Patents by Inventor William F. DeGrado

William F. DeGrado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DESIGNED PROTEINS FOR LIGAND BINDING
    Publication number: 20230253066
    Abstract: Disclosed herein, inter alia, are methods and systems for optimizing protein ligand interactions.
    Type: Application
    Filed: July 21, 2021
    Publication date: August 10, 2023
    Inventors: William F. DeGrado, Nicholas Polizzi
  • Inhibitors of alpha 2 beta 1 integrin and methods of use thereof
    Patent number: 11643388
    Abstract: Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: May 9, 2023
    Assignees: The Regents of the University of California, ShangPharma Innovation Inc.
    Inventors: Dean Sheppard, William F. DeGrado, Aparna Sundaram, Hyunil Jo, Richard Beresis, Marc Adler
  • Inhibitors of integrin alpha 2 beta 1 and methods of use
    Patent number: 11597727
    Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: March 7, 2023
    Assignee: The Regents of the University of California
    Inventors: Dean Sheppard, Aparna Sundaram, William F. DeGrado, Hyunil Jo
  • INHIBITORS OF ALPHA 2 BETA 1 INTEGRIN AND METHODS OF USE THEREOF
    Publication number: 20220411366
    Abstract: Disclosed herein, inter alia, are inhibitors of alpha 2 beta 1 integrin and methods of using the same.
    Type: Application
    Filed: April 30, 2021
    Publication date: December 29, 2022
    Inventors: Dean Sheppard, William F. DeGrado, Aparna Sundaram, Hyunil Jo, Richard Beresis, Marc Adler
  • Alpha-5 beta-1 inhibitors
    Patent number: 11530180
    Abstract: The disclosure provides, inter alia, alpha-5 beta-1 inhibitors, pharmaceutical compositions comprising alpha-5 beta-1 inhibitors, methods for treating diseases using alpha-5 beta-1 inhibitors, and processes for making alpha-5 beta-1 inhibitors.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: December 20, 2022
    Assignees: The Regents of the University of California, Shanghai ChemPartner Co., Ltd.
    Inventors: Dean Sheppard, William F. DeGrado, Hyunil Jo, Aparna Sundaram, Richard Beresis
  • INHIBITORS OF INTEGRIN ALPHA 2 BETA 1 AND METHODS OF USE
    Publication number: 20210387986
    Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 2 beta 1 and methods of using the same.
    Type: Application
    Filed: March 13, 2019
    Publication date: December 16, 2021
    Inventors: Dean Sheppard, Aparna Sundaram, William F. DeGrado, Hyunil Jo
  • ALPHA-5 BETA-1 INHIBITORS
    Publication number: 20210171455
    Abstract: The disclosure provides, inter alia, alpha-5 beta-1 inhibitors, pharmaceutical compositions comprising alpha-5 beta-1 inhibitors, methods for treating diseases using alpha-5 beta-1 inhibitors, and processes for making alpha-5 beta-1 inhibitors.
    Type: Application
    Filed: December 9, 2020
    Publication date: June 10, 2021
    Inventors: Dean Sheppard, William F. DeGrado, Hyunil Jo, Aparna Sundaram, Richard Beresis
  • Inhibitors of integrin alpha 5 beta 1 and methods of use
    Patent number: 10836720
    Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 5 beta 1 and methods of using the same.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: November 17, 2020
    Assignee: The Regents of the University of California
    Inventors: Dean Sheppard, Aparna Sundaram, William F. Degrado, Hyunil Jo, Joel McIntosh
  • INHIBITORS OF INTEGRIN ALPHA 5 BETA 1 AND METHODS OF USE
    Publication number: 20190144386
    Abstract: Disclosed herein, inter alia, are inhibitors of integrin alpha 5 beta 1 and methods of using the same.
    Type: Application
    Filed: March 31, 2017
    Publication date: May 16, 2019
    Inventors: Dean Sheppard, Aparna Sundaram, William F. Degrado, Hyunil Jo, Joel McIntosh
  • Anti-alphavbeta1 integrin inhibitors and methods of use
    Patent number: 10214522
    Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: February 26, 2019
    Assignee: The Regents of the University of California
    Inventors: William F. DeGrado, Dean Sheppard, Hyunil Jo, Nilgun Isik Reed, Youzhi Tang, Joel McIntosh
  • Anti-alphavbeta1 integrin compounds and methods
    Patent number: 10131658
    Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.
    Type: Grant
    Filed: March 29, 2016
    Date of Patent: November 20, 2018
    Assignee: The Regents of the University of California
    Inventors: William F. DeGrado, Dean Sheppard, Hyunil Jo, Nilgun Isik Reed, Youzhi Tang
  • ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS
    Publication number: 20180312500
    Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.
    Type: Application
    Filed: March 29, 2016
    Publication date: November 1, 2018
    Inventors: William F. DeGrado, Dean Sheppard, Hyunil Jo, Nilgun Isik Reed, Youzhi Tang
  • Inhibitors targeting drug-resistant influenza A
    Patent number: 9884832
    Abstract: Provided are compounds according to formula (Ia) or (Ib) as described herein, that are capable of modulating the activity of influenza viruses (e.g., influenza A virus), for example, via interaction with the M2 transmembrane protein, and other similar viroporins. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds according to according to formulas (Ia?) or (Ib), as described herein.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: February 6, 2018
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Jizhou Wang, Jun Wang, Hyunil Jo, Belgin Canturk
  • ANTI-ALPHAVBETA1 INTEGRIN COMPOUNDS AND METHODS
    Publication number: 20160376266
    Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.
    Type: Application
    Filed: March 29, 2016
    Publication date: December 29, 2016
    Inventors: William F. DeGrado, Dean Sheppard, Hyunil Jo, Nilgun Isik Reed, Youzhi Tang
  • Influenza A virus inhibition
    Patent number: 9464075
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: October 11, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • Inhibition of influenza M2 proton channel
    Patent number: 9453005
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: September 27, 2016
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • ANTI-ALPHAVBETA1 INTEGRIN INHIBITORS AND METHODS OF USE
    Publication number: 20160264566
    Abstract: Provided herein, inter alia, are methods and compositions for inhibiting ?v?1 integrin and for treating fibrosis.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 15, 2016
    Inventors: William F. DeGrado, Dean Sheppard, Hyunil Jo, Nilgun Isik Reed, Youzhi Tang, Joel McIntosh
  • Inhibitors of the influenza A virus M2 proton channel
    Patent number: 9403777
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: August 2, 2016
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang
  • Facially Amphiphilic Polymers and Oligomers and Uses Thereof
    Publication number: 20160151314
    Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
    Type: Application
    Filed: December 3, 2015
    Publication date: June 2, 2016
    Inventors: William F. DEGRADO, Gregory N. TEW, Michael L. KLEIN, Dahui LIU, Jing YUAN, Sungwook CHOI
  • Adamantane analogs
    Patent number: 9301950
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: April 5, 2016
    Assignee: The Trustees Of The University of Pennsylvania
    Inventors: William F. DeGrado, Jun Wang