Patents by Inventor William A. Edelstein

William A. Edelstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10391307
    Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: August 27, 2019
    Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
  • Patent number: 9791489
    Abstract: A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one logarithmic amplifier; at least one directional RF coupler electrically connected to the at least one power sensor; at least one RF attenuator electrically connected to the at least one RF coupler; and at least one sampling circuit electrically connected to the at least one RF attenuator and the at least one RF coupler. The at least one sampling circuit performs analog-to-digital conversion of electrical signals received to provide digitals signals for measuring the RF power level in the at least one channel.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: October 17, 2017
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Paul A. Bottomley, William Edelstein, Abdel-Monem M. El-Sharkawy, Di Qian
  • Publication number: 20170113036
    Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.
    Type: Application
    Filed: November 15, 2016
    Publication date: April 27, 2017
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
  • Patent number: 9630000
    Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: April 25, 2017
    Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore
  • Patent number: 9492651
    Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2W/kg. Related devices and methods of fabricating leads are also described.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: November 15, 2016
    Assignees: MRI Interventions, Inc., Boston Scientific Neuromodulation Corporation
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
  • Publication number: 20160220812
    Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.
    Type: Application
    Filed: February 1, 2016
    Publication date: August 4, 2016
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore
  • Patent number: 9248270
    Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.
    Type: Grant
    Filed: March 13, 2008
    Date of Patent: February 2, 2016
    Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.
    Inventors: Parag V. Karmarkar, Paul A. Bottomley, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore
  • Patent number: 8688226
    Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.
    Type: Grant
    Filed: April 29, 2013
    Date of Patent: April 1, 2014
    Assignees: Boston Scientific Neuromodulation Corporation, MRI Interventions, Inc.
    Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Edelstein, Parag V. Karmarkar
  • Publication number: 20140015547
    Abstract: A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one logarithmic amplifier; at least one directional RF coupler electrically connected to the at least one power sensor; at least one RF attenuator electrically connected to the at least one RF coupler; and at least one sampling circuit electrically connected to the at least one RF attenuator and the at least one RF coupler. The at least one sampling circuit performs analog-to-digital conversion of electrical signals received to provide digitals signals for measuring the RF power level in the at least one channel.
    Type: Application
    Filed: March 22, 2012
    Publication date: January 16, 2014
    Applicant: The Johns Hopkins University
    Inventors: Paul A. Bottomley, William Edelstein, Abdel-Monem M. El-Sharkawy, Di Qian
  • Publication number: 20130245741
    Abstract: Some embodiments are directed to MRI/RF compatible medical interventional devices. A plurality of spaced apart high impedance circuit segments are configured to have a high Impedance at a high range of radiofrequencies and a low impedance at a low range of frequencies. The high impedance circuit segments may comprise co-wound coiled inductors and can reduce, block or inhibit RJ-transmission along the lead system (20) during exposure to RF associated with a high-Held magnet MRI systems, while permuting passage of low frequency physiologic signals, treatments and/or stimuli. The devices can include at least one electrode.
    Type: Application
    Filed: April 29, 2013
    Publication date: September 19, 2013
    Applicants: MRI Interventions, Inc., BOSTON SCIENTIFIC NEUROMODULATION CORPORATION
    Inventors: Ergin Atalar, Justin Allen, Paul Bottomley, William Edelstein, Parag V. Kamarkar
  • Publication number: 20120313643
    Abstract: Disclosed herein is a magnetic resonance imaging (MRI) device noise dampening system, including an adjustable vibration dampening suspension system arranged between a gradient winding assembly of the MRI device and a support structure supported by a primary magnet assembly of an MRI device, wherein the adjustable vibration dampening suspension system comprises: a plurality of separately inflatable support elements; a vibration reducing material coupled to at least one of a plurality of connecting elements associated with a gradient winding assembly of an MRI device; and/or an acoustic noise absorbing material at least partially filling a space containing a gradient winding assembly of an MRI device.
