
    Filed: July 17, 2007
    Date of Patent: January 10, 2012
    Assignee: Telik, Inc.
    Inventors: David R. Allen, Wenli Ma, Brian T. Peterson, Louise Robinson, Steven R. Schow, Songyuan Shi, Reyna J. Simon, Kevin T. Weber, Michael M. Wick
  • 2-{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
    Patent number: 7872134
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 18, 2011
    Assignee: Telik, Inc.
    Inventors: Edgardo Laborde, Andrew B. Kelson, Wenli Ma, Kevin T. Weber
  • 2{[2-(substituted amino)ethyl]sulfonyl}ethyl N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
    Patent number: 7655799
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N?,N?-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Grant
    Filed: November 29, 2006
    Date of Patent: February 2, 2010
    Assignee: Telik, Inc.
    Inventors: Wenli Ma, Kevin T. Weber, Robert M. Yee
  • 2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates
    Publication number: 20090156559
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer and autoimmune diseases, alone and in combination with other therapies.
    Type: Application
    Filed: December 12, 2007
    Publication date: June 18, 2009
    Inventors: Edgardo Laborde, Andrew B. Kelson, Wenli Ma, Kevin T. Weber
  • 2-ETHYL N,N,N',N'-tetrakis(2-chloroethyl)phosphorodiamidates
    Publication number: 20080125398
    Abstract: 2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N,N?,N?-tetrakis(2-chloroethyl)-phosphorodiamidates, their preparation and intermediates in their preparation, pharmaceutical compositions containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Application
    Filed: November 29, 2006
    Publication date: May 29, 2008
    Inventors: Wenli Ma, Kevin T. Weber, Robert M. Yee
  • 2 (SULFONYL)ETHYL N,N,N',N' tetrakis(2 chloroethyl)phosphorodia
    Publication number: 20080125397
    Abstract: 2-({2-Oxo-2-[(pyridin-3-ylmethyl)amino]ethyl}sulfonyl)ethyl N,N,N?,N?-tetrakis(2-chloroethyl)phosphorodiamidate and its acid addition salts, especially in solid form, their preparation and intermediates in their preparation, formulations containing them, and methods of treatment using them. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 29, 2008
    Inventors: Stella K. Lui, Wenli Ma, Robert M. Yee
  • SULFONYLETHYL PHOSPHORODIAMIDATES
    Publication number: 20080039429
    Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Application
    Filed: July 17, 2007
    Publication date: February 14, 2008
    Inventors: David Allen, Wenli Ma, Brian Peterson, Louise Robinson, Steven Schow, Songyuan Shi, Reyna Simon, Kevin Weber, Michael Wick
  • Sulfonylethyl phosphorodiamidates
    Publication number: 20050267075
    Abstract: Sulfonylethyl and thioethyl phosphorodiamidates, their preparation and intermediates in their preparation, formulations containing them, and their pharmaceutical use. The compounds are useful for treating cancer, alone and in combination with other anticancer therapies.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 1, 2005
    Inventors: David Allen, Wenli Ma, Brian Peterson, Louise Robinson, Steven Schow, Songyuan Shi, Reyna Simon, Kevin Weber, Michael Wick
  • Antagonist of MCP-1 function, and compositions and methods of use thereof
    Patent number: 6962926
    Abstract: Compounds of formula A and formula B: and their pharmaceutically acceptable salts, compositions comprising them, methods for their use, and their use in the preparation of medicaments. The compounds are antagonists of MCP-1 function, and are useful in the prevention and treatment of chronic or acute inflammatory or autoimmune diseases, such as multiple sclerosis, and in the prevention and treatment of allergic hypersensitivity disorders.
    Type: Grant
    Filed: August 8, 2003
    Date of Patent: November 8, 2005
    Assignees: Telik, Inc., Sanwa Kagaku Kenkyusho Co., Ltd.
    Inventors: Edgardo Laborde, Louise Robinson, Fanying Meng, Brian T. Peterson, Hugo O. Villar, Steven E. Anuskiewicz, Wenli Ma, Yukiharu Matsumoto, Kunihisa Baba, Hideaki Inagaki, Katsumasa Tanaka, Yoshiro Ishiwata, Shoji Yokochi, Masayuki Okamoto, Takashi Nakamura, Atsushi Miyachi, Mitsuaki Takeuchi, Kouji Matsushima
  • Antagonist of MCP-1 function, and compositions and methods of use thereof
    Publication number: 20040198719
    Abstract: Compounds of formula A and formula B: 1
    Type: Application
    Filed: August 8, 2003
    Publication date: October 7, 2004
    Inventors: Edgardo Laborde, Louise M. Robinson, Fanying Meng, Brian T. Peterson, Hugo O. Villar, Steven E. Anuskiewicz, Wenli Ma, Yukiharu Matsumoto, Kunihisa Baba, Hideaki Inagaki, Katsumasa Tanaka, Yoshiro Ishiwata, Shoji Yokochi, Masayuki Okamoto, Takashi Nakamura, Atsushi Miyachi, Mitsuaki Takeuchi, Kouji Matsushima