Abstract: The invention provides novel bis-pyridylpyridones which are antagonists at the melanin-concentrating hormone receptor 1 (MCHR1), pharmaceutical compositions containing them, processes for their preparation, and their use in therapy and for the treatment of obesity and/or diabetes.

Abstract: This invention relates to the compound of Formula I and pharmaceutically acceptable salts thereof: (R)-N*6*-ethyl-6,7-dihydro-5H-indeno[5,6-d]thiazole-2,6-diamine This invention also relates to methods of making, methods of using, and pharmaceutical compositions comprising the compound of Formula I and salts thereof.

Abstract: A web browser communicates through a secure local proxy to a web server that has an interface for secure communications. The application server has an application program conforming to the CGI programming model that can run continuously as a process and can maintain state information, such as pointers to next records, thus requiring less computational and memory overhead for a succession of requests.

Abstract: An in-ground installed pipe system, laid in expansive type soils, that has a plastic-like wrapping of the main pipe area and a plastic-like covered cushion layer of the joint connections, to provide protection to a pipe system against pipe movement and joint connection disruption, during the swelling and shrinkage process of the surrounding expansive soil, during seasonal variations of moisture content of the soil. The plastic-like wrapping of the pipe section is usually installed prior to installing the pipe into the trench. The plastic-like covered cushion layer is installed around the pipe joint connection, in the trench, after the pipe is installed into the end of the previously laid pipe section.