Abstract: The metabolization of certain phenols, monophenols or benzenediols into reactive quinone compounds, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. The compounds function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens to treat malignancies.

Abstract: The metabolization of certain phenols, monophenols or benzenediols into reactive quinone compounds, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. The compounds function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens to treat malignancies.

Abstract: The invention is based on the observation that certain phenols, monophenols or benzenediols, can be metabolized into reactive quinones, in particular ortho-quinones and related reactive intermediates, which is brought about by oxidation of monophenols and benzenediols by proteins exhibiting tyrosinase activity, such as human tyrosinase and the related proteins TRP1 and TRP2. Although the substances and the produced reactive intermediates are toxic and can induce cell death, it is more relevant according to this invention that they function as haptens that become covalently bound to the tyrosinase enzymes, in particular to histidine moieties, in or near the catalytic site of proteins exhibiting tyrosinase activity, such as tyrosinase, TRP1 and TRP2. An immune response is then to be mounted against these haptenized auto-antigens, in order to treat melanocytic malignancies, in particular melanomas.

Abstract: A meat product containing in vitro produced animal cells in a three dimensional form and a method for producing the meat product.

Abstract: A method and composition for treating biopsy wounds in human patients is provided. The process involves filling the wound with a disc of collagenous material coated with elastine, with the disc of material being of a size to substantially fill the biopsy wound. The collagenous material is preferably derived from the skin of hoofed animals such as calves, sheep and pigs. The disc is combined with a microporous top layer, preferably polyether urethane.This combination is easy to apply and leads to hemostasis, improved wound healing and less wound contraction and scarring.

Abstract: The invention relates to the use of polysaccharide containing materials in particular vegetable fibres or products derived therefrom originating from Plantago ovata, in particular from the seed husk thereof for the production of preparations for wound treatment. These and similar vegetable fibres or products derived therefrom may be combined with another active substance chosen from the group comprising proteolytic enzymes, antiseptic agents, growth stimulators and electrolytes.