Patents by Inventor Wenxin Xu

Wenxin Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising IL-15-based molecules and immune checkpoint inhibitor antibodies
    Patent number: 11992516
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: October 11, 2022
    Date of Patent: May 28, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20240131115
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: December 22, 2023
    Publication date: April 25, 2024
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Method for treating neoplasia with an anti-CD38 antibody and an IL-15:IL-15R complex
    Patent number: 11925676
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: February 27, 2023
    Date of Patent: March 12, 2024
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Method of treating cancer with composition comprising IL-15-based molecules and BCG
    Patent number: 11890323
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: February 6, 2024
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Long-term streamflow forecast method and system based on process-data synergic drive
    Patent number: 11886967
    Abstract: The present invention provides a long-term streamflow forecast method and system based on process-data synergic drive.
    Type: Grant
    Filed: July 17, 2023
    Date of Patent: January 30, 2024
    Assignee: WUHAN UNIVERSITY
    Inventors: Jie Chen, Wenxin Xu, Jiabo Yin, Lihua Xiong, Hua Chen
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230241175
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: February 28, 2023
    Publication date: August 3, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230241174
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: December 9, 2022
    Publication date: August 3, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230233649
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: February 27, 2023
    Publication date: July 27, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20230190877
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: October 11, 2022
    Publication date: June 22, 2023
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11679144
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: June 20, 2023
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11471511
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: October 18, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20220305087
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 29, 2022
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • Multimeric IL-15-based molecules
    Patent number: 11369679
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: June 28, 2022
    Assignee: Altor Bioscience, LLC
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • Multimeric IL-15-based molecules
    Patent number: 11318201
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: May 3, 2022
    Assignee: Altor Bioscience, LLC.
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert G. Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • MAXIMIZING T-CELL MEMORY AND COMPOSITIONS AND METHODS THEREFOR
    Publication number: 20220072045
    Abstract: Contemplated treatments and methods produce substantially increased quantities of memory T-cells and a persistent immune response by subcutaneous and/or subdermal co-administration of (1) a vector comprising a recombinant nucleic acid that encodes a cancer associated epitope, a cancer specific epitope, and/or a neoepitope, (2) an immune stimulating cytokine, and (3) a checkpoint inhibitor. Most typically, the co-administration is performed at substantially the same location, preferably within 1-21 days from each other, and the vector is an adenoviral expression vector, for example, included in a viral particle such as an AdV5 virus with a deletion of the E2b gene.
    Type: Application
    Filed: November 12, 2021
    Publication date: March 10, 2022
    Inventors: Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong, Hing Wong, Wenxin Xu
  • Maximizing T-cell memory and compositions and methods therefor
    Patent number: 11229668
    Abstract: Contemplated treatments and methods produce substantially increased quantities of memory T-cells and a persistent immune response by subcutaneous and/or subdermal co-administration of (1) a vector comprising a recombinant nucleic acid that encodes a cancer associated epitope, a cancer specific epitope, and/or a neoepitope, (2) an immune stimulating cytokine, and (3) a checkpoint inhibitor. Most typically, the co-administration is performed at substantially the same location, preferably within 1-21 days from each other, and the vector is an adenoviral expression vector, for example, included in a viral particle such as an AdV5 virus with a deletion of the E2b gene.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: January 25, 2022
    Assignees: NantCell, Inc., Nant Holdings IP, LLC
    Inventors: Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong, Hing Wong, Wenxin Xu
  • Multimeric IL-15-based molecules
    Patent number: 11197929
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: December 14, 2021
    Assignees: NantCell, Inc., Altor BioScience, LLC.
    Inventors: Hing C. Wong, Warren Marcus, Bai Liu, Wenxin Xu, Robert G. Newman, Karen Kage, Lijing You, Peter Rhode, Patrick Soon-Shiong
  • IL-15-based molecules and methods of use thereof
    Patent number: 11173191
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: November 16, 2021
    Assignee: Altor Bioscience, LLC.
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong
  • MULTIMERIC IL-15-BASED MOLECULES
    Publication number: 20210196821
    Abstract: The invention features multi-specific protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to a disease antigen, immune checkpoint or signaling molecule.
    Type: Application
    Filed: January 29, 2021
    Publication date: July 1, 2021
    Inventors: Hing C. WONG, Warren MARCUS, Bai LIU, Wenxin XU, Robert G NEWMAN, Karen KAGE, Lijing YOU, Peter RHODE, Patrick SOON-SHIONG
  • IL-15-BASED MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20210030844
    Abstract: The invention features combination therapies using an IL-15-based superagonist complex and an antibody to effectively treat subjects with cancer and infectious diseases.
    Type: Application
    Filed: July 9, 2020
    Publication date: February 4, 2021
    Inventors: Bai Liu, Peter Rhode, Wenxin Xu, Hing C. Wong