Patents by Inventor Wenyi Feng
Wenyi Feng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9780792Abstract: A random access memory circuit adapted for use in a field programmable gate array integrated circuit device is disclosed. The FPGA has a programmable array with logic modules and routing interconnects programmably coupleable to the logic modules and the RAM circuit. The RAM circuit has three ports: a first readable port, a second readable port, and a writeable port. The read ports may be programmably synchronous or asynchronous and have a programmably bypassable output pipeline register. The RAM circuit is especially well adapted for implementing register files. A novel interconnect method is also described.Type: GrantFiled: May 21, 2013Date of Patent: October 3, 2017Assignee: MICROSEMI SOC CORP.Inventors: Joel Landry, Jonathan Greene, William C. Plants, Wenyi Feng
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Publication number: 20170022559Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.Type: ApplicationFiled: July 12, 2016Publication date: January 26, 2017Applicant: Illumina, Inc.Inventors: Robert C. Kain, Xiaohai Liu, Wenyi Feng, Bernard Hirschbein, Helmy A. Eltoukhy, Xiaolin Wu, Geoffrey Paul Smith, Jonathan Mark Boutell, Thomas Joseph, Randall Smith, Min-Jui Richard Shen, Carolyn Tregidgo, Kay Klausing
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Patent number: 9453258Abstract: The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected.Type: GrantFiled: September 21, 2012Date of Patent: September 27, 2016Assignee: Illumina, inc.Inventors: Robert C. Kain, Xiaohai Liu, Wenyi Feng, Bernard Hirschbein, Helmy A. Eltoukhy, Xiaolin Wu, Geoffrey Paul Smith, Jonathan Mark Boutell, Thomas Joseph, Randall Smith, Min-Jui Richard Shen, Carolyn Tregidgo, Kay Klausing
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Patent number: 9365898Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.Type: GrantFiled: May 26, 2015Date of Patent: June 14, 2016Assignee: ILLUMINA, INC.Inventors: Wenyi Feng, Jason Bryant, Dale Buermann
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Publication number: 20160109693Abstract: Presented herein are systems and methods for performing sequencing, including fluorescence in situ sequencing. In one embodiment, a confocal time delay and integration (TDI) line scan imaging system may include various pinhole and/or slit aperture mechanisms in front of the image sensor. The system may also include structures with focusing strips on a substrate in contact with the tissue sample to be imaged. Alternatively, these strips may be cut into the tissue sample. The system may also include configurations and methods of placing a tissue sample inside a reaction chamber of a flow cell during the assembly of the flow cell and then performing chemistry operations on the tissue sample. The flow cells may use an open container for performing chemistry operations on the tissue sample.Type: ApplicationFiled: October 15, 2015Publication date: April 21, 2016Applicant: ILLUMINA, INC.Inventor: Wenyi Feng
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Patent number: 9201230Abstract: Systems and methods for facilitating focusing of an image scanner, such as a confocal microscope, are disclosed. Measurement of optical characteristics in certain areas of a test sample are compared to stored or baseline optical characteristic profiles to determine an appropriate correction to properly focus the scanner. In one aspect, the method includes obtaining a dynamic profile at a current detection region of a test sample and associating the dynamic profile to a profile selected from a set of stored baseline profiles. Each of the stored baseline profiles is associated with a correction.Type: GrantFiled: September 19, 2014Date of Patent: December 1, 2015Assignee: ILLUMINA, INC.Inventor: Wenyi Feng
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Patent number: 9147025Abstract: A method for programming a cluster-based field programmable gate array (FPGA) device includes providing a netlist and cluster size information, translating the netlist into a hypergraph, partitioning the hypergraph into multiple partitions and optimizing the Rent characteristic, translating the partitions into clusters, placing the clusters on the FPGA device, routing interconnects using a pre-fabricated routing resource on the FPGA device, generating a programming bitstream in response to the placing and routing, and providing the programming bitstream to the FPGA device to realize the user design.Type: GrantFiled: July 10, 2014Date of Patent: September 29, 2015Assignee: Microsemi SoC CorporationInventors: Wenyi Feng, Jonathan Greene, Kristofer Vorwerk, Val Pevzner, Arunangshu Kundu
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Patent number: 9139875Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.Type: GrantFiled: April 28, 2014Date of Patent: September 22, 2015Assignee: Illumina, Inc.Inventors: Alexander Triener, Erik Allegoren, Wenyi Feng, Dale Buermann, Erik Olson, James Osmus
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Publication number: 20150252416Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.Type: ApplicationFiled: May 26, 2015Publication date: September 10, 2015Inventors: Wenyi Feng, Jason Bryant, Dale Buermann
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Patent number: 9068220Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.Type: GrantFiled: March 28, 2014Date of Patent: June 30, 2015Assignee: ILLUMINA, INC.Inventors: Wenyi Feng, Jason Bryant, Dale Buermann
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Publication number: 20150079596Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.Type: ApplicationFiled: November 25, 2014Publication date: March 19, 2015Applicant: ILLUMINA, INC.Inventors: Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi
