Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: A system for working biological tissue, the system comprising: a tool comprising a laser operable to perform at least one action of work; positioning means for positioning the tool relative to the biological tissue to perform the at least one action of work; a controller; storage storing electronic program instructions for controlling the controller; and an input means; wherein the controller is operable, under control of the electronic program instructions, to: receive input via the input means; process the input and, on the basis of the processing, control the positioning means and the tool to work the biological tissue.

Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: Corrosion inhibition compositions and methods useful for inhibiting corrosion are provided. The corrosion inhibition compositions comprise at least one filming agent and at least one promoting agent and the methods for inhibiting corrosion on metal surfaces utilize the disclosed corrosion inhibiting compositions.

Abstract: Corrosion inhibition compositions and methods useful for inhibiting corrosion are provided. The corrosion inhibition compositions comprise at least one coupling agent and at least one corrosion inhibitor, wherein the at least one coupling agent is at least one of one or more ether amines, one or more ether amine oxides, and at least one combination thereof, and the at least one corrosion inhibitor is at least one selected from one or more thiophosphates, one or more polyphosphate esters, one or more imidazolines, one or more quinolines, one or more alkynols, one or more alkynol derivatives, and at least one combination thereof. The methods for inhibiting corrosion on metal surfaces utilize the disclosed corrosion inhibiting compositions.

Abstract: Provided herein are oral dosage forms comprising a) a core tablet comprising (i) a drug layer comprising apremilast and hypromellose acetate succinate (HPMCAS) in an amorphous solid dispersion; and (ii) a swellable layer comprising one or more swellable polymers; and b) a coating layer disposed on the core tablet, wherein the oral dosage form surface comprises at least one drug release orifice. The disclosed oral dosage forms provide once-a-day dosing of apremilast and are suitable for treating diseases or disorders ameliorated by inhibiting phosphodiesterase subtype IV (PDE4).

Abstract: A system for working biological tissue, the system comprising: a tool comprising a laser operable to perform at least one action of work; positioning means for positioning the tool relative to the biological tissue to perform the at least one action of work; a controller; storage storing electronic program instructions for controlling the controller; and an input means; wherein the controller is operable, under control of the electronic program instructions, to: receive input via the input means; process the input and, on the basis of the processing, control the positioning means and the tool to work the biological tissue.

Abstract: A system for working biological tissue, the system comprising: a tool comprising a laser operable to perform at least one action of work; positioning means for positioning the tool relative to the biological tissue to perform the at least one action of work; a controller; storage storing electronic program instructions for controlling the controller; and an input means; wherein the controller is operable, under control of the electronic program instructions, to: receive input via the input means; process the input and, on the basis of the processing, control the positioning means and the tool to work the biological tissue.

Abstract: A method for intraoperative state analysis and classification of articular tissue comprising the steps of: sensing data of the articular tissue via a plurality of sensors situated in proximity to the articular tissue for detecting a response to a stimulus; determining state analysis and classification information through a verified means; processing the sensed data into a form adapted to be evaluated against a comparator; generating a means of predicting the state analysis and classification utilizing a historical dataset of processed information; and performing the state analysis and classification using the generated means based on processing the stimulus response obtained intraoperatively.

Abstract: Systems and methods for intraoperative implant fit analysis and longevity prediction for a prosthetic implant to be integrated with the physiological tissue of a patient, the method comprising the steps of: collection of data via a plurality of sensors situated in proximity to the tissue and implant and a plurality of data sources; determining tissue and implant state and morphology based on the collected data; generating compatibility information between the tissue and implant based on the determined tissue and implant state and morphology; processing compatibility information into a form adapted for evaluation against a pre-determined comparator; generating a means of predicting postoperative implant performance and longevity utilising the historical dataset of comparison information and postoperative results; and generating and providing corrective information for alteration of the tissue state and morphology for improved postoperative implant performance and longevity.

Abstract: An electronic device for collecting evidence during training sessions. The electronic device comprises a communications module for acquiring real-time training session data during a training session; a real-time data acquisition module for generating time-stamped training session data; an input unit for acquiring instructor rating data input by an instructor during the training session; a real-time instructor rating module for generating time-stamped instructor rating data; a storing module for storing real-time data of the training session in a data repository, including the time-stamped training session data and the time-stamped instructor rating data; a debriefing module for retrieving real-time data of a training session from the data repository, replay the real-time data on a display, and update the instructor rating data in the data repository with updated instructor rating data received from an instructor during the replay.

Abstract: A system for working biological tissue, the system comprising: a tool comprising a laser operable to perform at least one action of work; positioning means for positioning the tool relative to the biological tissue to perform the at least one action of work; a controller; storage storing electronic program instructions for controlling the controller; and an input means; wherein the controller is operable, under control of the electronic program instructions, to: receive input via the input means; process the input and, on the basis of the processing, control the positioning means and the tool to work the biological tissue.

Abstract: A handrail system for a work vehicle has a handrail including a first rail member configured to extend in first direction and a second rail member coupled to the first rail member and configured to extend in a second direction substantially perpendicular to the first direction. The handrail system also has a fold structure configured to couple the handrail to the work vehicle and move the handrail between an upright position and a folded position with respect to the work vehicle. When in the folded position, the handrail has a support surface that is elevated along a central area of the handrail higher than at least one side of the handrail.

Abstract: An electronic device for collecting evidence during training sessions. The electronic device comprises a communications module for acquiring real-time training session data during a training session; a real-time data acquisition module for generating time-stamped training session data; an input unit for acquiring instructor rating data input by an instructor during the training session; a real-time instructor rating module for generating time-stamped instructor rating data; a storing module for storing real-time data of the training session in a data repository, including the time-stamped training session data and the time-stamped instructor rating data; a debriefing module for retrieving real-time data of a training session from the data repository, replay the real-time data on a display, and update the instructor rating data in the data repository with updated instructor rating data received from an instructor during the replay.

Abstract: Embodiments include a tactile guidance system and various mechanisms for orienting and mounting the tactile guidance system on motorized vehicles such as agricultural spray vehicles. For example, a rod-shaped tactile guidance detector is positioned protruding out sideways from the inner side of each of the front wheels of a self-propelled sprayer vehicle or a tractor. The guidance system is used to detect the location of objects including crops and plants and determine a path of travel.

Abstract: Provided are certain pharmaceutical formulations of omecamtiv mecarbil and methods for their preparation and use.