Patents by Inventor Wesley A. Smith

Wesley A. Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240256032
    Abstract: In some embodiments, an electronic device selectively de-emphasizes a three-dimensional environment in which content is presented. In some embodiments, an electronic device modifies the boundaries of content in a user interface. In some embodiments, an electronic device shares content with users in a three-dimensional environment.
    Type: Application
    Filed: January 26, 2024
    Publication date: August 1, 2024
    Inventors: Wesley M. HOLDER, Christopher D. MCKENZIE, Israel PASTRANA VICENTE, Connor A. SMITH
  • Publication number: 20240218011
    Abstract: The present disclosure describes glucocorticoid agonist compounds, their conjugates with binding proteins, pharmaceutical compositions thereof, as well as methods and uses for treating diseases or conditions, such as autoimmune or inflammatory conditions.
    Type: Application
    Filed: July 20, 2023
    Publication date: July 4, 2024
    Inventors: Sean Wesley Smith, Scott Allan Mitchell, Jack Chang Hung Lee
  • Publication number: 20240189899
    Abstract: Provided herein are various enhancements for additive manufacturing using titanium and titanium alloy materials. In one example, a method includes inoculating a titanium material with ceramic particles that produce nucleation sites within the titanium material during successive melt and solidification steps of an additive manufacturing process. The nucleation sites promote grain nucleation during solidification of molten titanium material into solid titanium material during the additive manufacturing process.
    Type: Application
    Filed: December 5, 2022
    Publication date: June 13, 2024
    Applicant: Lockheed Martin Corporation
    Inventors: Zachary Loftus, Scott William Cochran, Michael A. Reale, Scott Wesley Smith
  • Patent number: 11993831
    Abstract: Printable high-strength alloys, including aluminum alloys can be produced in an additive manufacturing process. Such alloys can include aluminum-silver (“Al—Ag”) alloys that are produced by a laser melting process using a powder bed fusion. The results of the process and the characteristics of the produced alloy can be determined by controlling at least an energy beam power, an energy beam speed, and/or an energy beam size. The operational parameters can be controlled with high precision to produce a printable, high-strength aluminum alloy.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: May 28, 2024
    Assignee: Lockheed Martin Corporation
    Inventors: Scott Wesley Smith, Servando D. Cuellar, Michael A. Reale, Ivan Audon Lucatero Sanchez
  • Publication number: 20240067640
    Abstract: Compounds useful as linker-payload compounds are disclosed. The compounds have the following Structure (I): as a stereoisomer, enantiomer or tautomer thereof or a mixture thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein X1, X2, X3, X4, X5, R4a, and R4b are as defined herein. Additional compounds, conjugates, methods of preparation, pharmaceutical compositions, and methods of treatment related to conjugates of compounds of Structure (I) and a targeting moiety, or binding fragment thereof, are also provided.
    Type: Application
    Filed: March 10, 2023
    Publication date: February 29, 2024
    Inventors: Sean Wesley Smith, Scott Allan Mitchell, Jack Chang Hung Lee
  • Patent number: 11669301
    Abstract: The present disclosure relates to fuse multiple database tables together. The fields of the database tables may be normalized using semantic fields. Under a first approach, database tables are deduplicated by consolidating redundant records. This may be done by performing pairwise comparisons to identify related pairs of records and then clustering the related pairs of records. Then, the deduplicated database tables are merged by performing another pairwise comparison. Under a second approach, the database tables may be concatenated. Thereafter, records are subject to pairwise comparisons and then clustered to create a merged database table.
    Type: Grant
    Filed: November 25, 2020
    Date of Patent: June 6, 2023
    Assignee: AMPERITY, INC.
    Inventors: Stephen Meyles, Yan Yan, Carlos Sakoda, Ian Wesley-Smith, Dan Suciu
  • Publication number: 20220362396
    Abstract: Amino-pyrazinecarboxamide compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGF?R2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: November 24, 2020
    Publication date: November 17, 2022
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
  • Publication number: 20220350093
    Abstract: Provided are optical fiber alignment assemblies, comprising: a plurality of fiber channel members being arranged along a first vertical axis, each fiber channel member comprising a fiber channel configured to accommodate an optical fiber disposed therein, the plurality of fiber channels being parallel to one another, fiber channels adjacent to one another defining a spacing therebetween, the spacing being measured along the first vertical axis; a plurality of resilient members, a resilient member being disposed between adjacent fiber channel members; and an adjustment element, the adjustment element being configured to effect a force oriented along the first vertical axis, and the adjustment member being configured such that actuation of the adjustment member changes a compression of the plurality of resilient members so as to effect an essentially linear variation in the spacing between adjacent fiber channels. Also provided are related methods.
