Patents by Inventor Willem P. Zeijlemaker

Willem P. Zeijlemaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of culturing hybridomas
    Patent number: 4404279
    Abstract: The invention relates to a method for increasing the hybridization of cells in vitro and for increasing the production and secretion of substances, formed by such cell hybrids by adding endothelial cells and/or the supernatant of endothelial cells to a hybrid culture. In particular the invention is concerned with a method for increasing the production of monoclonal antibodies in vitro by means of a hybridoma technique by adding endothelial cells and/or the supernatant of endothelial cells to a hybridoma culture. Usually human endothelial cells and/or the supernatant of human endothelial cells are used. Finally the invention relates to endothelial cells and/or the supernatant of endothelial cells for use for increasing the hybridization of cells in vitro and for increasing the production and secretion of substances, formed by such cell hybrids, and for increasing the production of monoclonal antibodies in vitro.
    Type: Grant
    Filed: January 28, 1981
    Date of Patent: September 13, 1983
    Assignee: Stichting Vrienden van de Stichting Dr. Karl Landsteiner
    Inventors: Giulia C. B. A. Ricotti, Willem P. Zeijlemaker