Patents by Inventor William A. Andrus
William A. Andrus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11639433Abstract: Methods for fabricating rubber-based elastomeric materials are disclosed. In an embodiment, a method for fabricating a rubber-based elastomeric glove includes milling diene rubber to form first and second milled diene rubber portions; forming a first mixture by mixing a silica reinforcing component and a first antiozonant wax with the first milled diene rubber portion; forming a second mixture by mixing a second antiozonant wax with the second milled diene rubber portion; mixing the first mixture, the second mixture, and a solvent to form a viscous solution; and dipping a glove mold into the viscous solution for a selected number of dips, and evaporating the solvent from the glove mold between dips to form the rubber-based elastomeric glove, wherein the elastomeric glove has a thickness of at least about 30 mils, and wherein the elastomeric glove exhibits a flexural modulus of less than about 0.06 MPa.Type: GrantFiled: December 11, 2019Date of Patent: May 2, 2023Assignee: HONEYWELL INTERNATIONAL INC.Inventor: William Andrus Williams
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Publication number: 20200109256Abstract: Methods for fabricating rubber-based elastomeric materials are disclosed. In an embodiment, a method for fabricating a rubber-based elastomeric glove includes milling diene rubber to form first and second milled diene rubber portions; forming a first mixture by mixing a silica reinforcing component and a first antiozonant wax with the first milled diene rubber portion; forming a second mixture by mixing a second antiozonant wax with the second milled diene rubber portion; mixing the first mixture, the second mixture, and a solvent to form a viscous solution; and dipping a glove mold into the viscous solution for a selected number of dips, and evaporating the solvent from the glove mold between dips to form the rubber-based elastomeric glove, wherein the elastomeric glove has a thickness of at least about 30 mils, and wherein the elastomeric glove exhibits a flexural modulus of less than about 0.06 MPa.Type: ApplicationFiled: December 11, 2019Publication date: April 9, 2020Applicant: HONEYWELL INTERNATIONAL INC.Inventor: William Andrus Williams
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Patent number: 10538642Abstract: Elastomeric materials and articles of manufacture produced using elastomeric materials are disclosed. In an embodiment, a rubber-based elastomeric material includes a diene rubber component, a reinforcing component, and a wax component. The rubber-based elastomeric material is provided in the form of a film having a thickness of at least about 30 mils. The film exhibits a flexural modulus of less than about 0.06 MPa.Type: GrantFiled: March 22, 2013Date of Patent: January 21, 2020Assignee: HONEYWELL INTERNATIONAL INC.Inventor: William Andrus Williams
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Publication number: 20140287217Abstract: Elastomeric materials and articles of manufacture produced using elastomeric materials are disclosed. In an embodiment, a rubber-based elastomeric material includes a diene rubber component, a reinforcing component, and a wax component. The rubber-based elastomeric material is provided in the form of a film having a thickness of at least about 30 mils. The film exhibits a flexural modulus of less than about 0.06 MPa.Type: ApplicationFiled: March 22, 2013Publication date: September 25, 2014Applicant: HONEYWELL INTERNATIONAL INC.Inventor: William Andrus Williams
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Patent number: 7005478Abstract: The present invention is directed to methods of making natural or synthetic latex articles without the use of accelerators, thiurams or carbamates. The method includes making an elastomeric material by mixing a base polymer containing carboxylate groups with a carboxylic acid or derivative thereof, a divalent or trivalent metal, an amine or amino compound, and a neutralizing agent. The elastomeric material is formed into a latex article. The present invention is also directed to a latex article made according to this method. The latex article does not contain any accelerators, thiurams or carbamates.Type: GrantFiled: November 4, 2003Date of Patent: February 28, 2006Assignee: Best Manufacturing CompanyInventors: William Andrus Williams, Joyce Lee Cleveland
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Publication number: 20040092633Abstract: The present invention is directed to methods of making natural or synthetic latex articles without the use of accelerators, thiurams or carbamates. The method includes making an elastomeric material by mixing a base polymer containing carboxylate groups with a carboxylic acid or derivative thereof, a divalent or trivalent metal, an amine or amino compound, and a neutralizing agent. The elastomeric material is formed into a latex article. The present invention is also directed to a latex article made according to this method. The latex article does not contain any accelerators, thiurams or carbamates.Type: ApplicationFiled: November 4, 2003Publication date: May 13, 2004Inventors: William Andrus Williams, Joyce Lee Cleveland
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Patent number: 6706816Abstract: The present invention is directed to methods of making natural or synthetic latex articles without the use of accelerators, thiurams or carbamates. The method includes making an elastomeric material by mixing a base polymer containing carboxylate groups with a carboxylic acid or derivative thereof, a divalent or trivalent metal, an amine or amino compound, and a neutralizing agent. The elastomeric material is formed into a latex article. The present invention is also directed to a latex article made according to this method. The latex article does not contain any accelerators, thiurams or carbamates.Type: GrantFiled: July 11, 2001Date of Patent: March 16, 2004Assignee: Best Manufacturing CompanyInventors: William Andrus Williams, Joyce Lee Cleveland
