Abstract: In one embodiment, provided is a sound attenuating barrier having a core structure between face sheets with a mass attached to at least one face sheet, and having a spatially varied stiffness distribution and/or a spatially varied density. The sound attenuating barrier may include at least one face sheet and/or core having a spatially varied stiffness distribution and/or a spatially varied mass distribution. In one embodiment, a sound attenuating barrier is provided having a core structure between face sheets with a mass structure attached to at least one face sheet, with the core/and or face sheet(s) being constructed to design an effective vibration length as well as enable a variable local stiffness and mass across the sound attenuating barrier such that the sandwich structure provides variable resonance frequency responses and broadband coverage.

Abstract: Composite materials with high damping and high stiffness at relatively low density. These materials include three-dimensional structures of interconnected ligaments, which have multiple concentric layers alternating between stiff constraining layers and soft damping layers, so that bulk deformation of the structure results in high local shear strain and correspondingly high bulk damping.

Abstract: A three-dimensional microlattice structure includes a series of interconnected struts extending along at least three different directions, a series of intermediate nodes defined at intersections between the struts, and a basal plane structure extending laterally between and interconnecting at least two of the nodes. The basal plane structure may be configured to transversely and rotationally constrain the nodes to increase the overall compressive strength and stiffness of the microlattice structure. In one embodiment, the interconnected struts are arranged into an array of ordered unit cells.

Abstract: Methods of manufacturing a structure having at least one plated region and at least one unplated region. The method includes plating a metal on a polymer structure having a first region accepting the metal and a second region unreceptive to the metal plating. The first region may include fully-cured polymer optical waveguides and the second region may include partially-cured polymer optical waveguides. The first region may include a first polymer composition and the second region may include a second polymer composition different than the first polymer composition.

Abstract: An apparatus for maintaining an environmental state of a working surface includes: a first micro-truss layer including: a plurality of first struts extending along a first direction; a plurality of second struts extending along a second direction; and a plurality of third struts extending along a third direction, the first, second, and third struts interpenetrating one another at a plurality of nodes, the first, second, and third struts interpenetrating one another at non-perpendicular angles, the apparatus having a contact surface configured to contact the working surface and having an open porosity configured to allow air to flow to the contact surface, wherein a total surface area of the contact surface is between about 1% and about 50% of a total surface area of the working surface.

Abstract: Vaccine protection against acute or chronic viral infection is facilitated by using as an adjuvant or immuno-stimulant, a dsRNA together with an anti-influenza vaccine.

Abstract: An apparatus that may entirely be contained in a glovebox for the removal of at least one contaminant from an inert atmosphere. The apparatus includes a body, a media in the body for the removal of at least one of the contaminants from the inert atmosphere flowing through the media, a fan for causing the inert atmosphere to flow through the media and body, and a motor for driving the fan. The apparatus may be provided in combination with a glovebox. A method of purification of the inert atmosphere using such an apparatus is also provided.

Abstract: An electrical circuit to interrupt a DC current includes a bypass switch and an AC high voltage breaker which includes interrupters that are rated for carrying a current having a value of the DC current for a period of time less than or equal to continuous duty. The first interrupter is electrically coupled in parallel with the bypass switch. A making switch causes a cancellation current to flow from an energy source through the second interrupter, and through the first interrupter, in addition to the DC current. The AC high voltage breaker is adapted to a DC service as the DC current in addition to the cancellation current causes an arc quench which allows the AC high voltage breaker to cause the interruption of the DC current in the electrical circuit. A method for interrupting a DC current flowing in an AC high voltage circuit breaker is also described.

Abstract: A magnetic holding device uses an array of switchable magnets. A carrier holds the array of switchable magnets to form a working surface. Each switchable magnet has a coil of wire surrounding a magnetizable core element. The array is arranged in groups of magnets. A circuit is coupled to the coils to selectively magnetize and demagnetize each group of switchable magnets to selectively independently place each group into one of these states: an ON state that configures the selected group to have a first magnetic polarity at the working surface, an ON state that configures the selected group to have an opposite magnetic polarity at the working surface, and an OFF state that configures the magnets in the selected group to have no magnetism at the working surface. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.

Abstract: A novel form of Rugged dsRNA with a unique composition and physical characteristics was identified with high specificity of binding to TLR3, which conveys an important range of therapeutic opportunities. Unlike the previous known antiviral Ampligen® (poly I, poly C12,U) the new and improved form (poly I, poly C30,U) has a reduced tendency to form branched dsRNA which results in increased bioactivity due to an increased ability to bind TLR3 receptor. Pharmaceutical formulations containing the new nucleic acid as active ingredients and methods of treatment are also provided. The invention also provides a description of the physicochemical properties of this novel form of Rugged dsRNA and a method for its preparation in substantially pure form. DsRNAs acting thru TLR3 receptor activation are potent antiviral compounds as well as anticancer agents; also through secondary immunomodulation they can enhance the bioactivity of vaccines and also treat autoimmune disorders.

Abstract: A DC superconducting coaxial transmission system provides electrical transmission of 5,000 megawatts of energy while simultaneously delivering liquid hydrogen. The transmission system includes a coaxial transmission segment including an inner superconductor, an outer superconductor disposed in surrounding relation to the inner conductor, and a dielectric insulator disposed between the inner superconductor and the outer superconductor. Liquid hydrogen surrounds the superconductors. Three phase transformers and poly phase rectifier/inverters provide a DC voltage source to the superconductors from the electrical grid. In one embodiment, a switching circuit connected between the voltage source and the superconductor injects a cancellation current component into the direct current flow.

Abstract: Composite materials with high damping and high stiffness at relatively low density. These materials include three-dimensional structures of interconnected ligaments, which have multiple concentric layers alternating between stiff constraining layers and soft damping layers, so that bulk deformation of the structure results in high local shear strain and correspondingly high bulk damping.

Abstract: Durable, impact-resistant structural coatings with dewetting and anti-icing properties are disclosed. The coatings possess a self-similar structure with two feature sizes that are tuned to affect the wetting of water and freezing of water on the surface. Dewetting and anti-icing performance is simultaneously achieved in a structural coating comprising multiple layers, with each layer including (a) a continuous matrix; (b) porous voids, dispersed within the matrix, to inhibit wetting of water; and (c) nanoparticles, on pore surfaces, that inhibit heterogeneous nucleation of water. These structural coatings utilize low-cost and lightweight materials that can be rapidly sprayed over large areas. If the surface is damaged during use, fresh material will expose a coating surface that is identical to that which was removed, for extended lifetime.

Abstract: The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsRNA) having specific biological activities, which includes acting as a selective agonist for activation of the Toll-like receptor 3. Its “rugged” molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation). This structure appears to be responsible for increased efficacy of dsRNA in therapeutic applications and improved biological activity (e.g., used as an immunoregulatory agent). Medicaments, processes for their manufacture, and methods for their use are provided herein.