Patents by Inventor William A. Metz, Jr.

William A. Metz, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1H-pyrrolo[2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase I?
    Patent number: 7626027
    Abstract: The present invention discloses and claims compounds of formula (I) wherein M is N, and K and L are each C with the remaining substituents further defined herein. These compounds are effective as inhibitors of human casein kinase I?, and as such are useful in the treatment of central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: December 1, 2009
    Assignee: Aventis Pharmaceuticals Inc
    Inventors: William A. Metz, Jr., Frank Halley, Gilles Dutruc-Rosset, Yong Mi Choi-Sledeski, Gregory Bernard Poli, David Marc Fink, Gilles Doerflinger, Bao-Guo Huang, Ann Marie Gelormini, Juan Anotonio Gamboa, Andrew Giovanni, Joachim E. Roehr, Joseph T. Tsay, Fernando Camacho, William Joseph Hurst, Stephen Wayne Harnish, Yulin Chiang
  • Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon
    Patent number: 7402672
    Abstract: The present invention discloses and claims compounds of formula (I) as inhibitors of human casein kinase IF, and methods of using said compounds of formula (I) for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) and methods for the preparation of compounds of formula (I) are also disclosed and claimed.
    Type: Grant
    Filed: December 1, 2004
    Date of Patent: July 22, 2008
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: William A. Metz, Jr., Frank Halley, Gilles Dutruc-Rosset, Yong Mi Choi-Sledeski, Gregory Bernard Poli, David Marc Fink, Gilles Doerflinger, Bao-Guo Huang, Ann Marie Gelormini, Juan Antonio Gamboa, Andrew Giovanni, Joachim E. Roehr, Joseph T. Tsay, Fernando Camacho, William Joseph Hurst, Stephen Wayne Harnish, Yulin Chiang
  • Elastase inhibitors
    Patent number: 6693072
    Abstract: This invention relates to compounds which are inhibitors of elastase, particularly human neutrophil elastase. The inhibitors are short, synthetic peptides in which the P2 moiety is substituted with various nitrogen-containing heterocyclic groups. As inhibitors of human neutrophil elastase, the compounds are useful in the treatment of a patient afflicted with a neutrophil associated inflammatory disease.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: February 17, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Steven L. Gallion, William A. Metz Jr., Joseph P. Burkhart, Michael R. Angelastro, Norton P. Peet
  • Heterocycle substituted propenoic acid derivatives as NMDA antagonist
    Patent number: 6180786
    Abstract: The present invention is new 3-(heterocyclic)-propenoic acid derivatives and pharmaceutical compositions thereof. These new 3-(heterocyclic)-propenoic acid derivatives are useful as NMDA antagonist.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: January 30, 2001
    Assignee: Hoechst Marion Roussel, Inc.
    Inventor: William A. Metz, Jr.
  • Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
    Patent number: 6008196
    Abstract: This invention relates to compounds which are inhibitors of elastase, particularly human neutrophil elastase, and to novel processes for making the same. As inhibitors of human neutrophil elastase, the compounds are useful in the treatment of a patient afflicted with a neutrophil associated inflammatory disease.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: December 28, 1999
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Timothy T. Curran, Joseph P. Burkhart, Michael R. Angelastro, Norton P. Peet, William A. Metz, Jr.