Abstract: The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

Abstract: A system for reducing carbonaceous material is disclosed. The system includes a compartment configured to receive the carbonaceous material. An auger is located within the compartment and centered about a drive shaft. A rotational drive mechanism is coupled to the drive shaft and configured to rotate the auger to enable the carbonaceous material to travel through the compartment as the auger is rotated. A plurality of lifting arms are coupled to a surface of the auger. The lifting arms are configured to lift and stir the carbonaceous material as the auger is rotated. At least one microwave generator is coupled to the compartment and configured to radiate the carbonaceous material as it travels through the compartment to reduce the carbonaceous material into at least one chemical component of the carbonaceous material.

Abstract: Novel compounds which selectively bind to the ?-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the ?-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known ?-opioid receptor selectors as analgesics.

Abstract: Clustering is routinely applied in the exploratory analysis of microarray data. Missing entries arise from blemishes on the microarrays. The present invention provides a new method, and computer program and/or computer product thereof to impute missing values. The method involves the steps of clustering microarray data by partitioning the data into a select number of clusters, wherein each data point is iteratively moved from one cluster to another, until two consecutive iterations have resulted in the same partition pattern; obtaining a select number of estimates of the data in the clusters by probabilistic interference; and averaging the select number of estimates to obtain missing values in the microarray data. The method is superior to other imputation models as measured by root mean squared errors.

Abstract: An active vibration control (AVC) system includes a shaft-driven gearbox mounted force generator (GMFG) mounted to a main rotor transmission. The GMFGs receive shaft power from an output shaft driven by the main rotor transmission and/or engine-to-transmission gearbox to avoid separate drive motors.

Abstract: Disclosed is a novel pharmacophore and novel inotropic compositions created from the novel pharmacophore. Also disclosed are methods of making and using the novel pharmacophore and method of use of novel compositions to treat heart diseases by inhibiting Na, K-ATPase.

Abstract: The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

Abstract: A night sight includes a notched bottom portion, permitting the use of a large objective lens for maximized light gathering capability while also permitting the night sight to be mounted with its center line relatively close to the center line of the barrel of the weapon with which it is used. This configuration permits the night sight to be mounted so that its center line is the same as the center line of a daytime telescopic sight used in conjunction with the night sight. The night sight includes a focusing assembly having decreased sensitivity to tilt or decenter, and a collimator mounted within a spherical bearing so that the collimator may be precisely aligned during assembly of the night sight. The night sight thereby ensures that an image viewed through the night sight appears to originate from the same angle as that with which the image entered the objective lens, and further resists a need to compensate for parallax during aiming.

Abstract: A golf putter having a bent shaft and designed to be used with an individual facing the intended travel direction of the launched golf ball. The golf putter comprises a bent shaft configuration, an upper handle assembly having a rotating upper grip, a fixed lower grip, and a putter head assembly. In operation, the right-handed individual will hold the golf putter with the left hand grasping the rotating handle assembly and the right hand grasping the lower fixed grip. The left hand and the rotating upper grip are held against the abdomen for stability purposes. Using the right hand, the individual rotates the shaft rearward and then forward to make contact between the putter head and the golf ball. The present invention golf putter comprises unique symmetry allowing a left-handed individual to use the golf putter simply by reversing the hand positions described. By enabling the individual to face the cup, the proposed invention provides better sight alignment and enables a more natural swing.

Abstract: An active vibration control (AVC) system includes a shaft-driven gearbox mounted force generator (GMFG) mounted to a main rotor transmission. The GMFGs receive shaft power from an output shaft driven by the main rotor transmission and/or engine-to-transmission gearbox to avoid separate drive motors.

Abstract: A method and device for reducing vibratory noise in a system with an integral rotating member includes independently operable drive means for controlling the angular velocity of at least two masses. Control signals manipulate the drive means to allow each mass to rotate at optimal speed, direction and phase for reducing the noise induced in the system by the rotating member.

Abstract: The present invention generally relates to the field of plant genetics and protein biochemistry. More specifically, the present invention relates to modified proteins having an increased number of essential amino acids. The present invention provides proteins modified to have an increased number of essential amino acids, nucleic acid sequences encoding the enhanced proteins, and methods of designing, producing, and using the same. The present invention also includes compositions, transformed host cells, transgenic plants, and seeds containing the enhanced proteins, and methods for preparing and using the same.

Abstract: An apparatus and method to minimize acoustic vibration in a vehicle due to impulsive gear clash loads. Sensors are mounted on the vehicle and are used to sense vehicle vibration generated by the gear clash loads. A first gear, having a plurality of teeth and a second gear, also having a plurality of teeth, are disposed such that upon rotation of the first and second gears, certain ones of the second gear teeth mesh with certain ones of the first gear teeth. An actuator, which is coupled to the first gear, drives the first gear and generates torque pulses. A controller is coupled to the actuator and controls the torque pulses that are transmitted to the first gear. The torque pulses generated by the actuator are adjusted in magnitude and phase so that the first gear teeth vibrate at a predetermined frequencies thereby reducing vibrations and peak tooth loading caused by the meshing of the first gear teeth and the second gear teeth.

