Patents by Inventor Wilhelmina Maria Hardeman
Wilhelmina Maria Hardeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10307759Abstract: The invention relates to a method and a biosensor system (300) for the detection of target components (TC) in a biological sample. In a preferred embodiment, magnetic purification particles (PP) are added to the sample that can bind interfering components (IC) (if present) which interfere with the detection process. The purification particles (PP) with bound interfering components (IC) may be removed from the sample and transferred through a magneto-capillary valve (MCV1) into a waste chamber (320).Type: GrantFiled: June 24, 2015Date of Patent: June 4, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Albert Hendrik Jan Immink, Jeroen Hans Nieuwenhuis, Gwenola Sabatte, Wilhelmina Maria Hardeman
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Patent number: 9921353Abstract: A light emitting device (1) comprising a light source (2) adapted for, in operation, emitting light (13) with a first spectral distribution, a first light guide (3) comprising a first light input surface (31) and a first light exit surface (32) arranged opposite to one another, and further comprising an end surface (35) extending perpendicular with respect to the first light input surface (31), and a second light guide (4) comprising a second light input surface (41) and a second light exit surface (42) extending perpendicular with respect to one another.Type: GrantFiled: June 5, 2014Date of Patent: March 20, 2018Assignee: PHILIPS LIGHTING HOLDING B.V.Inventors: Rifat Ata Mustafa Hikmet, Dirk Kornelis Gerhardus De Boer, Ties Van Bommel, Wilhelmina Maria Hardeman, Marcus Antonius Verschuuren
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Patent number: 9778254Abstract: A system and method wherein components of a reagent such as labeled antibodies are separated from a biologically active sensor surface by depositing the reagent on a carrier surface distinct from a sensor surface in a detection region. The present device provides a short, well-defined and controlled, pre-incubation time between the particles of interest in the sample fluid and the reagent, thereby increasing the reproducibility by providing all components in one detection region such as a detection chamber.Type: GrantFiled: July 18, 2008Date of Patent: October 3, 2017Assignees: KONINKLIJKE PHILIPS N.V., CONCATENO UK LIMITEDInventors: Femke Karina De Theije, Thea Van Der Wijk, Albert Hendrik Jan Immink, Eduard Gerard Marie Pelssers, Wilhelmina Maria Hardeman, Sandra Marlin, Gordon Thomas Jowett
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Publication number: 20170113223Abstract: The invention relates to a method and a biosensor system (300) for the detection of target components (TC) in a biological sample. In a preferred embodiment, magnetic purification particles (PP) are added to the sample that can bind interfering components (IC) (if present) which interfere with the detection process. The purification particles (PP) with bound interfering components (IC) may be removed from the sample and transferred through a magneto-capillary valve (MCV1) into a waste chamber (320).Type: ApplicationFiled: June 24, 2015Publication date: April 27, 2017Inventors: ALBERT HENDRIK JAN IMMINK, JEROEN HANS NIEUWENHUIS, GWENOLA SABATTE, WILHELMINA MARIA HARDEMAN
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Patent number: 9612239Abstract: The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.Type: GrantFiled: February 27, 2012Date of Patent: April 4, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Joannes Baptist Adrianus Dionisius Van Zon, Toon Hendrik Evers, Ron Martinus Laurentius Van Lieshout, Wilhelmina Maria Hardeman, Derk Jan Wilfred Klunder
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Patent number: 9612236Abstract: The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.Type: GrantFiled: June 14, 2011Date of Patent: April 4, 2017Assignee: Koninklijke Philips N.V.Inventors: Gwenola Sabatte, Menno Willem Jose Prins, Toon Hendrik Evers, Wilhelmina Maria Hardeman, Joukje Garrelina Orsel
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Publication number: 20160131813Abstract: A light emitting device (1) comprising a light source (2) adapted for, in operation, emitting light (13) with a first spectral distribution, a first light guide (3) comprising a first light input surface (31) and a first light exit surface (32) arranged opposite to one another, and further comprising an end surface (35) extending perpendicular with respect to the first light input surface (31), and a second light guide (4) comprising a second light input surface (41) and a second light exit surface (42) extending perpendicular with respect to one another.Type: ApplicationFiled: June 5, 2014Publication date: May 12, 2016Inventors: Rifat Ata Mustafa HIKMET, Dirk Kornelis Gerhardus DE BOER, Ties VAN BOMMEL, Wilhelmina Maria HARDEMAN, Marcus Antonius VERSCHUUREN
