Patents by Inventor Werner Heilmann

Werner Heilmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide
    Patent number: 10822305
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: November 3, 2020
    Assignee: BAYER HEALTHCARE LLC
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • Process for the Preparation of 4-(4-amino-3-fluorophenoxy)-N-methylpyyridine-2-carboxamide
    Publication number: 20190144391
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: January 9, 2019
    Publication date: May 16, 2019
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael LÖGERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • Method of Purifying and using 4-chloro-n-methy1-2-pyridinecarboxamide
    Publication number: 20170334857
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: August 3, 2017
    Publication date: November 23, 2017
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael LOGERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE
    Publication number: 20170057918
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: September 8, 2016
    Publication date: March 2, 2017
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael LÖGERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorphenoxy--ethylpyridie-carboxamide, its salts and monohydrate
    Patent number: 9458107
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Grant
    Filed: April 15, 2014
    Date of Patent: October 4, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-ETHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE
    Publication number: 20140221661
    Abstract: The present invention relates to a process for preparing 4-(4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy)-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 7, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen STIEHL, Werner HEILMANN, Michael L.GERS, Joachim REHSE, Michael GOTTFRIED, Saskia WICHMANN
  • Process for the preparation of 4-{4[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}--methylpyridine-2-carboxamide, its salts and monohydrate
    Patent number: 8748622
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Grant
    Filed: April 8, 2011
    Date of Patent: June 10, 2014
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • PROCESS FOR THE PREPARATION OF 4-CARBONYL)AMINO]-3-FLUOROPHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, ITS SALTS AND MONOHYDRATE
    Publication number: 20130116442
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoromethyl)-phenyl]amino}carbonyl)amino]-3-fluorophenoxy}-N-methylpyridine-2-carboxamide, its salts and monohydrate.
    Type: Application
    Filed: April 8, 2011
    Publication date: May 9, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Juergen Stiehl, Werner Heilmann, Michael Lögers, Joachim Rehse, Michael Gottfried, Saskia Wichmann
  • Process for the preparation of 4-{4-[({[4 chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide
    Patent number: 8124782
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoro-methyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: February 28, 2012
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Michael Lögers, Reinhold Gehring, Oliver Kuhn, Mike Matthäus, Klaus Mohrs, Matthias Müller-Gliemann, Jürgen Stiehl, Mathias Berwe, Jana Lenz, Werner Heilmann
  • Process for the Preparation of 4-Carbonyl)Amino]Phenoxy}-N-Methylpyridine-2-Carboxamide
    Publication number: 20080262236
    Abstract: The present invention relates to a process for preparing 4-{4-[({[4-chloro-3-(trifluoro-methyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide and its tosylate salt.
    Type: Application
    Filed: September 20, 2005
    Publication date: October 23, 2008
    Applicant: Bayer HealthCare AG
    Inventors: Michael Logers, Reinhold Gehring, Oliver Kuhn, Mike Matthaus, Klaus Mohrs, Matthias Muller-Gliemann, Jurgen Stiehl, Mathias Berwe, Jana Lenz, Werner Heilmann
  • Method for producing 8-methoxy-quinolinecarboxylic acids
    Patent number: 7115744
    Abstract: The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: October 3, 2006
    Assignee: Bayer Healthcare Aktiengesellschaft
    Inventors: Reinhold Gehring, Klaus Mohrs, Werner Heilmann, Herbert Diehl
  • Process for the preparation of sulphonamide-substituted imidazotriazinones
    Patent number: 6998483
    Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
    Type: Grant
    Filed: May 5, 2005
    Date of Patent: February 14, 2006
    Assignee: Bayer HealthCare Aktiengesellschaft
    Inventors: Marc Nowakowski, Reinhold Gehring, Werner Heilmann, Karl-Heinz Wahl
  • Method for producing 8-methoxy-quinoline carboxylic acids
    Publication number: 20050209276
    Abstract: The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action.
