Patents by Inventor William Choy

William Choy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of infection by enveloped virus with calix(N)arene compounds
    Patent number: 5441983
    Abstract: A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachements to the ring, with polar substitutent having a terminal carboxylate, phosphate, or sulfonate groups, including esters and amides which are cleavable in vivo. The compound may be administered orally, or topically, e.g., for treatment of herpes virus.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: August 15, 1995
    Assignee: Genelabs Incorporated
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu, William Choy, Jen Chen
  • Antithrombotic treatment with calix(n)arene compounds
    Patent number: 5409959
    Abstract: A method of inhibiting thrombus formation in a mammalian subject. The method involves administering to the subject a therapeutically effective dose of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituents having terminal sulfonate groups, including esters and amides which are cleavable in vivo.
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: April 25, 1995
    Assignee: Genelabs Incorporated
    Inventors: Kou M. Hwang, You M. Qi, Su-Ying Liu, Thomas C. Lee, William Choy, Jen Chen
  • Preparation of 4.beta.- amino podophyllotoxin compounds
    Patent number: 5338867
    Abstract: A method of preparing a 4'-0-demethy-4.beta.-NHR podophyllotoxin, where R is an aryl or dialkyl amino alkyl group, is disclosed. The method includes reacting H.sub.2 NR under basic conditions with a mixture of .alpha. and .beta. epimers of 4'-0-demethyl-4-bromo-podophyllotoxin, to form an epimeric mixture of the 4'-0-demethyl-4-NHR-podophyllotoxin compounds, removing acidic impurities which bind to silica gel in a dichloromethane solvent, and crystallizing 4'-0-demethyl-4.beta.-NHR-podophyllotoxin from its .alpha. epimer.
    Type: Grant
    Filed: April 24, 1992
    Date of Patent: August 16, 1994
    Assignee: Genelabs Technologies, Inc.
    Inventors: William Choy, Jen Chen, Bijan Almassian
  • Chiral boron enolate reagents
    Patent number: 4405802
    Abstract: Chiral boron enolates are provided having the formulae: ##STR1## wherein R.sub.2 B is 9-borobicyclo[3.3.1]non-9-yl(BBN) or R is n-butyl, cyclopentyl, or another alkyl group.The boron enolates can be condensed with aldehydes to produce aldol stereospecific product which includes a .beta.-hydroxy-.alpha.-methyl carbonyl unit in the product structure.
    Type: Grant
    Filed: February 22, 1982
    Date of Patent: September 20, 1983
    Assignee: Massachusetts Institute of Technology
    Inventors: Satoru Masamune, William Choy