Abstract: A conjugate for targeting antigen-presenting cells, including at least one antigenic moiety conjugated to a targeting moiety that is capable of binding to a cell surface structure of an antigen-presenting cell, wherein the conjugate is capable of being internalized and processed by the antigen-presenting cells such as to cause processed antigenic moiety fragments thereof to be presented via MHC class I and MHC class II molecules of the antigen-presenting cell, to a nucleic acid sequence including, a nucleic acid sequence encoding the antigenic moiety and a nucleic acid sequence encoding the targeting moiety, to a host cell to a method for producing a conjugate, and for generating an antigen-presenting cell capable of eliciting an immune response to such antigen-presenting cell, to a pharmaceutical composition comprising a conjugate or an antigen-presenting cell and their use for vaccination, and as a medicament.