Patents by Inventor William Bishai

William Bishai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BCG BASED VACCINE COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20240009292
    Abstract: The present disclosure relates to a BCG based therapeutic agent using a BCG strain that overexpresses the STING agonist, c-di-AMP. This BCG strain, called BCG-disA-OE, enhances the elevated trained immunity of macrophages and promotes early anti-viral Type I interferon responses in a subject, providing protection against viral infections such as primary respiratory infections and SARS-CoV-2 infection.
    Type: Application
    Filed: October 1, 2021
    Publication date: January 11, 2024
    Inventors: Alok Singh, Peter Um, Keira Cohen, William Bishai, Rullin Wang, Srinivasan Yegnasubramanian, Trinity J. Bivalacqua
  • Methods of using isotopically labelled isoniazid for the diagnosis of mycobacterial infections
    Patent number: 9453253
    Abstract: The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopically labeled isoniazid.
    Type: Grant
    Filed: March 7, 2013
    Date of Patent: September 27, 2016
    Assignees: STC.UNM, THE JOHNS HOPKINS UNIVERSITY
    Inventors: Graham Timmins, Seong Choi, Zachary Sharp, Viorel Atudorei, Mamoudou Maiga, William Bishai
  • METHODS OF USING ISONIAZID FOR THE DIAGNOSIS OF LUNG INFECTIONS
    Publication number: 20150104819
    Abstract: The present invention is directed to methods of diagnosing the presence or absence of a bacterial infection in a patient, in particular, a tuberculosis infection, by measuring exhaled, isotopically labeled nitrogen gas after administration of isotopic ally labeled isoniazid.
    Type: Application
    Filed: March 7, 2013
    Publication date: April 16, 2015
    Inventors: Graham Timmins, Seong Choi, Zachary Sharp, Viorel Atudorei, Mamoudou Maiga, William Bishai
  • Rationally improved isoniazid and ethionamide derivatives and activity through selective isotopic substitution
    Patent number: 8921569
    Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: December 30, 2014
    Assignees: STC.UNM, The Johns Hopkins University
    Inventors: Graham Timmins, Sharon Master, Vojo P Deretic, William Bishai
  • RATIONALLY IMPROVED ISONIAZID AND ETHIONAMIDE DERIVATIVES AND ACTIVITY THROUGH SELECTIVE ISOTOPIC SUBSTITUTION
    Publication number: 20130150415
    Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.
    Type: Application
    Filed: February 6, 2013
    Publication date: June 13, 2013
    Applicants: The John Hopkins University, STC.UNM
    Inventors: Graham TIMMINS, Sharon Masters, Vojo P. Deretic, William Bishai
  • RATIONALLY IMPROVED ISONIAZID AND ETHIONAMIDE DERIVATIVES AND ACTIVITY THROUGH SELECTIVE ISOTOPIC SUBSTITUTION
    Publication number: 20110218220
    Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.
    Type: Application
    Filed: August 20, 2008
    Publication date: September 8, 2011
    Applicants: STC.UNM, THE JOHN HOPKINS UNIVERSITY
    Inventors: Graham Timmins, Sharon Master, Vojo P. Deretic, William Bishai
  • Hollow fiber technique for in vivo study of cell populations
    Publication number: 20060182685
    Abstract: The present invention relates to a method of using hollow fibers to evaluate cellular changes in vivo. A method for evaluating cellular changes in vivo in response to administration of a drug or drugs of interest is provided. The hollow fiber technique is also used to evaluate cellular changes in a microorganism in vivo. The technique is further used to evaluate cellular changes in a microorganism in vivo in response to administration of a drug or drugs of interest. A vaccine and method of vaccination are also provided.
    Type: Application
    Filed: September 6, 2005
    Publication date: August 17, 2006
    Inventors: William Bishai, Petros Karakousis