Patents by Inventor William Carle Horne

William Carle Horne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of inhibiting osteoclastogenesis
    Patent number: 6682739
    Abstract: Methods of inhibiting osteoclastogenesis and the activity of osteoclasts are disclosed. Methods of treating patients who have diseases characterized bone loss are disclosed. The present invention also provides peptides and peptide analogues designed from a binding loop of a member of the tumor necrosis factor receptor (TNF-R) superfamily. According to the methods, an amount of an inhibitor effective to inhibit osteoclastogenesis is administered to the patient. Methods of modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems in an individual are disclosed. The methods comprise the step of administering to the individual an amount of an inhibitor effective to modulating dendritic cell maturation, T cell proliferation, and/or CD40 receptor systems.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: January 27, 2004
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Mark I. Greene, Ramachandran Murali, Kazuhiro Aoki, William Carle Horne, Roland Baron