Abstract: In general, techniques and systems for detecting acoustic signals and generating phonocardiograms are described. In one example, a system may include an acoustic sensor configured to detect an acoustic signal from a heart of a patient. The system may also include a sensing module configured to detect an electrical signal from the heart of the patient via two or more electrodes and at least one processor configured to generate a composite phonocardiogram based the acoustic signal and the electrical signal detected over a plurality of cardiac cycles of the heart, wherein the composite phonocardiogram is generated for a representative cardiac cycle. The system may be provided in a single device or multiple devices configured to transmit information between the devices.

Abstract: An electronic stethoscope includes a housing configured for hand-held manipulation, a transducer supported by the housing and configured to sense auscultation signals at a first location, and a headset coupled to the housing and configured to deliver audio corresponding to the auscultation signals through earpieces on the headset. The electronic stethoscope further includes a processor disposed in the housing and configured to convert the auscultation signals to first digital signals representative of the auscultation signals and to wirelessly transmit the first digital signals from the electronic stethoscope via a secure digital network to a second location such that the audio corresponding to the auscultation signals is provided to headsets of one or more additional electronic stethoscopes at the second location in substantial real time with the sensing of the auscultation sounds at the first location.

Abstract: An electronic stethoscope includes a housing configured for hand-held manipulation, a transducer supported by the housing and configured to sense auscultation signals at a first location, and a headset coupled to the housing and configured to deliver audio corresponding to the auscultation signals through earpieces on the headset. The electronic stethoscope further includes a processor disposed in the housing and configured to convert the auscultation signals to first digital signals representative of the auscultation signals and to wirelessly transmit the first digital signals from the electronic stethoscope via a secure digital network to a second location such that the audio corresponding to the auscultation signals is provided to headsets of one or more additional electronic stethoscopes at the second location in substantial real time with the sensing of the auscultation sounds at the first location.

Abstract: In general, techniques and systems for detecting acoustic signals and generating phonocardiograms are described. In one example, a system may include an acoustic sensor configured to detect an acoustic signal from a heart of a patient. The system may also include a sensing module configured to detect an electrical signal from the heart of the patient via two or more electrodes and at least one processor configured to generate a composite phonocardiogram based the acoustic signal and the electrical signal detected over a plurality of cardiac cycles of the heart, wherein the composite phonocardiogram is generated for a representative cardiac cycle. The system may be provided in a single device or multiple devices configured to transmit information between the devices.

Abstract: An electronic stethoscope includes a housing configured for hand-held manipulation, a transducer supported by the housing and configured to sense auscultation signals at a first location, and a headset coupled to the housing and configured to deliver audio corresponding to the auscultation signals through earpieces on the headset. The electronic stethoscope further includes a processor disposed in the housing and configured to convert the auscultation signals to first digital signals representative of the auscultation signals and to wirelessly transmit the first digital signals from the electronic stethoscope via a secure digital network to a second location such that the audio corresponding to the auscultation signals is provided to headsets of one or more additional electronic stethoscopes at the second location in substantial real time with the sensing of the auscultation sounds at the first location.

Abstract: Methods of providing at least one reagent for use in a device for processing sample material, delivering at least one reagent to a device for processing sample material, and adding at least one reagent to at least one of the steps in a process for detecting or assaying a nucleic acid; a support film coated with a dry reagent layer; and a device for processing sample material having a support film coated with a dry reagent layer contained within at least one chamber of the device are disclosed.

Abstract: A system and method for processing sample processing devices. The system can include a base plate adapted to rotate about a rotation axis. The system can further include a cover including a first projection, and a housing. A portion of the housing can be movable with respect to the base plate between an open position and a closed position, and can include a second projection. The first projection and the second projection can be adapted to be coupled together when the portion is in the open position and decoupled when the portion is in the closed position. The method can include coupling the cover to the portion of the housing, moving the portion of the housing from the open position to the closed position, and rotating the base plate about the rotation axis.

Abstract: A biomedical sensor system. The system can include a sensor adapted to create a signal based on a physiological characteristic from a subject, and a hub adapted to receive the signal from the sensor. The signal can include at least one of an electromagnetic signal, an electrical signal, an acoustic signal, a mechanical signal, a thermal signal, and a chemical signal. The system can further include a connector adapted to couple the sensor and the hub, the connector having a variable length, such that the sensor and the hub can be positioned a variable distance apart by changing the length of the connector. The connector can be adapted to provide a pathway between the sensor and the hub for the signal. A method of applying a biomedical sensor system to a subject can include changing the length of the variable-length connector to provide an appropriate distance between the sensor and the hub, and coupling the sensor to the subject.

Abstract: A multifunction medical device includes a housing configured for hand-held manipulation, a processing unit within the housing, and a connector on the outer surface of the housing. The connector is coupled to the processing unit and operable to connect to a plurality of different types of medical sensors. The processing unit is configured to determine a type of a medical sensor coupled to the connector.

Abstract: Methods for processing sample materials. Methods of the present disclosure can include providing a device including a process chamber array, the process chamber array including a loading chamber and a process chamber; providing sample material in the process chamber array; moving the sample material within the process chamber array by rotating the device; providing paramagnetic particles within the sample material located in the process chamber array; providing a magnet proximate the device; and rotating the device such that the paramagnetic particles within the sample material are subjected to the magnetic field of the magnet during rotation of the device.

Abstract: A stretchable conductive connector. The conductive connector can include a viscoelastic support member having a variable length, and a conductor coupled to the support member. The conductor can include at least one bend to accommodate the variable length of the viscoelastic support member.

Abstract: Methods and devices for the thermal processing of samples are disclosed, including sample processing devices featuring an overflow region for retaining excess fluid, as well as portable sealing apparatuses for occluding channels in a sample processing device.

Abstract: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group of process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.

Abstract: Methods and devices for the thermal processing of samples are disclosed, including portable, integrated processing assemblies for occluding channels in a fluidic device.

Abstract: An electronic stethoscope includes a housing configured for hand-held manipulation, a transducer supported by the housing and configured to sense auscultation signals at a first location, and a headset coupled to the housing and configured to deliver audio corresponding to the auscultation signals through earpieces on the headset. The electronic stethoscope further includes a processor disposed in the housing and configured to convert the auscultation signals to first digital signals representative of the auscultation signals and to wirelessly transmit the first digital signals from the electronic stethoscope via a secure digital network to a second location such that the audio corresponding to the auscultation signals is provided to headsets of one or more additional electronic stethoscopes at the second location in substantial real time with the sensing of the auscultation sounds at the first location.

Abstract: Processing devices that include one or more process arrays with thermal transfer structures that can be used alone or in conjunction with gravity/rotation to transport fluids within a microfluidic system. The thermal transport function can be accomplished by changing the temperature of one or more chambers to create a vacuum to draw fluids in selected directions within the process array. The methods and apparatus of the present invention may provide the ability to move fluids in a direction that is against the direction of gravity or any centrifugal forces generated by rotating a processing device using the thermal transfer structures. In other words, fluids may be moved against the direction of gravity or towards the axis of rotation using the thermally-activated vacuum.

Abstract: Methods and devices for thermal processing of multiple samples at the same time are disclosed. The sample processing devices provide process arrays that include conduits useful in distributing sample materials to a group of process chambers located in fluid communication with the main conduits. The sample processing devices may include one or more of the following features in various combinations: deformable seals, process chambers connected to the main conduit by feeder conduits exiting the main conduit at offset locations, U-shaped loading chambers, and a combination of melt bonded and adhesively bonded areas.