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Publication number: 20140134602Abstract: The invention relates to a substance determining apparatus (19) for determining a substance within a fluid. A location event determination unit (34) determines location events indicating that a particle, which may have attached the substance, is located in a sensing region and a property of the location events from the sensing signal generated by sensing the sensing region. A location events selection unit (70) selects a part of the location events having a property in a predefined property range, and a substance determination unit (40) determines the substance within the fluid (3) based on the selected part of the location events. This allows tuning the determination of the substance within the fluid to a desired property range, which can relate to a desired kind of bound particles, thereby reducing the influence of unwanted effects on the determination of the substance and, thus, improving the determination accuracy.Type: ApplicationFiled: February 27, 2012Publication date: May 15, 2014Applicant: KONINKLIJKE PHILIPS N.V.Inventors: Joannes Baptist Andrianus Dionisius Van Zon, Toon Hendrik Evers, Ron Martinus Laurentius Van Lieshout, Wilhelmina Maria Hardeman, Derk Jan Wilfred Klunder
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Publication number: 20130109030Abstract: The invention relates to a cartridge(10) and its use in an examination apparatus(100). A sample(1) can be introduced into an inlet(11) of the cartridge(10) and conducted through a channel(12) to a reaction chamber(13). In the reaction chamber(13), an examination of the sample takes place, for example by frustrated total internal reflection. An agent(21) is applied to the sample close to the inlet(11), wherein said agent(21) is preferably stored in a reservoir(16) at the inlet(11). In this way the filling time of the reaction chamber(13) is simultaneously used for the incubation of the sample with the agent(21). Moreover, the filling-course of the cartridge and/or the reaction chamber may preferably be determined and taken into account during the execution of the examination and/or the evaluation of the results.Type: ApplicationFiled: July 4, 2011Publication date: May 2, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Wilhelmina Maria Hardeman, Toon Hendrik Evers, Theodorus Petrus Henricus Gerardus Jansen
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Publication number: 20130095495Abstract: The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.Type: ApplicationFiled: June 14, 2011Publication date: April 18, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Gwenola Sabatte, Menno Willem Jose Prins, Toon Hendrik Evers, Wilhelmina Maria Hardeman, Joukje Garrelina Orsel
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Publication number: 20100297780Abstract: A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.Type: ApplicationFiled: July 18, 2008Publication date: November 25, 2010Applicant: Koninklijke Philips Electronics N.V.Inventors: Femke Karina De Theije, Thea Van Der Wijk, Albert Hendrik Jan Immink, Eduard Gerard Marie Pelssers, Wilhelmina Maria Hardeman, Sandra Marlin, Gordon Thomas Jowett
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Publication number: 20080164465Abstract: The electronic device comprises an organic semiconductor material in a monodomain structure on a substrate. Said semiconductor material is preferably part of a transistor, wherein the monodomain extends on the channel, i.e. from a source to a drain electrode. The material comprises a mesogenic unit with spacer groups and end groups. The end groups are preferably reactive, i.e. dienes, acrylates, oxetanes or the like. The mesogenic unit contains a central oligothiophenyl-group, rigid spacer groups, particularly acetylenes, and additional groups, for instance thiophenyl or phenyl.Type: ApplicationFiled: February 15, 2006Publication date: July 10, 2008Applicant: KONINKLIJKE PHILIPS ELECTRONICS, N.V.Inventors: Albert Jose Jan Marie Van Breemen, Peter Tobias Herwig, Jorgen Sweelssen, Caecilia Hendrina Theodora Chlon, Harmannus Franciscus Maria Schoo, Dago De Leeuw, Sepas Setayesh, Wilhelmina Maria Hardeman