Abstract: A coated part, such as a ceramic coated part, having a slot formed in a coating formed on a curvilinear portion of the part and a method of forming the slot. The method includes performing a plurality of laser ablation passes. Each laser ablation pass includes focusing a laser beam to a focus depth, irradiating the coating of the curvilinear portion with the laser beam focused at the focus depth to remove coating material of the coating by laser ablation, and scanning the laser beam in a scanning direction while irradiating the coating of the curvilinear portion with the laser beam. The scanning direction is a direction transverse to a thickness direction of the coating. The focus depth of each subsequent pass of the plurality of laser ablation passes is deeper in a thickness direction of the coating than the pass preceding the subsequent pass.

Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Abstract: A disposable cell enrichment kit includes a crossflow filtration device configured to be disposed along a main loop pathway and to receive a process volume containing a biological sample and utilize crossflow filtration, via a micro-porous membrane, to retain a specific cell population in a retentate from the process volume and to remove a permeate including certain biological components from the process volume. The crossflow filtration device includes a laminated filtration unit that includes the micro-porous membrane, a first mating portion, a second mating portion, and a membrane support. The membrane support includes a first plurality of structural features that define a first plurality of openings, wherein the first plurality of structural features are coupled to the micro-porous membrane and provide support to the micro-porous membrane, and the first plurality of openings allow the permeate to flow through them after crossing the micro-porous membrane.

Abstract: A gripping element may be commanded to move to pre-determined robot-frame locations, and markings may be punched into a calibration sample capture substrate at each location. A calibration image may be obtained, and fiducial markings on the gripping element may be detected. A set of calibration regions of interest may be predicted, and the previously punched markings may be detected. A sampling system may then create a mapping transfer function between detected image locations and real-world locations resulting from the commanded locations of the gripping element when the markings were punched. An indication may subsequently be received that a biological sample capture substrate is ready to be processed. An image of the sample capture substrate may be obtained, and the fiducial markings may be detected. Based on those image locations and the mapping transfer function, biological sample portions may be automatically taken from the sample capture substrate.

Abstract: A gripping element may be commanded to move to pre-determined robot-frame locations, and markings may be punched into a calibration sample capture substrate at each location. A calibration image may be obtained, and fiducial markings on the gripping element may be detected. A set of calibration regions of interest may be predicted, and the previously punched markings may be detected. A sampling system may then create a mapping transfer function between detected image locations and real-world locations resulting from the commanded locations of the gripping element when the markings were punched. An indication may subsequently be received that a biological sample capture substrate is ready to be processed. An image of the sample capture substrate may be obtained, and the fiducial markings may be detected. Based on those image locations and the mapping transfer function, biological sample portions may be automatically taken from the sample capture substrate.

Abstract: A system and method of imaging an imaged subject is provided. The system comprises a controller, and an imaging system including an imaging probe in communication with the controller. The imaging probe includes a transducer array operable to move through a range of motion along a first imaging path at a first speed to acquire a first set of image data. The transducer array can be operable to move through the range of motion along the first imaging path at a second speed greater than the first speed so as to acquire an update image data at a rate faster than acquisition of the first set of image data.

Abstract: A system and method of imaging an imaged subject is provided. The system comprises a controller, and an imaging system including an imaging probe in communication with the controller. The imaging probe includes a transducer array operable to move through a range of motion along a first imaging path at a first speed to acquire a first set of image data. The transducer array can be operable to move through the range of motion along the first imaging path at a second speed greater than the first speed so as to acquire an update image data at a rate faster than acquisition of the first set of image data.

Abstract: A mobile radiographic device for use in inspecting pipelines and the like, comprising an articulating aerial boom coupled to a mobile carriage vehicle. A pivot mount is rotatably coupled to the distal end of the aerial boom. A platform having a sliding rail is operatively coupled to the pivot mount. A mounting fixture is rotatably mounted to a cradle, which in turn is coupled to the sliding rail of the platform. A radiation source and a radiation detector are mounted on diametrically opposing sides of the fixture in order to illuminate the outer surface of a pipeline or other object with radiation. A first positioning means is provided for coarsely positioning the scanning apparatus relative to the pipeline. A second positioning means is provided for finely positioning the scanning apparatus relative to the pipeline. The second positioning means is operable from a remote location when the radiation source is illuminating the pipeline with radiation.