Abstract: The technology described herein includes methods and uses for quaternary ammonium, specifically an organosilane quaternary ammonium or quat, and particularly AIVIOSILQ™ quat to provide persistent disinfectant and anti-microbial protection. Uses include skin (derma) and medical applications.

Abstract: The present disclosure provides improved methods for controlled cyclization of peptoid dimers to form N,N?-2,5-diketopiperazines (N,N?-2,5-DKPs) with significant selectivity. In at least some examples, selectivity is based on a serendipitous conglomeration of slow exchange of amide rotamers, steric repulsion from the degree of ?-substitution, and the geometric bulk of an amine nucleophile. By varying reaction conditions, the selectivity of the reaction and formation of a particular N,N?-2,5-DKP can be switched. The cyclization works in the presence of a variety of protection groups and diverse functionalities. The teachings herein provide techniques for synthesizing N,N?-2,5-DKPs that can be readily docked with drug candidates for shuttling across the blood brain barrier. This method provides a facile way to produce substituted DKPs containing groups ready for post-modification to include docking drug candidates.

Abstract: A wireless network includes at least a pair of nodes that are configured to communicate with each other by transmitting and receiving one or more millimeter-wave beams through an obstruction and through unobstructed air. In accordance with an exemplary embodiment of the network, the nodes include small, phased-array antennas and transceivers, configured with radio electronics to mitigate the path loss through certain obstructions, such as walls, floors, barriers within buildings, and the attenuation from free-space path-loss, including moisture in air (humidity). The network may include multiple pairs of nodes to form one or more wireless communication paths through various obstructions. This may allow a high-speed wireless network to be established within a structure, such as a building, without requiring additional cabling or wiring.

Abstract: An off-grid electrical system has at least one power source selected from the group consisting of photovoltaic cells, wind turbines, or fluid turbines. At least one generator electrically connected to the at least one power source, wherein the at least one power source converts one or more environmental factors into energy processed by the at least one generator. A plurality of battery banks, wherein at least one battery bank is storing energy from the at least one generator, while a second battery bank is discharging energy. A micro controller controlling the charging and discharging of the plurality of battery banks, wherein the micro controller simultaneously transfers operations of the plurality of battery banks between charging and discharging.

Abstract: Apparatuses, systems, and methods for wireless millimeter-wave communications are disclosed. An apparatus is configured to rotate about an axis so as to improve transfer of wireless signals. The apparatus includes a support having a first side and a second side. A first phased array antenna is mounted to the support facing away from the first side. A second phased array antenna mounted to the support facing away from the second side. The apparatus further includes a means for rotating the support, such as a hinge or a pivot. By rotating the support in the field, the coverage of the wireless signals to/from at least one of the phased array antennas may be improved.

Abstract: Apparatuses, systems, and methods that allow millimeter-wave communication signals to pass efficiently and reliably through obstructions are disclosed. An apparatus includes a first wireless transceiver and a first phased array antenna coupled to the first wireless transceiver. A second phased array antenna is also coupled to the first wireless transceiver. The apparatus additionally includes a second wireless transceiver and a third phased array antenna coupled to the second wireless transceiver. The third phased array antenna is adapted to emit a third millimeter wave beam through an obstruction. A fourth phased array antenna is also coupled to the second wireless transceiver. The fourth phased array antenna is adapted to receive a fourth millimeter wave beam through the obstruction. A controller is included in the apparatus for managing data transfer between the first wireless transceiver and the second wireless transceiver so that a fully duplexed communication path is available between the antennas.

Abstract: A surgical instrument includes an optical fiber having a proximal end and a distal end, the optical fiber configured to emit light at the distal end. The surgical instrument also includes at least one scattering material coupled to the proximal end, the distal end, or a combination of both the proximal end and the distal end.

Abstract: An integrated ocular fluid management system that, in one instance, includes a first chamber connected to a first input line and a first output line. A second chamber is connected to a second input line and a second output line. A first pump communicates with the first output line. A second pump communicates with the second input line. A first pressure regulator communicates with the first chamber. A second pressure regulator communicates with the second chamber. A first diaphragm is in the first chamber; and a second diaphragm is in the second chamber. A first controller controls at least one of the first pump and the first pressure regulator to maintain the first diaphragm in a predetermined position. A second controller controls operation of at least one of the second pump and the second pressure to maintain the second diaphragm in a predetermined position.

Abstract: A wireless network includes at least a pair of nodes that are configured to communicate with each other by transmitting and receiving one or more millimeter-wave beams through an obstruction and through unobstructed air. In accordance with an exemplary embodiment of the network, the nodes include small, phased-array antennas and transceivers, configured with radio electronics to mitigate the path loss through certain obstructions, such as walls, floors, barriers within buildings, and the attenuation from free-space path-loss, including moisture in air (humidity). The network may include multiple pairs of nodes to form one or more wireless communication paths through various obstructions. This may allow a high-speed wireless network to be established within a structure, such as a building, without requiring additional cabling or wiring.

Abstract: An ophthalmic surgical cutting apparatus for cutting biological material including a handle, an outer tube attached to the handle and having a closed tip, a port formed in a side wall of the outer tube with a cusp formed by two or more intersecting surfaces, and an inner tube slidable within the outer tube and having a longitudinal axis and an open tip. The inner tube is in fluid communication with the handle, and the cusp of the port and the open tip interface during a cutting motion to fracture and cut biological materials and direct cut materials radially inward into the port.

Abstract: A surgical hand tool includes a handle that has an inner cavity. The handle has a proximal end and a distal end. The surgical hand tool also includes a primary tube extending outwardly from the cavity at the distal end, a reinforcing slider slidably disposed over the primary tube, and a biasing member coupled to the handle that biases the reinforcing slider away from the handle. The surgical hand tool also includes a retention mechanism coupled to the handle, the retention mechanism configured to engage and disengage with the reinforcing slider to control relative movement between the reinforcement slider and the handle.