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Publication number: 20150069267Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: ApplicationFiled: September 18, 2014Publication date: March 12, 2015Applicant: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Publication number: 20150020038Abstract: A method for programming a cluster-based field programmable gate array (FPGA) device includes providing a netlist and cluster size information, translating the netlist into a hypergraph, partitioning the hypergraph into multiple partitions and optimizing the Rent characteristic, translating the partitions into clusters, placing the clusters on the FPGA device, routing interconnects using a pre-fabricated routing resource on the FPGA device, generating a programming bitstream in response to the placing and routing, and providing the programming bitstream to the FPGA device to realize the user design.Type: ApplicationFiled: July 10, 2014Publication date: January 15, 2015Inventors: Wenyi Feng, Jonathan Greene, Kristofer Vorwerk, Val Pevzner, Arunangshu Kundu
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Publication number: 20150009491Abstract: Systems and methods for facilitating focusing of an image scanner, such as a confocal microscope, are disclosed. Measurement of optical characteristics in certain areas of a test sample are compared to stored or baseline optical characteristic profiles to determine an appropriate correction to properly focus the scanner. In one aspect, the method includes obtaining a dynamic profile at a current detection region of a test sample and associating the dynamic profile to a profile selected from a set of stored baseline profiles. Each of the stored baseline profiles is associated with a correction.Type: ApplicationFiled: September 19, 2014Publication date: January 8, 2015Inventor: Wenyi Feng
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Patent number: 8906320Abstract: A biosensor is provided including a detection device and a flow cell mounted to the detection device. The detection device has a detector surface with a plurality of reaction sites. The detection device also includes a filter layer that is configured to at least one of (a) filter unwanted excitation light signals; (b) direct emission signals from a designated reaction site toward one or more associated light detectors that are configured to detect the emission signals from the designated reaction site; or (c) block or prevent detection of crosstalk emission signals from adjacent reaction sites.Type: GrantFiled: March 15, 2013Date of Patent: December 9, 2014Assignee: Illumina, Inc.Inventors: Helmy A. Eltoukhy, Robert C. Kain, Wenyi Feng, Mark Pratt, Bernard Hirschbein, Poorya Sabounchi
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Patent number: 8884211Abstract: The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.Type: GrantFiled: March 12, 2012Date of Patent: November 11, 2014Assignee: Illumina, Inc.Inventors: Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain
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Patent number: 8867029Abstract: Systems and methods for facilitating focusing of an image scanner, such as a confocal microscope, are disclosed. Measurement of optical characteristics in certain areas of a test sample are compared to stored or baseline optical characteristic profiles to determine an appropriate correction to properly focus the scanner. In one aspect, the method includes obtaining a dynamic profile at a current detection region of a test sample and associating the dynamic profile to a profile selected from a set of stored baseline profiles. Each of the stored baseline profiles is associated with a correction.Type: GrantFiled: June 24, 2010Date of Patent: October 21, 2014Assignee: Illumina, Inc.Inventor: Wenyi Feng
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Publication number: 20140228225Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.Type: ApplicationFiled: April 28, 2014Publication date: August 14, 2014Applicant: ILLUMINA, INC.Inventors: ALEXANDER TRIENER, ERIK ALLEGOREN, WENYI FENG, DALE BUERMANN, ERIK OLSON, JAMES OSMUS
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Publication number: 20140213486Abstract: A system and method for imaging biological samples on multiple surfaces of a support structure are disclosed. The support structure may be a flow cell through which a reagent fluid is allowed to flow and interact with the biological samples. Excitation radiation from at least one radiation source may be used to excite the biological samples on multiple surfaces. In this manner, fluorescent emission radiation may be generated from the biological samples and subsequently captured and detected by detection optics and at least one detector. The detected fluorescent emission radiation may then be used to generate image data. This imaging of multiple surfaces may be accomplished either sequentially or simultaneously. In addition, the techniques of the present invention may be used with any type of imaging system. For instance, both epifluorescent and total internal reflection methods may benefit from the techniques of the present invention.Type: ApplicationFiled: March 28, 2014Publication date: July 31, 2014Applicant: Illumina, Inc.Inventors: Wenyi Feng, Jason Bryant, Dale Buermann
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Patent number: 8748789Abstract: An optical system configured to detect optical signals during imaging sessions. The optical system includes an objective lens that has a collecting end that is positioned proximate to a sample and configured to receive optical signals therefrom. The optical system also includes a removable path compensator that is configured to be located at an imaging position between the collecting end of the objective lens and the sample. The path compensator adjusts an optical path of the light emissions when in the imaging position. Also, the optical system includes a transfer device that is configured to move the path compensator. The transfer device locates the path compensator at the imaging position for a first imaging session and removes the path compensator from the imaging position for a second imaging session.Type: GrantFiled: May 30, 2013Date of Patent: June 10, 2014Assignee: Illumina, Inc.Inventors: Alexander Triener, Erik Allegoren, Wenyi Feng, Dale Buermann, Erik Olson, James Osmus