Abstract: The DO-DROP golf putter is a bent shaft putter, designed to be used with the golfer facing the golf hole. The upper handle assembly will consist of a rotating grip. The lower grip will be fixed. The right-handed golfer will hold the putter with the left hand grasping the rotating handle assembly and the right hand grasping the lower fixed grip. The left hand, which is grasping the handle assembly, will be held against the abdomen. Using the right hand, the golfer will rotate the shaft rearward and then forward to make contact between the putter head and the golf ball. The symmetry of the DO-DROP golf putter enables it to be used by a left-handed person by reversing the hand positions described. By enabling the golfer to face the cup, the proposed invention provides better sight alignment and enables a more natural swing.

Abstract: An active mount is provided for use in a rotary wing aircraft between each of the gearbox and airframe mounting locations for mechanically suspending the airframe from the gearbox. The active mount comprises first and second linear hydraulic actuators each having a principal axis. The length of the actuators is variable along the principal axis for providing relative movement between the airframe and the gearbox. The principal axes of the actuators are adapted to lie in the directional planes of the primary forces necessary for supporting the airframe and acting on the transmission gearbox mounting locations for providing movement of the gearbox relative to the airframe in the planes at a frequency for reducing the transfer of vibration through the active mount to the airframe. A system for reducing vibration in the rotary wing aircraft further comprises a hydraulic system for supplying a controlled flow of pressurized hydraulic fluid to the actuators.

Abstract: An active mount is provided for use in a rotary wing aircraft between each of the gearbox and airframe mounting locations for mechanically suspending the airframe from the gearbox. The active mount comprises first and second linear hydraulic actuators each having a principal axis. The length of the actuators is variable along the principal axis for providing relative movement between the airframe and the gearbox. The principal axes of the actuators are adapted to lie in the directional planes of the primary forces necessary for supporting the airframe and acting on the transmission gearbox mounting locations for providing movement of the gearbox relative to the airframe in the planes at a frequency for reducing the transfer of vibration through the active mount to the airframe. A system for reducing vibration in the rotary wing aircraft further comprises a hydraulic system for supplying a controlled flow of pressurized hydraulic fluid to the actuators.

Abstract: An actuator is disclosed for an active vibration and noise control system in an aircraft. The actuator is configured to attach a vibrating component, such as a gearbox mounting foot, to an aircraft support structure. The actuator is actuated by the control system to control the transmission of vibratory loads from the gearbox foot. The actuator includes a housing and a mounting member. The housing mounts to the aircraft. The mounting member attaches to the vibrating component within the aircraft. A piston arrangement is attached to the housing and includes a sleeve located within the housing, and a piston slidably disposed within the sleeve. A bearing assembly engages the mounting member with the piston. The bearing assembly includes a first bearing located between the mounting member and an inner bearing member. The first bearing is adapted to transmit axial motions between the mounting member and the piston.

Abstract: An improved flatting agent comprising an inorganic hydrogel having a pore volume of at least 1.0 ml/g, an average particle size in the range 1 to 10 microns, and a particle size distribution such that when the flatting agent is dispersed in a coating, the fineness of grind is at least 4.75 on the Hegman scale. The inorganic hydrogel flatting agents of this invention are prepared by milling an inorganic hydrogel under controlled temperature conditions wherein a volatiles content of at least 40 weight percent is maintained, to produce inorganic hydrogel particles characterized by a pore volume of at least 1.0 ml/g, an average particle size in the range of 1 to 10 microns, and a particle size distribution such that when the flatting agent is dispersed in a coating, the fineness of grind is at least 4.75 on the Hegman scale.

Abstract: An actuator is disclosed for an active vibration and noise control system in an aircraft. The actuator is configured to attach a vibrating component, such as a gearbox mounting foot, to an aircraft support structure. The actuator is actuated by the control system to control the transmission of vibratory loads from the gearbox foot. The actuator includes a housing and a mounting member. The housing mounts to the aircraft. The mounting member attaches to the vibrating component within the aircraft. A piston arrangement is attached to the housing and includes a sleeve located within the housing, and a piston slidably disposed within the sleeve. A bearing assembly engages the mounting member with the piston. The bearing assembly includes a first bearing located between the mounting member and an inner bearing member. The first bearing is adapted to transmit axial motions between the mounting member and the piston.

Abstract: A hub mounted actuation system for providing control of a portion of a rotor blade, such as a flap, on a rotorcraft. The rotor blade is attached to a rotor shaft that rotates with respect to an airframe. The hub mounted actuation system includes a stationary support mounted to the airframe and a rotary support attached to the rotor shaft for concomitant rotation therewith. At least one hub actuator rotates in combination with the rotor blade and includes a piston which is slidable within a housing. The piston and housing define a pressure chamber within the actuator which contains a fluid to be pressurized. A displacement control device is disposed between the stationary support and the rotary support for controlling movement of the piston within the housing. A linkage connects the hub actuator to the portion of the blade to be controlled. The linkage is adapted to displace the blade portion as a function of the movement of the piston within the housing.