    Type: Application
    Filed: June 13, 2012
    Publication date: December 13, 2012
    Inventors: William A. Edelstein, AbdEl-Monem El-Sharkawy
  • Publication number: 20080262584
    Abstract: MRI/RF compatible leads include at least one conductor, a respective conductor having at least one segment with a multi-layer stacked coil configuration. The lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related leads and methods of fabricating leads are also described.
    Type: Application
    Filed: March 13, 2008
    Publication date: October 23, 2008
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein, Peter Piferi, Brian Gore, J. Michael Shifflette
  • Publication number: 20080243218
    Abstract: RF/MRI compatible leads include at least one conductor that turns back on itself at least twice in a lengthwise direction, and can turn back on itself at least twice at multiple locations along its length. The at least one electrical lead can be configured so that the lead heats local tissue less than about 10 degrees Celsius (typically about 5 degrees Celsius or less) or does not heat local tissue when a patient is exposed to target RF frequencies at a peak input SAR of at least about 4 W/kg and/or a whole body average SAR of at least about 2 W/kg. Related devices and methods of fabricating leads are also described.
    Type: Application
    Filed: March 13, 2008
    Publication date: October 2, 2008
    Inventors: Paul A. Bottomley, Parag V. Karmarkar, Justin M. Allen, William A. Edelstein
  • Patent number: 7375526
    Abstract: The present invention provides an apparatus for reducing acoustic noise in a magnetic resonance imaging device including passive shielding located outside the actively shielded gradient winding elements in order to reduce the magnitude of fields that spread outside the gradient coil assembly in unwanted directions and interact with the magnet cryostat or other metallic magnet parts, inducing eddy currents that cause consequent acoustic noise. The passive shielding elements are conducting layers located on the outer radius of the cylindrical gradient coil assembly in a cylindrical magnet system, conducting layers located at the ends of the gradient coil assembly in a cylindrical magnet system, and conducting layers located inside the actively shielded gradient winding inner elements in a cylindrical magnet system. The passive shielding could also be located on separate structures that are vibrationally isolated from the magnet cryostat.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: May 20, 2008
    Inventors: William A. Edelstein, Tesfaye K. Kidane, Victor Taracilla, Tanvir N. Baig, Timothy P. Eagan, Robert W. Brown
  • Publication number: 20080094062
    Abstract: The present invention provides an apparatus for reducing acoustic noise in a magnetic resonance imaging device including passive shielding located outside the actively shielded gradient winding elements in order to reduce the magnitude of fields that spread outside the gradient coil assembly in unwanted directions and interact with the magnet cryostat or other metallic magnet parts, inducing eddy currents that cause consequent acoustic noise. The passive shielding elements are conducting layers located on the outer radius of the cylindrical gradient coil assembly in a cylindrical magnet system, conducting layers located at the ends of the gradient coil assembly in a cylindrical magnet system, and conducting layers located inside the actively shielded gradient winding inner elements in a cylindrical magnet system. The passive shielding could also be located on separate structures that are vibrationally isolated from the magnet cryostat.
    Type: Application
    Filed: October 20, 2006
    Publication date: April 24, 2008
    Inventors: William A. Edelstein, Tesfaye K. Kidane, Victor Taracilla, Tanvir N. Baig, Timothy P. Eagan, Robert W. Brown
  • Patent number: 7215122
    Abstract: The subject invention relates to a method and apparatus for producing stimulated MRI data. In an embodiment, a remote-controlled “smart phantom” can produce simulated data. The simulated data can be acquired from a MRI system. The subject device can generate control signals and send the generated control signals to secondary coils/probes placed in the subject smart phantom. The control signals determine the current flow in the secondary coils/probes, which act as local spin magnetization amplifiers and thus produce regions of variable contrast to noise ratio. The control signals can be generated with various parameters, such as BOLD models, different levels of contrast-to-noise ratio (CNR), signal intensities, and physiological signals. Comparisons can be made with the widely-used simulated data by computers. Validation of the subject smart phantom can be performed with both theoretical analysis and data of human subjects.
