Abstract: An mRNA vaccine includes one or more polynucleotides and a pharmaceutically acceptable vector. Each polynucleotide includes a coding region. The coding region includes a gene of interest and a ligand sequence which encodes a CD40 ligand.

Abstract: A holding apparatus includes a top holder having a coupler and a top casing capable of adjusting the distance and tilt therebetween using three points adjustment. When a microfluidic device along with a cover are disposed on a bottom holder of the holding apparatus and the top holder is pivoted with respect to the bottom holder to a closed position, the contact surface of soft plugs on the coupler and the cover can be made parallel by a certain distance with a first surface of the microfluidic device, and the distance between the coupler and the top casing determines the pressure exerted through elastic components onto the microfluidic device, so that external pipes can be seamlessly attached to the microfluidic device and also ensuring no deformation due to external forces should happen on microfluidic device.

Abstract: A holding apparatus includes a top holder having a coupler and a top casing capable of adjusting the distance and tilt therebetween using three points adjustment. When a microfluidic device along with a cover are disposed on a bottom holder of the holding apparatus and the top holder is pivoted with respect to the bottom holder to a closed position, the contact surface of soft plugs on the coupler and the cover can be made parallel by a certain distance with a first surface of the microfluidic device, and the distance between the coupler and the top casing determines the pressure exerted through elastic components onto the microfluidic device, so that external pipes can be seamlessly attached to the microfluidic device and also ensuring no deformation due to external forces should happen on microfluidic device.

Abstract: The present invention provides a particle transporting system including a holder, a vibrator and a tube. The vibrator connects the holder to provide vibration to the holder. The tube spirally surrounds the holder. A method of operating a particle transporting system is provided. The method includes the following steps: (a) providing a particle transporting system as shown above; (b) injecting a sample fluid with plural particles into the tube; and (c) transporting the sample fluid with the particles to a target apparatus with vibration provided by the vibrator.

Abstract: The present invention relates to a method of identifying an expression level of cystathionine gamma lyase (CTH) in a sample from a subject. The present invention further discloses a method of diagnosing a subject with cancer having risk of resistance to a platinum-based drug. The present invention also discloses a method for improving efficacy of a platinum-based drug in a subject suffering a cancer.

Abstract: A relatively specific trophoblastic-associated biomarker, HSD3B1, is disclosed. A method for screening gestational trophoblastic disease using HSD3B1 is also disclosed.

Abstract: A relatively specific trophoblastic-associated biomarker, HSD3B1, is disclosed. A method for screening gestational trophoblastic disease using HSD3B1 is also disclosed.