    Type: Application
    Filed: April 26, 2022
    Publication date: November 3, 2022
    Inventors: Derek Robinson, Wesley Smith, Keith Kearsley
  • Publication number: 20220323596
    Abstract: Imidazoquinoline compounds of formula (IA), conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed imidazoquinoline compounds are useful, among other things, in the treating of cancer and modulating TLR7. Additionally, imidazoquinoline compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: September 12, 2019
    Publication date: October 13, 2022
    Inventors: Sean Wesley SMITH, Craig Alan COBURN
  • Publication number: 20220169660
    Abstract: Cyclic amino-pyrazinecarboxamide compounds, salts, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of disease, for example cancer and/or fibrotic diseases, and modulating TGF?R2.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 2, 2022
    Inventors: Sean Wesley SMITH, Craig Alan COBURN
  • Publication number: 20220127629
    Abstract: The invention is directed to recombinant bacteria, a recombinant plasmid, a pharmaceutical composition and a kit as well as the use of a reconstitution medium comprising chloride ions to reconstitute the recombinant bacteria.
    Type: Application
    Filed: March 4, 2019
    Publication date: April 28, 2022
    Inventors: Thomas Wirth, Juha Yrjänheikki, Haritha Samaranayake, Hanna-Riikka Kärkkäinen, Jere Kurkipuro, Igor Mierau, Wesley Smith
  • Publication number: 20220068152
    Abstract: A system, apparatus, and method to provide a systematic assessment learning approach that is utilized through a computing device to determine its users sport IQ score for one or more sports is disclosed. The system includes a multi-dimensional, systematic learning assessment processor to correlate answered questions and compute the sport IQ-score. In some cases, the questions in the database may include videos of sport content and other associated sport content. The system presents a quantifiable metric of a user's performance potential in a sport and provides a learning program for developing the user's skills across multiple dimensions.
    Type: Application
    Filed: August 25, 2021
    Publication date: March 3, 2022
    Inventors: Clarence R. Johnson, Robert Wesley Smith, Regis Bolden, II, Sandeep Mehta, Zuwana Johnson, Javarro Russell, David Michael Schor
  • Publication number: 20220048895
    Abstract: Benzazepine compounds and salts thereof, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed benzazepine compounds and salts thereof are useful, among other things, in treating of cancer and activating an immune response. Additionally, benzazepine compounds or salts thereof attached to an antibody construct to form an antibody conjugate are described herein.
    Type: Application
    Filed: September 12, 2019
    Publication date: February 17, 2022
    Inventors: Craig Alan COBURN, Sean Wesley SMITH
  • Publication number: 20220051157
    Abstract: Systems and methods are described which manage, in real time, and without impeding the natural flow of vehicles, a preferred flow of traffic within a geographic location based on prior modeling and simulation.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 17, 2022
    Inventors: Wesley Smith, Levi Crain, Max Johansen, Brian Ng
  • Patent number: 11130186
    Abstract: A replaceable tooth for a circular saw with a base and angled cutting surfaces defining nadirs of intersection between adjacent cutting surfaces. Inserts are provided to cover facets of the angled cutting surfaces of the replaceable tooth. Plugs of a hardened material are provided immediately below each nadir of intersection to prevent erosion of the tooth base below the intersections of the inserts.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: September 28, 2021
    Assignee: QUALITY CHAIN CANADA LTD.
    Inventor: Wesley Smith
  • Publication number: 20210205907
    Abstract: A replaceable tooth for a circular saw having a base and angled cutting surfaces defining nadirs of intersection between them and inserts covering the facets of the cutting surfaces. Plugs of a hardened material are provided immediately below each nadir of intersection to prevent erosion of the base of the tooth below the intersections of the inserts.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 8, 2021
    Inventor: Wesley Smith
  • Publication number: 20210154317
    Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.
    Type: Application
    Filed: June 24, 2020
    Publication date: May 27, 2021
    Inventors: Peter Armstrong Thompson, Valerie Odegard, Robert Finley Dubose, Sean Wesley Smith, Craig Alan Coburn
  • Publication number: 20210154188
    Abstract: Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALKS. Compounds incorporated into a conjugate with an antibody construct are also described herein.
    Type: Application
    Filed: April 2, 2019
    Publication date: May 27, 2021
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Robert Finley Dubose
  • Publication number: 20210139477
    Abstract: ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.
    Type: Application
    Filed: July 16, 2020
    Publication date: May 13, 2021
    Inventors: Sean Wesley Smith, Craig Alan Coburn, Peter Robert Baum, Robert Finley Dubose
  • Publication number: 20210077632
    Abstract: Aqueous formulations comprising conjugates that comprise a compound comprising benzazepine or a benzazepine-like structure conjugated to a polypeptide are provided, as well as methods of treatment using the aqueous formulations. Lyophilized compositions comprising the conjugates that comprise a compound comprising benzazepine or a benzazepine-like structure conjugated to a polypeptide are also provided.
    Type: Application
    Filed: August 14, 2020
    Publication date: March 18, 2021
    Applicant: Silverback Therapeutics, Inc.
    Inventors: Sean Wesley Smith, Sateesh Natarajan