Patents by Inventor Wenwu Xiao

Wenwu Xiao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDES FOR ACTIVATION OF CELL SIGNALING IN OSTEOPROGENITOR CELLS
    Publication number: 20210395302
    Abstract: The present invention provides compounds and pharmaceutical compositions of peptidomimetic ligands. The peptidomimetic ligands can be conjugated with phosphonate drugs. The compounds and pharmaceutical compositions of the present invention are useful in the treatment of osteoporosis and for the promotion of bone growth due to their specificity for the ?4?1 integrin on mesenchymal stem cells and for the surface of bone.
    Type: Application
    Filed: January 11, 2021
    Publication date: December 23, 2021
    Applicant: The Regents of the University of California
    Inventors: Wei YAO, Ruiwu LIU, Kit S. LAM, Wenwu XIAO, Nancy LANE
  • RGD-CONTAINING CYCLIC PEPTIDES
    Publication number: 20160017000
    Abstract: The present invention is drawn to cyclic RGD peptides linked via a disulfide bond, where the terminal cysteines are preferably in the D configuration. These peptides target ?v?3 integrin on tumor cells and neovasculatures and function as targeting agents for tumor diagnostic imaging and therapy. Compared with the commonly used RGD ligands, compounds of the present invention have improved targeting efficacy and lower nonspecific binding to normal organs. Moreover, the compounds of the present invention can be functionalized to conjugate imaging payload without decreasing binding strength.
    Type: Application
    Filed: June 30, 2015
    Publication date: January 21, 2016
    Inventors: Kit S. Lam, Yan Wang, Wenwu Xiao
  • RGD-containing cyclic peptides
    Patent number: 9073974
    Abstract: The present invention is drawn to cyclic RGD peptides linked via a disulfide bond, where the terminal cysteines are preferably in the D configuration. These peptides target ?v?3 integrin on tumor cells and neovasculatures and function as targeting agents for tumor diagnostic imaging and therapy. Compared with the commonly used RGD ligands, compounds of the present invention have improved targeting efficacy and lower nonspecific binding to normal organs. Moreover, the compounds of the present invention can be functionalized to conjugate imaging payload without decreasing binding strength.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: July 7, 2015
    Assignee: The Regents of the University of California
    Inventors: Kit S. Lam, Yan Wang, Wenwu Xiao
  • RGD-CONTAINING CYCLIC PEPTIDES
    Publication number: 20130172270
    Abstract: The present invention is drawn to cyclic RGD peptides linked via a disulfide bond, where the terminal cysteines are preferably in the D configuration. These peptides target ?v?3 integrin on tumor cells and neovasculatures and function as targeting agents for tumor diagnostic imaging and therapy. Compared with the commonly used RGD ligands, compounds of the present invention have improved targeting efficacy and lower nonspecific binding to normal organs. Moreover, the compounds of the present invention can be functionalized to conjugate imaging payload without decreasing binding strength.
    Type: Application
    Filed: December 16, 2010
    Publication date: July 4, 2013
    Applicant: The Regents of the University of California
    Inventors: Kit S. Lam, Yan Wang, Wenwu Xiao