Abstract: A communication network includes nodes configured into a wireless ring network operating at one or more millimeter-wave frequencies. At least one of the nodes is configured to send and receive millimeter-wave wireless signals through an obstruction. In accordance with an exemplary embodiment of the network, one or more of the nodes may include small, phased-array antennas and transceivers, configured with radio electronics to mitigate the path loss through certain obstructions, such as walls, floors, ceilings, and other barriers within buildings, as well as attenuation from free-space path-loss, including moisture in air (humidity). The network may include multiple pairs of nodes to form one or more wireless communication paths through various obstructions. This may allow a high-speed, wireless, multi-ring network to be established, for example, within a structure, such as a building, without requiring additional cabling or wiring.

Abstract: Apparatuses, systems, and methods for wireless millimeter-wave communications are disclosed. An apparatus is configured to rotate about an axis so as to improve transfer of wireless signals. The apparatus includes a support having a first side and a second side. A first phased array antenna is mounted to the support facing away from the first side. A second phased array antenna mounted to the support facing away from the second side. The apparatus further includes a means for rotating the support, such as a hinge or a pivot. By rotating the support in the field, the coverage of the wireless signals to/from at least one of the phased array antennas may be improved.

Abstract: Apparatuses, systems, and methods that allow millimeter-wave communication signals to pass efficiently and reliably through obstructions are disclosed. An apparatus includes a first wireless transceiver and a first phased array antenna coupled to the first wireless transceiver. A second phased array antenna is also coupled to the first wireless transceiver. The apparatus additionally includes a second wireless transceiver and a third phased array antenna coupled to the second wireless transceiver. The third phased array antenna is adapted to emit a third millimeter wave beam through an obstruction. A fourth phased array antenna is also coupled to the second wireless transceiver. The fourth phased array antenna is adapted to receive a fourth millimeter wave beam through the obstruction. A controller is included in the apparatus for managing data transfer between the first wireless transceiver and the second wireless transceiver so that a fully duplexed communication path is available between the antennas.

Abstract: Ocular fluid management systems and methods of operating the same. One ocular fluid management system includes a chamber, a diaphragm, a sensor, and a controller. The chamber includes a first portion and a second portion. The first portion is connected to an input line for receiving fluids into the first portion and an output line for discharging fluids from the first portion. The diaphragm is contained in the chamber and changes position based on a pressure difference between the first and second portions. The sensor detects a position of the diaphragm and transmits a signal based on the detected position. The controller is configured to receive the signal and control operation of at least one of a peristaltic pump and a vacuum pump based on the signal to maintain the diaphragm in a predetermined position.

Abstract: Fault analysis for an electric network having a plurality of multi-phase buses is performed by computing equivalent circuits for the multi-phase buses of interest. Each equivalent circuit includes an N×N impedance matrix, N corresponding to the number of phases of the multi-phase bus for which that equivalent circuit is computed. Elements of the impedance matrices are determined based on voltages resulting from a plurality of experimental current injection vectors and a factorized pre-fault admittance matrix. The pre-fault admittance matrix represents nodal admittance of the multi-phase buses without faults. A fault current injection vector for each multi-phase bus and fault type of interest is determined based on the equivalent circuit determined for that multi-phase bus. A fault voltage vector for each multi-phase bus and fault type of interest is determined based on the factorized pre-fault admittance matrix and the fault current injection vector determined for that multi-phase bus and fault type.

Abstract: A ballast water treatment system. Implementations may include an intake screen, a ballast water intake pump coupled to the intake screen, a screen filter coupled to an outlet of the ballast water intake pump, and a multi-cartridge filter system coupled to the screen filter and with one or more ballast tanks A ballast water dump pump may be coupled with the one or more ballast tanks. The multi-cartridge filter system may include two or more cartridge filters including a quaternary organosilane coating produced from a quaternary ammonium organosilane reagent.

Abstract: An integrated ocular fluid management system that, in one instance, includes a first chamber connected to a first input line and a first output line. A second chamber is connected to a second input line and a second output line. A first pump communicates with the first output line. A second pump communicates with the second input line. A first pressure regulator communicates with the first chamber. A second pressure regulator communicates with the second chamber. A first diaphragm is in the first chamber; and a second diaphragm is in the second chamber. A first controller controls at least one of the first pump and the first pressure regulator to maintain the first diaphragm in a predetermined position. A second controller controls operation of at least one of the second pump and the second pressure to maintain the second diaphragm in a predetermined position.

Abstract: A steerable laser probe including an optical fiber, a flexible tubular sleeve positioned co-axially with the flexible tubular sleeve relative to an axis, and a straightening sleeve positioned co-axially with the flexible tubular sleeve and the optical fiber relative to the axis, and positioned between the flexible tubular sleeve and the optical fiber along the axis.

Abstract: A multichannel application specific integrated circuit (ASIC) for interfacing with an array of photodetectors in a positron emission tomography (PET) imaging system includes a front end circuit configured to be coupled to the photodetectors and to receive discrete analog signals therefrom. The ASIC further includes a time discriminating circuit operably coupled to the front end circuit and configured to generate a hit signal based on a combination of the discrete analog signals, and an energy discriminating circuit operably coupled to the front end circuit and configured to generate a summed energy output signal based on each of the discrete analog signals and summed row and column output signals based on each of the discrete analog signals. The summed energy output signal represents an energy level of the detected radiation in the array of photodetectors, and the summed row and column output signals represent a location of the detected radiation.