Patents by Inventor William A. Maltese

William A. Maltese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vacuole-inducing compounds, methods of making and using the same
    Patent number: 11602531
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: March 14, 2023
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20210038586
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: October 20, 2020
    Publication date: February 11, 2021
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • VACUOLE-INDUCING COMPOUNDS, METHODS OF MAKING AND USING THE SAME
    Publication number: 20200000789
    Abstract: Vacuole- or exosome-inducing indole-based chalcone and substituted triazole-hydrazone compounds that induce endosomal vacuolization and increase exosome yield, but do not trigger growth arrest or cell death, and methods of making and using are described.
    Type: Application
    Filed: January 31, 2018
    Publication date: January 2, 2020
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Zehui Li, Christopher J. Trabbic, Paul W. Erhardt
  • Materials and methods useful to induce vacuolization, cell death, or a combination thereof
    Patent number: 9061994
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: June 23, 2015
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Jean H. Overmeyer, Christopher Trabbic
  • Materials And Methods Useful To Induce Vacuolization, Cell Death, Or A Combination Thereof
    Publication number: 20150152049
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Application
    Filed: February 6, 2015
    Publication date: June 4, 2015
    Applicant: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Jean H. Overmeyer, Christopher Trabbic
  • Materials and methods useful to induce cell death via methuosis
    Patent number: 9028796
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: May 12, 2015
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Michael W. Robinson, Jean H. Overmeyer
  • Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof
    Patent number: 9023871
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: May 5, 2015
    Assignee: The University of Toledo
    Inventors: William A. Maltese, Paul W. Erhardt, Christopher Trabbic, Jean H. Overmeyer
  • Materials and Methods Useful to Induce Cell Death via Methuosis
    Publication number: 20140322128
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Application
    Filed: February 24, 2012
    Publication date: October 30, 2014
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: William A. Maltese, Paul W. Erhardt, Michael W. Robinson, Jean H. Overmeyer
  • Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof
    Publication number: 20140213615
    Abstract: The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein.
    Type: Application
    Filed: April 7, 2014
    Publication date: July 31, 2014
    Applicant: THE UNIVERSITY OF TOLEDO
    Inventors: William A. Maltese, Paul W. Erhardt, Christopher Trabbic, Jean H. Overmeyer