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Publication number: 20030017286Abstract: The present invention is directed to methods of making natural or synthetic latex articles without the use of accelerators, thiurams or carbamates. The method includes making an elastomeric material by mixing a base polymer containing carboxylate groups with a carboxylic acid or derivative thereof, a divalent or trivalent metal, an amine or amino compound, and a neutralizing agent. The elastomeric material is formed into a latex article. The present invention is also directed to a latex article made according to this method. The latex article does not contain any accelerators, thiurams or carbamates.Type: ApplicationFiled: July 11, 2001Publication date: January 23, 2003Inventors: William Andrus Williams, Joyce Lee Cleveland
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Patent number: 6175006Abstract: A method and system for polynucleotide synthesis are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure sequences caused by chain growth from extraneous support sites, and allows lower amounts of monomer reactants to be used to achieve equal or better coupling efficiencies as those achieveable with CPG. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.Type: GrantFiled: March 30, 1999Date of Patent: January 16, 2001Assignee: The Perkin-Elmer CorporationInventors: William A. Andrus, Christie D. McCollum, Gerald Zon
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Patent number: 5935527Abstract: A method and system for polynucleotide synthesis are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure sequences caused by chain growth from extraneous support sites, and allows lower amounts of monomer reactants to be used to achieve equal or better coupling efficiencies as those achieveable with CPG. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.Type: GrantFiled: April 29, 1993Date of Patent: August 10, 1999Assignee: The Perkin-Elmer CorporationInventors: William A. Andrus, Christie D. McCollum, Gerald Zon
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Patent number: 5736626Abstract: The compounds of the invention are exemplified by the class of diglycolate synthesis supports particularly useful as support reagents for the direct synthesis of 3'-labeled polynucleotides. Generally, the compounds of the invention have the structure ##STR1## where T is an acid-cleavable hydroxyl protecting group, e.g., 4,4'-dimethoxytrityl; L.sub.1 is a linker for connecting a 3'-terminal nitrogen to carbon; L.sub.2 and L.sub.3 are linkers for connecting oxygen and carbon; W is a solid support, e.g., CPG or polystyrene; L.sub.4 is a linker for connecting the solid support to nitrogen; R.sub.1 and R.sub.2 are nitrogen substituents, e.g., hydrogen, lower alkyl, nitrogen protecting group, or label; and R.sub.3 through R.sub.7 are carbon substituents, e.g., hydrogen or lower alkyl. In a first particularly preferred embodiment, the synthesis supports of the invention are exemplified by compounds having the structure ##STR2## where DMT is 4,4'-dimethoxytrityl and W is polystyrene.Type: GrantFiled: January 29, 1996Date of Patent: April 7, 1998Assignee: The Perkin-Elmer CorporationInventors: Khairuzzaman Bashar Mullah, William A. Andrus
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Patent number: 5262530Abstract: A method and system for polynucleotide synthesis are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure sequences caused by chain growth from extraneous support sites, and allows lower amounts of monomer reactants to be used to achieve equal or better coupling efficiencies as those achieveable with CPG. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.Type: GrantFiled: July 27, 1990Date of Patent: November 16, 1993Assignee: Applied Biosystems, Inc.Inventors: William A. Andrus, Christie D. McCollum, Gerald Zon
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Patent number: 5047524Abstract: A method and system for polynucleotide synthesis and purification are provided which employ solid phase synthesis on a nonswellable porous polystyrene support by phosphoramidite or hydrogen phosphonate chemistries. The polystyrene support gives rise to fewer tritylated failure squences caused by chain growth from extraneous support sites. Consequently, currently used rapid purification techniques depending on trityl hydrophobicity give a more highly purified product. The method and system also employ nucleoside intermediates whose exocyclic amines are protected by base-labile groups which permit simultaneous cleavage and deprotection of the completed polynucleotide chain in the presence of the solid phase support. This latter feature allows practical automation of both the synthesis and purification of polynucleotides.Type: GrantFiled: December 21, 1988Date of Patent: September 10, 1991Assignee: Applied Biosystems, Inc.Inventors: William A. Andrus, Christie D. McCollum, Gerald Zon
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Patent number: 4816571Abstract: A method is provided for capping failure sequences in oligonucleotide synthesis by phosphitylation. A phosphite monoester is reacted with the 5' or 3' hydroxyl of the failure sequence between successive condensation steps in a synthesis procedure to form a 5' or 3' phosphite diester with the failure sequence. The phosphite diester substituent is inert with respect to subsequent reaction steps in the synthesis of the desired oligonucleotide product.Type: GrantFiled: June 4, 1987Date of Patent: March 28, 1989Assignee: Applied Biosystems, Inc.Inventors: William A. Andrus, J. William Efcavitch, Lincoln J. McBride