Patents by Inventor William G. Dunphy

William G. Dunphy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Claspin proteins and methods of use thereof
    Patent number: 7037678
    Abstract: Claspin proteins and nucleotides encoding Claspin proteins are provided. Also provided is a method for identifying a compound that modulates cell cycle progression. A method is further provided for modulating cell cycle progression.
    Type: Grant
    Filed: October 17, 2001
    Date of Patent: May 2, 2006
    Assignee: California Institute of Technology
    Inventors: Akiko Kumagai, William G. Dunphy
  • Checkpoint-activating oligonucleotides
    Publication number: 20040018603
    Abstract: The present invention provides polypeptides (Cds1) that are involved in regulating the progression of the cell cycle. The polypeptides are activated by double-stranded DNA and phosphorylated in response to the presence of double-stranded DNA. Also provided are polynucleotides encoding Cds1 polypeptidese and methods for modulating cell cycle progression in a cell.
    Type: Application
    Filed: July 11, 2003
    Publication date: January 29, 2004
    Inventors: Zijian Guo, William G. Dunphy
  • Checkpoint-activating oligonucleotides
    Patent number: 6593110
    Abstract: The present invention provides polypeptides (Cds1) that are involved in regulating the progression of the cell cycle. The polypeptides are activated by double-stranded DNA and phosphorylated in response to the presence of double-stranded DNA. Also provided are polynucleotides encoding Cds1 polypeptidese and methods for modulating cell cycle progression in a cell.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: July 15, 2003
    Assignee: California Institute of Technology
    Inventors: Zijian Guo, William G. Dunphy
  • Claspin proteins and methods of use thereof
    Publication number: 20020151030
    Abstract: Claspin proteins and nucleotides encoding Claspin proteins are provided. Also provided is a method for identifying a compound that modulates cell cycle progression. A method is further provided for modulating cell cycle progression.
    Type: Application
    Filed: October 17, 2001
    Publication date: October 17, 2002
    Inventors: Akiko Kumagai, William G. Dunphy
  • Checkpoint-activating oligonucleotides
    Publication number: 20020086392
    Abstract: The present invention provides polypeptides (Cds1) that are involved in regulating the progression of the cell cycle. The polypeptides are activated by double-stranded DNA and phosphorylated in response to the presence of double-stranded DNA. Also provided are polynucleotides encoding Cds1 polypeptidese and methods for modulating cell cycle progression in a cell.
    Type: Application
    Filed: May 4, 2001
    Publication date: July 4, 2002
    Inventors: Zijian Guo, William G. Dunphy
  • Method for identifying a reagent that modulates Myt1 activity
    Patent number: 6387642
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Grant
    Filed: April 30, 2001
    Date of Patent: May 14, 2002
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai, William G. Dunphy
  • METHOD FOR IDENTIFYING A REAGENT THAT MODULATES MYT1 ACTIVITY
    Publication number: 20020016444
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Application
    Filed: April 30, 2001
    Publication date: February 7, 2002
    Applicant: California Institute of Technology, a California corporation
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko kumagai, William G. Dunphy
  • Isolated Myt1 polypeptide
    Patent number: 6225101
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Grant
    Filed: June 21, 1999
    Date of Patent: May 1, 2001
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai, William G. Dunphy
  • DNA encoding a Myt1 polypeptide
    Patent number: 6020194
    Abstract: The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also included are polynucleotides encoding Myt1 polypeptide and antibodies that bind to Myt1. Methods of modulating Myt1 for preventing premature entry of the cell into mitosis or to accelerate entry into mitosis are also provided, as are methods for identifying agents that modulate Myt1.
    Type: Grant
    Filed: October 1, 1997
    Date of Patent: February 1, 2000
    Assignee: California Institute of Technology
    Inventors: Paul R. Mueller, Thomas R. Coleman, Akiko Kumagai, William G. Dunphy