    Type: Application
    Filed: May 11, 2005
    Publication date: September 22, 2005
    Applicant: Bayer Healthcare Aktiengesellschaft
    Inventors: Reinhold Gehring, Klaus Mohrs, Werner Heilmann, Herbert Deihl
  • Process for the preparation of sulphonamide-substituted imidazotriazinones
    Publication number: 20050203298
    Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
    Type: Application
    Filed: May 5, 2005
    Publication date: September 15, 2005
    Applicant: Bayer HealthCare Aktiengesellschaft
    Inventors: Marc Nowakowski, Reinhold Gehring, Werner Heilmann, Karl-Heinz Wahl
  • Method for producing 8-methoxy-quinolinecarboxylic acids
    Patent number: 6897315
    Abstract: The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: May 24, 2005
    Assignee: Bayer HealthCare Aktiengesellschaft
    Inventors: Reinhold Gehring, Klaus Mohrs, Werner Heilmann, Herbert Diehl
  • Process for the preparation of sulphonamide-substituted imidazotriazinones
    Publication number: 20050014756
    Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
    Type: Application
    Filed: July 2, 2004
    Publication date: January 20, 2005
    Applicant: Bayer Aktiengesellschaft
    Inventors: Marc Nowakowski, Reinhold Gehring, Werner Heilmann, Karl-Heinz Wahl
  • Process for the preparation of sulphonamide-substituted imidazotriazinones
    Patent number: 6777551
    Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: August 17, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Marc Nowakowski, Reinhold Gehring, Werner Heilmann, Karl-Heinz Wahl
  • Method for producing 8-methoxy-quinoline carboxylic acids
    Publication number: 20030208069
    Abstract: The present invention relates to a novel process for preparing 8-methoxy-3-quinolonecarboxylic acids which are antibiotics having potent antibacterial action.
    Type: Application
    Filed: April 3, 2003
    Publication date: November 6, 2003
    Applicant: Bayer Aktiengesellschaft
    Inventors: Reinhold Gehring, Klaus Mohrs, Werner Heilmann, Herbert Deihl
  • Process for the preparation of sulphonamide-substituted imidazotriazinones
    Publication number: 20020137930
    Abstract: The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) 1
    Type: Application
    Filed: December 17, 2001
    Publication date: September 26, 2002
    Inventors: Marc Nowakowski, Reinhold Gehring, Werner Heilmann, Karl-Heinz Wahl
  • Process for the production of cycloalkanecarboxylic acids
    Patent number: 4816602
    Abstract: Process for the production of cycloalkanecarboxylic acids of general Formula I ##STR1## wherein n means the number 1 or 2,R.sub.1 and R.sub.3 are alkyl groups of 1-4 carbon atoms, andR.sub.2 and R.sub.4 symbolize hydrogen atoms or alkyl groups of 1-4 carbon atoms,characterized by reacting a compound of general Formula IIX--CR.sub.1 R.sub.2 --(CH.sub.2).sub.n --CH.sub.2 --CR.sub.3 R.sub.4 --X'(II),whereinn, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the meanings given above andX and X' mean a hydroxy group, a chlorine atom, a bromine atom, an alkylsulfonyloxy residue, or an arylsulfonyloxy residue,with 1,1-dichloroethylene;splitting off hydrogen chloride from the thus-obtained compounds of general Formula IIIX--CR.sub.1 R.sub.2 --(CH.sub.2).sub.n --CH.sub.2 --CR.sub.3 R.sub.4 --CH.sub.2 --CCl.sub.2 X (III),wherein n, X, X', R.sub.1, R.sub.2, R.sub.3 and R.sub.4 have the meanings given above; and cyclizing and hydrolyzing, by means of acids, the thus-prepared compounds of general Formula IVX--CR.sub.1 R.sub.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: March 28, 1989
    Assignee: Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Herbert Mayr, Werner Heilmann, Helmut Vorbrueggen