Patents by Inventor William A. Palmisano

William A. Palmisano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nested methylation-specific polymerase chain reaction cancer detection method
    Patent number: 7214485
    Abstract: A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or “nested” polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.
    Type: Grant
    Filed: August 24, 2001
    Date of Patent: May 8, 2007
    Assignee: Lovelace Respiratory Research Institute
    Inventors: Steven A. Belinsky, William A. Palmisano
  • Cancer monitoring by aberrant promotor methylation of the transcription factor genes PAX5 alpha PAX5 beta, novel loop helix loop protein, novel gene 2, and beta 3 genes
    Publication number: 20040248171
    Abstract: PAX5 alpha and PAX5 beta and other genes as markers for cancer detection. A PCR-based technique of methylated CpG island amplification, followed by representational difference analysis, for identifying genes methylated in human cancer. The genes PAX5 alpha and PAX5 beta, novel loop helix loop protein, and a novel gene 2, and beta3 genes when methylated serve as markers for detecting, monitoring, diagnosing and prognosticating breast, colon, and lung cancer in humans. Amplification methods, including primer sequences for methylation specific polymerase chain reaction, are disclosed.
    Type: Application
    Filed: March 25, 2004
    Publication date: December 9, 2004
    Applicant: Lovelace Respiratory Research Institute
    Inventors: William A. Palmisano, Steven A. Belinsky
  • Nested methylation-specific polymerase chain reaction cancer detection method
    Publication number: 20040038245
    Abstract: A molecular marker-based method for monitoring and detecting cancer in humans. Aberrant methylation of gene promoters is a marker for cancer risk in humans. A two-stage, or “nested” polymerase chain reaction method is disclosed for detecting methylated DNA sequences at sufficiently high levels of sensitivity to permit cancer screening in biological fluid samples, such as sputum, obtained non-invasively. The method is for detecting the aberrant methylation of the p16 gene, O 6-methylguanine-DNA methyltransferase gene, Death-associated protein kinase gene, RAS-associated family 1 gene, or other gene promoters. The method offers a potentially powerful approach to population-based screening for the detection of lung and other cancers.
    Type: Application
    Filed: February 14, 2003
    Publication date: February 26, 2004
    Inventors: Steven A Belinsky, William A Palmisano