Abstract: A patient computing device and a set of behavioral and/or physiological parameter monitoring elements are configured for automatically: monitoring patient behavioral and/or physiological parameters over time; processing patient behavioral and/or physiological parameter data relative to a patient behavioral and/or mental health baseline state; determining whether a patient anomaly condition exists; and in response to the existence of a patient anomaly condition, automatically: determining a severity level corresponding to the anomaly condition; initiating execution of a behavioral therapy automaton; initiating execution of an automated patient dialog process that operates only on the patient computing device, without transfer of patient data and/or patient-identifying data external to the patient computing device; and/or selectively initiating data communication with an external electronic device or computing device or system corresponding to a care provider or care provider team associated with the patient in

Abstract: Methods and devices are provided for delivering a drug to or withdrawing a fluid from a biological tissue, such the skin, sclera, cornea, and conjunctiva. One method includes the steps of inserting at least one microneedle into the biological tissue; partially retracting the at least one microneedle from the tissue; and then delivering at least one drug formulation into the biological tissue via the partially retracted at least one microneedle. The microneedle deforms and penetrates the biological tissue during the insertion step, and the retraction step at least partially relaxes the tissue deformation while maintaining at least part of the tissue penetration, facilitating drug delivery or fluid withdrawal.