Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The cancer may be prostate cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, glioblastoma or endometrial cancer. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the B1SP fusion protein may include a sema domain, a structural stabilization domain; and a half life extending moiety.

Abstract: Provided are methods, uses and pharmaceutical compositions for treatment of cancer with a B1SP fusion protein in a biologically effective amount sufficient to cause cell death of a prostate cancer cell or to inhibit proliferation of the prostate cancer cells. The cancer may be prostate cancer, breast cancer, ovarian cancer, bladder cancer, kidney cancer, glioblastoma or endometrial cancer. The prostate cancer may be an androgen receptor (AR) positive prostate cancer and the B1SP fusion protein may include a sema domain, a structural stabilization domain; and a half life extending moiety.

Abstract: An actuator (1) for a hand-held aerosol container fitted centrally at its top with a dispensing valve, the actuator having: (i) a cup-shaped over-cap (3) attachable to the container and having a top wall defining a gap through which a spray channel passes, the gap restricting lateral movement of the spray channel; (ii) a spray channel (4) in fluid connection with the valve; (iii) an actuator button (5) having a finger pad from which a keel depends; the keel dependent from the finger pad of the button (5) being able to press down onto the spray channel (4) and the spray channel (4) on to the valve after the first slide movement of the button (5), but not before; whereby the actuator button (5) has a distinct first slide movement that puts it into an orientation in which a second depression movement causes release of the contents of the associated dispenser and in that the force required for the first slide movement of the actuator button (5) is at least 5N.

Abstract: An actuator (1) for a hand-held aerosol container fitted centrally at its top with a dispensing valve, said actuator comprising: (i) a cup-shaped over-cap (3) attachable to the container and comprising a top wall defining a gap through which a spray channel passes, said gap restricting lateral movement of the spray channel; (ii) a spray channel (4) in fluid connection with the valve; (iii) an actuator button (5) comprising a finger pad from which a keel depends; the keel dependent from the finger pad of the button (5) being able to press down onto the spray channel (4) and the spray channel (4) on to the valve after the first slide movement of the button (5), but not before; whereby the actuator button (5) has a distinct first slide movement that puts it into an orientation in which a second depression movement causes release of the contents of the associated dispenser and in that the force required for the first slide movement of the actuator button (5) is at least 5N.

Abstract: An ergonomically excellent hand-held aerosol dispenser (1) comprising an aerosol container (3) and an attached spray through cap (2), the container (3) having a valve (15) at its top and a waisted section (4) towards its upper end, the upper expansion of the waisted section (4) smoothly continuing into the attached cap (2), the attached cap (2) reaching a maximum cross-sectional dimension which decreases further up and having: (i) an actuator button (6) located on its surface (8) above its maximum cross-sectional dimension, said button (6) being angled upwards at from 15° to 50°; (ii) a spray aperture (7) on the opposite side of the cap (2) from the actuator button (6); and (iii) an associated spray channel (15) providing a fluid connection between the valve (15) on the container (3) and the spray aperture (7); the dimensions of the dispenser (1) allowing the consumer to grip the dispenser (1) around the waisted section (4) of the container and, with the same hand, press upon the actuator button (6) with an i

Abstract: A unique component furniture assembly for securing furniture components in wall furniture systems comprises a light-weight metal track, along which glides a novel fastening assembly which receives screws, threaded support posts and the like and to which a given furniture component is secured. The fastening assembly includes a block, preferably a plastic nut, carried by a basket. The block is suspended within the basket by a coil spring or other bias means. Relative expansion of the block and the basket by action of the spring causing contact with inner surfaces of the track causing the fastening assembly to remain stationary, though moveable on the track. The present furniture assembly further includes a plurality of selectively spaced detents, preferably raised protuberances, on the inside bottom surface of the track which function to lock the fastening assembly to the track and are used to align fastening assemblies on adjacent and opposing tracks.