    Type: Grant
    Filed: October 4, 2004
    Date of Patent: May 8, 2007
    Assignee: Invivo Corporation
    Inventors: Qun Zhao, G. Randy Duensing, Hu Cheng, William A. Edelstein
  • Publication number: 20070088211
    Abstract: The subject invention relates to a method and apparatus for producing stimulated MRI data. In an embodiment, a remote-controlled “smart phantom” can produce simulated data. The simulated data can be acquired from a MRI system. The subject device can generate control signals and send the generated control signals to secondary coils/probes placed in the subject smart phantom. The control signals determine the current flow in the secondary coils/probes, which act as local spin magnetization amplifiers and thus produce regions of variable contrast to noise ratio. The control signals can be generated with various parameters, such as BOLD models, different levels of contrast-to-noise ratio (CNR), signal intensities, and physiological signals. Comparisons can be made with the widely-used simulated data by computers. Validation of the subject smart phantom can be performed with both theoretical analysis and data of human subjects.
    Type: Application
    Filed: June 13, 2006
    Publication date: April 19, 2007
    Inventors: Hu Cheng, Qun Zhao, William Edelstein, G. Duensing
  • Patent number: 7141974
    Abstract: The present invention provides an apparatus for reducing acoustic noise in a magnetic resonance imaging device including passive shielding located outside the actively shielded gradient winding elements in order to reduce the magnitude of fields that spread outside the gradient coil assembly in unwanted directions and interact with the magnet cryostat or other metallic magnet parts, inducing eddy currents that cause consequent acoustic noise. The passive shielding elements are conducting layers located on the outer radius of the cylindrical gradient coil assembly in a cylindrical magnet system, conducting layers located at the ends of the gradient coil assembly in a cylindrical magnet system, and conducting layers located inside the actively shielded gradient winding inner elements in a cylindrical magnet system. The passive shielding could also be located on separate structures that are vibrationally isolated from the magnet cryostat.
    Type: Grant
    Filed: August 25, 2004
    Date of Patent: November 28, 2006
    Inventors: William A Edelstein, Tesfaye K. Kidane, Victor Taracilla, Tanvir N. Baig, Timothy P. Eagan, Robert W. Brown
  • Publication number: 20050110490
    Abstract: The subject invention relates to a method and apparatus for producing stimulated MRI data. In an embodiment, a remote-controlled “smart phantom” can produce simulated data. The simulated data can be acquired from a MRI system. The subject device can generate control signals and send the generated control signals to secondary coils/probes placed in the subject smart phantom. The control signals determine the current flow in the secondary coils/probes, which act as local spin magnetization amplifiers and thus produce regions of variable contrast to noise ratio. The control signals can be generated with various parameters, such as BOLD models, different levels of contrast-to-noise ratio (CNR), signal intensities, and physiological signals. Comparisons can be made with the widely-used simulated data by computers. Validation of the subject smart phantom can be performed with both theoretical analysis and data of human subjects.
    Type: Application
    Filed: October 4, 2004
    Publication date: May 26, 2005
    Inventors: Qun Zhao, G. Duensing, Hu Cheng, William Edelstein
  • Patent number: 6894498
    Abstract: The present invention provides an apparatus for reducing acoustic noise in a magnetic resonance imaging device including a suspension element including at least one resilient element and an active drivable element for applying a compensating force to reduce vibration transmission. The active drivable element is positioned so as to not directly support the weight of the gradient coil assembly, which avoids applying strong forces to relatively fragile active drivable elements, such as piezoelectric force transducers. Force signals for the active drivable element are derived in a feed-forward manner from the applied gradient waveform or from motion of the gradient coil assembly bracket. Alternatively, the active drivable element can be driven by signals derived from measured vibration or other motion of parts of the MRI magnet, gradient coils or rf coils.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: May 17, 2005
    Assignee: MRScience LLC
    Inventor: William A. Edelstein