Abstract: The present invention is related to location positioning systems, and more particularly, to a method and apparatus for providing reliable extended ephemeris information and indicators of quality. According to one aspect, the invention employs a concept of Approximate Accuracy Symmetry, in which a history of broadcast ephemerides is logged for each satellite, and used as a reference to evaluate the potential accuracy of the predicted orbit for each satellite in the future. According to further aspects, the desired accuracy information for the extended ephemerides can be reliably provided in advance.

Abstract: Provided herein are methods and systems for efficient communication between a server and a client in an assisted navigation system. In one or more embodiments, the client, e.g., a GPS receiver, receives a set of parameters for a satellite from the server via a wireless or wired connection. The set of parameters includes a force parameter, initial condition parameters and time correction coefficients for the satellite. The receiver uses the received parameters in a numerical integration to compute the position of the satellite at a desired time. The set of parameters needed for the integration is small compared to current methods which require sending more data to the client. Thus these parameters require less communication resources to transmit. To further reduce the amount of data that needs to be transmitted, reference parameters may be subtracted from the original parameters before transmission from the server.

Abstract: The invention provides methods of treating cancer with a compound which inhibits kinases, more specifically IGF1R and Abl, in combination with treatments(s) selected from surgery, radiation, monoclonal antibody, bone marrow or peripheral blood stem cell transplantation, and one or more chemotherapeutic agent(s).

Abstract: The present invention provides methods and systems that enable a mobile navigation receiver to accurately determine its trajectory with non-current ephemeris in stand-alone mode. In an embodiment, the receiver computes the position for the same location using non-current ephemeris and current ephemeris at different time instances. The receiver then determines a position correction by finding the difference between these two computed positions, and applies this correction to the trajectory generated with non-current ephemeris to obtain a more accurate trajectory. In another embodiment, the receiver computes an initial position of the receiver using non-current ephemeris and finds the difference between the computed initial position and an accurate approximation of the initial position. The receiver then shifts the subsequent receiver trajectory computed using non-current ephemeris by the difference to obtain a more accurate trajectory.

Abstract: The present invention provides methods and systems that enable a mobile navigation receiver to accurately determine its trajectory with non-current ephemeris in stand-alone mode. In an embodiment, the receiver computes the position for the same location using non-current ephemeris and current ephemeris at different time instances. The receiver then determines a position correction by finding the difference between these two computed positions, and applies this correction to the trajectory generated with non-current ephemeris to obtain a more accurate trajectory. In another embodiment, the receiver computes an initial position of the receiver using non-current ephemeris and finds the difference between the computed initial position and an accurate approximation of the initial position. The receiver then shifts the subsequent receiver trajectory computed using non-current ephemeris by the difference to obtain a more accurate trajectory.

Abstract: The invention provides compounds and methods for inhibition of kinases, such as those of the TAO family, more specifically KIAA1361, TAO, and JIK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity.

Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity.

Abstract: The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity.