Abstract: The present invention is directed to methods for treatment of malignancies in companion animals employing dianhydrogalactitol, diacetyldianhydrogalactitol, and dibromodulcitol, as well as analogs and derivatives thereof, in addition to a method to improve the efficacy and/or reduce the side effects of the administration of a therapeutic agent selected from the group consisting of dianhydrogalactitol, a derivative of dianhydrogalactitol, diacetyldianhydrogalactitol, a derivative of diacetyldianhydrogalactitol, dibromodulcitol, and a derivative of dibromodulcitol to a veterinary subject, the method comprising the steps of: (1 (identifying at least one factor or parameter associated with the efficacy and/or occurrence of side effects of the administration of the therapeutic agent to the veterinary subject; and (2) modifying the factor or parameter to improve the efficacy and/or reduce the side effects of the administration of the therapeutic agent to the veterinary subject.

Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract. Also disclosed are novel mercaptan compounds, particularly those including a photolabile protecting group, as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

Abstract: Methods of treating ocular diseases using dithiol compounds, their derivatives, and pharmaceutically acceptable salts thereof are disclosed. In particular, methods using dithiol compounds that comprise derivatives of lipoic acid are described. The dithiol compounds are especially useful for treating ocular diseases such as presbyopia and cataract.

Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

Abstract: Novel mercaptan compounds, particularly those including a photolabile protecting group, are described as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

Abstract: Compounds, formulations, and methods are provided containing the choline ester of a reducing agent, especially lipoic acid or derivatives thereof. The compounds may be administered via a topical ocular route to treat or prevent oxidative damage.

Abstract: Compositions containing low doses of lipoic acid-based active agents and methods for using the same are provided. In particular, compositions containing low dose lipoic acid, lipoic acid derivatives, and lipoic acid seleno-derivatives and are provided to prevent and/or treat ocular diseases.

Abstract: Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.

Abstract: Novel mercaptan compounds, particularly those including a photolabile protecting group, are described as well as methods of using the compounds for the prevention and treatment of ocular damage and disease.

Abstract: Improved intraocular irrigating solutions are described. The solutions have enhanced viscosities that reduce the risk of damage to intraocular tissues during intraocular surgical procedures by reducing the turbulence of the solutions and dampening the movement of tissue fragments and air bubbles. The solutions preferably also have modified surface tensions that more closely resemble the surface tension of the aqueous humor.

Abstract: A system and process for concentrating hydrocarbons in a bitumen feed comprising bitumen, water and solids. The system comprises an inclined plate separator, a hydrocarbon cyclone and a centrifuge. The inclined plate separator separates the bitumen feed into a first overflow stream and a first underflow stream, the first overflow stream having a first bitumen concentration greater than that of the first underflow stream. The hydrocarbon cyclone separates the first underflow stream into a second overflow stream and a second underflow stream. The centrifuge separates the second overflow stream into a third overflow stream and a third underflow stream, the third overflow stream having a third bitumen concentration that is greater than that of the third underflow stream.

Abstract: A system and method for authenticating the source of, protecting the contents of, and ensuring the integrity of information. The information may be any digital information which can be stored in a computer file. The information is encapsulated in a computer file which also includes the biometrically verified identity of the person who packaged the information. The contents of the computer file are encrypted, and a unique message digest value is generated and stored in a secure central database. The message digest value functions as the digital signature of the encrypted information, and is used to ensure the integrity of the information.

Abstract: An extraction system and process for extracting bitumen from a slurry containing bitumen, solids and water. The system comprises a cyclone separation facility for separating the slurry into a solids component stream and a bitumen froth stream with the bitumen froth stream including water and fine solids. The bitumen froth stream is then delivered to a froth concentration facility for separating the bitumen froth stream into a final bitumen enriched froth stream, and a water and fine solids stream. The final bitumen enriched froth stream is suitable for further processing. The system of the present invention is preferably mobile so that the cyclone extraction facility and the froth concentration facility can move with the mine face at an oil sands mining site, however, it is also contemplated that the system can be retrofitted to existing fixed treatment facilities to improve the operational efficiency of such fixed facilities.

Abstract: Discloses apparatus to perform a process to remove water and minerals from a bitumen froth output of a oil sands hot water extraction process. A bitumen froth feed stream is diluted with a solvent and supplied to a primary inclined plate separator stage, which separates the bitumen into an overflow stream providing a bitumen product output from the circuit and a bitumen depleted underflow stream. A primary cyclone state, a secondary inclined plate separator stage and a secondary cyclone stage further process the underflow stream to produce a secondary bitumen recovery product stream and a recycle stream. The secondary bitumen recovery product stream is incorporated into and becomes part of the circuit bitumen product output stream. The recycle stream is incorporated into the bitumen froth feed stream for reprocessing by the circuit.

Abstract: An apparatus for separating bitumen from a bitumen froth output of a oil sands hot water extraction process comprises an inclined plate separator (IPS) for providing a first bitumen separation stage and a cyclone for providing a second bitumen separation stage. The cyclone overflow is recycled to the IPS inlet.

Abstract: An apparatus to perform a process to remove water and minerals from a bitumen froth output of a oil sands hot water extraction process comprises: (i) a cyclone body having an elongated conical inner surface defining a cyclone cavity extending from an upper inlet region with a diameter DC to a lower apex outlet with a diameter DU; (ii) an inlet means forming an inlet channel extending into the upper inlet region of the cyclone cavity; and (iii) a vortex finder forming an overflow outlet of a diameter (DO) extending into the upper inlet region of the cyclone cavity toward the lower apex outlet and having a lower end extending an excursion distance below the inlet channel; wherein a fluid composition entering the inlet channel into the cyclone cavity is urged by force of gravity and velocity pressure downward toward the lower apex and variations in density of the constituent components of the fluid composition cause the lighter component materials to be directed toward the overflow outlet of the vortex finder.