Abstract: Compounds and compositions that have a Protein Recognition Moiety bound to an electrophile for the selective covalent modification of targeted proteins to treat disorders mediated by the targeted protein are described.

Abstract: A battery cabinet with a plurality of spaced apart shelves of equal width and depth. Each shelf supports a removable battery module. In turn, each module has a fixed adapter that holds batteries as a battery bank where the module and adapter occupy most of the space between shelves. Battery cells are vertically or horizontally aligned with terminals joined to comb-shaped straps with blades joined to battery terminals. The space between blades allows for thermal expansion without wear on terminals.

Abstract: A method of delivering a health care active having the steps of administering to a mammal in need of a health benefit or a treatment for a health condition a personal health care article and consuming the article. The article contains one or more filaments that contain a backbone material, a health care active and optionally aesthetic agents, extensional aids, plasticizers, and crosslinking agents.

Abstract: Various embodiments include a filling apparatus that can be connected to a valve on a keg, such as a Sankey-D valve, and can be used to pour alcohol and other liquids into the keg, which may be pre-filled with a non-alcoholic drink mix. The filling apparatus has an upper structure which is coupled to a lower portion configured to mate with a keg valve. The filling apparatus may be designed to depress portions of the keg valve to allow for both filling and venting of the keg simultaneously. The filling apparatus may further be designed with features to prevent liquid escape during degassing of the keg. The filling apparatus may include a Sankey-D coupler or a coupler with a probe portion as the lower body portion.

Abstract: A bone screw comprises a shaft defining a longitudinal axis and a minor diameter. The shaft including a core having an angled surface relative to the axis. The angled surface extending from the minor diameter adjacent a proximal portion of the shaft to a distal portion of the shaft, and a wall disposed about the angled surface. The wall including at least one thread having an external thread form. In some embodiments, systems, spinal constructs, surgical instruments and methods are disclosed.

Abstract: Embodiments described herein provide techniques to enable the dynamic reconfiguration of memory on a general-purpose graphics processing unit. One embodiment described herein enables dynamic reconfiguration of cache memory bank assignments based on hardware statistics. One embodiment enables for virtual memory address translation using mixed four kilobyte and sixty-four kilobyte pages within the same page table hierarchy and under the same page directory. One embodiment provides for a graphics processor and associated heterogenous processing system having near and far regions of the same level of a cache hierarchy.

Abstract: In an aspect an apparatus for geometric part searching is presented. An apparatus includes at least a processor and a memory communicatively connected to the at least a processor. At least a processor is configured to generate a search index as a function of a plurality of part specification files. At least a processor is configured to receive an input part specification file. At least a processor is configured to generate a query for an input part as a function of an input part specification file and a search index. A query is configured to output a comparison of an input part specification file to a part estimation specification file. At least a processor is configured to identify a matching part estimation file from a plurality of query results.

Abstract: A hard surface cleaning composition, methods of cleaning a hard surface with a low hysteresis composition and disposable premoistened pads for cleaning hard surfaces are provided. The hard surface cleaning composition includes from 0.01 wt. % to 7 wt. % of a solvent selected from the group consisting of a propylene glycol phenyl ether, a dipropylene glycol phenyl ethers and mixtures thereof and at least 92% water. The cleaning composition has a pH from about 3.5 to 9.5 and is free of anionic surfactant and alkanolamine.

Abstract: A hard surface cleaning composition, methods of cleaning a hard surface with a low hysteresis composition and disposable premoistened pads for cleaning hard surfaces are provided. The hard surface cleaning composition includes from 0.01 wt. % to 7 wt. % of a solvent selected from the group consisting of a propylene glycol phenyl ether, a dipropylene glycol phenyl ethers and mixtures thereof and at least 92% water. The cleaning composition has a pH from about 3.5 to 9.5 and is free of anionic surfactant and alkanolamine.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating cystic fibrosis, e.g., in subjects having a mutation resulting in F508del, are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating alpha-1 antitrypsin deficiency (AATD) are described.

Abstract: The disclosure provides, e.g., compositions, systems, and methods for targeting, editing, modifying, or manipulating a host cell's genome at one or more locations in a DNA sequence in a cell, tissue, or subject. Gene modifying systems for treating phenylketonuria (PKU) are described.

Abstract: Exemplary embodiments include a filling apparatus that can be connected to a valve on a keg, such as a Sankey-D valve, and can be used to pour alcohol and other liquids into the keg, which may be pre-filled with a non-alcoholic drink mix. The filling apparatus has an upper structure which is coupled to a lower portion configured to mate with a keg valve. The filling apparatus may be designed to depress portions of the keg valve to allow for both filling and venting of the keg simultaneously. The filling apparatus may further be designed with features to prevent liquid escape during degassing of the keg. The filling apparatus may include a Sankey-D coupler or a coupler with a probe portion as the lower body portion.

Abstract: A woven geotextile fabric utilizes a plurality of yarns including machine direction field yarns, cross machine direction field yarns, machine direction rib yarns, and cross machine direction rib yarns. The plurality of yarns is integrally woven together. The machine direction rib yarns and the cross machine direction rib yarns cooperatively define an integrated geotextile grid integrally within the woven geotextile fabric. The machine direction field yarns and the cross machine direction field yarns cooperatively define fabric areas in a field of the integrated geotextile grid generally between the machine direction rib yarns and the cross machine direction rib yarns.

Abstract: Exemplary embodiments include a filling apparatus that can be connected to a valve on a keg, such as a Sankey-D valve, and can be used to pour alcohol and other liquids into the keg, which may be pre-filled with a non-alcoholic drink mix. The filling apparatus has an upper structure coupled to a valve assembly which is coupled to a lower structure configured to mate with a keg valve. The filling apparatus may be designed to depress portions of the keg valve to allow for both filling and venting of the keg simultaneously. The filling apparatus may include a Sankey-D coupler or a coupler with a probe portion as the lower body portion.

Abstract: Exemplary embodiments include an apparatus that can be connected to a valve on a keg, such as a Sankey-D valve, and can be used to add gas into the keg to mix the contents, which may be including alcoholic spirts and a non-alcoholic drink mix. The apparatus has an upper structure which is coupled to a lower portion configured to mate with a keg valve. The filling apparatus may be designed to depress the ball valve and ring valve portions of the keg valve to allow for both the addition of gas and venting of gas from the keg simultaneously.

Abstract: Disclosed are exemplary embodiments of woven silt fences including integrally woven pockets for support posts. In exemplary embodiments, a woven silt fence fabric includes one or more integrated pockets integrally woven within the woven silt fence fabric. The one or more integrated pockets are configured for receiving one or more support posts therein. In exemplary embodiments, a woven silt fence comprises the woven silt fence fabric and one or more support posts configured to be received within corresponding ones of the one or more integrated pockets integrally woven within the woven silt fence fabric. The one or more support posts may be configured to be positioned within corresponding ones of the one or more integrated pockets and driven into the ground for supporting the woven silt fence without requiring any fasteners for attachment of the one or more support posts to the woven silt fence fabric.

Abstract: An interactive assessment system for measuring neurologic function and method of use are provided herein. The interactive assessment system includes an interactive assessment device comprising an interactive display defining longitudinal and lateral columns of interactive nodes, each interactive node is coupled to a sensor, and has an illumination mode and a delumination mode. The interactive assessment system also including a processing device in communication with the interactive assessment device and configured to perform logic functions based upon user inputs on the interactive assessment device. The processing device includes memory wherein previously input interactions with the interactive assessment device are stored and tagged as successes, failure, or interaction events.