Patents by Inventor William Geiss
William Geiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7435861Abstract: A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.Type: GrantFiled: May 1, 2006Date of Patent: October 14, 2008Assignee: Cardax Pharmaceuticals, Inc.Inventors: Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20080221377Abstract: A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.Type: ApplicationFiled: June 18, 2007Publication date: September 11, 2008Inventors: Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick, Cristi L. Braun
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Publication number: 20080064686Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.Type: ApplicationFiled: April 26, 2007Publication date: March 13, 2008Applicant: The Regents of the University of MichiganInventors: Manzer Durrani, William Geiss, David Fairfax, Dmytro Tymoshenko, Van-Duc Le, Lisa Peterson
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Publication number: 20070238747Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.Type: ApplicationFiled: May 17, 2007Publication date: October 11, 2007Applicant: ActivBiotics, Inc.Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Xiang Yu, James Siedlecki, Yingfei Yang
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Patent number: 7247752Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.Type: GrantFiled: October 3, 2005Date of Patent: July 24, 2007Assignee: Cardax Pharmaceuticals, Inc.Inventors: Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20070155715Abstract: The present invention features rifamycin analogs and methods of using these compounds to treat a variety of microbial infections.Type: ApplicationFiled: December 14, 2006Publication date: July 5, 2007Applicant: ActivBiotics, Inc.Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Joseph Raker, Xiang Yu, James Siedlecki, Yingfei Yang
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Publication number: 20060293545Abstract: A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.Type: ApplicationFiled: May 1, 2006Publication date: December 28, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060183947Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active astaxanthin derivatives.Type: ApplicationFiled: October 3, 2005Publication date: August 17, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060183185Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active unsaturated ketone intermediate from ketoisopherone. The optically active unsaturated ketone may be converted into optically active astaxanthin derivatives.Type: ApplicationFiled: October 3, 2005Publication date: August 17, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060178538Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intyermediate from ketoisopherone.Type: ApplicationFiled: October 3, 2005Publication date: August 10, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060167319Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active unsaturated ketone intermediate from ketoisopherone.Type: ApplicationFiled: October 3, 2005Publication date: July 27, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060155150Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active lutein.Type: ApplicationFiled: October 3, 2005Publication date: July 13, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060111580Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy ketone intermediate from ketoisopherone.Type: ApplicationFiled: October 3, 2005Publication date: May 25, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060088905Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy intermediate from ketoisopherone. The optically active dihydroxy intermediate may be converted into optically active zeaxanthin.Type: ApplicationFiled: October 3, 2005Publication date: April 27, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20060088904Abstract: A method used for synthesizing intermediates for use in the synthesis of carotenoids and carotenoid analogs, and/or carotenoid derivatives. In some embodiments, the invention includes methods for synthesizing optically active intermediates useful for the synthesis of optically active carotenoids. Synthesis of optically active carotenoids, in one embodiment, may be accomplished by forming an optically active dihydroxy ketone intermediate from ketoisopherone. The optically active dihydroxy ketone intermediate may be converted into optically active astaxanthin derivatives.Type: ApplicationFiled: October 3, 2005Publication date: April 27, 2006Inventors: Samuel Lockwood, Peng Tang, Geoff Nadolski, Henry Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
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Publication number: 20050197333Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?- and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.Type: ApplicationFiled: December 22, 2004Publication date: September 8, 2005Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Joseph Raker, Xiang Yu, James Siedlecki, Yingfei Yang
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Patent number: 6919379Abstract: Novel compounds of formula (I) wherein R1 represents hydrogen; R2 represents hydroxy, fluoro, or an oxo group; R3 represents hydrogen; R4 represents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereoisomers thereof, with the exception of the racemate of (3-amino-2-hydroxypropyl)sulphinic acid. The compounds are useful in therapy, especially for the treatment of reflux disease.Type: GrantFiled: June 4, 2002Date of Patent: July 19, 2005Assignee: AstraZeneca ABInventors: Kevin Fitzpatrick, William Geiss, Anders Lehmann, Gunnel Sundén, Sverker Von Unge
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Publication number: 20050137189Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, and/or various fused ring systems with the benzene ring at the 4?,5? or 5?,6? positions.Type: ApplicationFiled: December 9, 2004Publication date: June 23, 2005Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Xiang Yu, James Siedlecki, Yingfei Yang
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Publication number: 20050043298Abstract: The present invention features rifamycin analogs that can be used as therapeutics for treating or preventing a variety of microbial infections. In one form, the analogs are acetylated at the 25-position, as is rifamycin. In another form, the analogs are deacetylated at the 25-position. In yet other forms, benzoxazinorifamycin, benzthiazinorifamycin, and benzdiazinorifamycin analogs are derivatized at various positions of the benzene ring, including 3?-hydroxy analogs, 4?-and/or 6? halo and/or alkoxy analogs, and various 5? substituents that incorporate a cyclic amine moiety.Type: ApplicationFiled: August 11, 2004Publication date: February 24, 2005Inventors: John van Duzer, Arthur Michaelis, William Geiss, Douglas Stafford, Joseph Raker
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Publication number: 20040152775Abstract: Novel compounds of formula (I) wherein R1 represents hydrogen; R2 represents hydroxy, fluoro or an oxo group; R3 represents hydrogen; R4 represents hydrogen; and pharmaceutically acceptable salts, solvates and the stereoisomers thereof, with the exception of the racemate of (3-amino-2-hydroxypropyl)sulphinic acid. The compounds are useful in therapy, especially for the treatment of reflux disease. The invention is also related to processes for their preparation, intermediates of said process and pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.Type: ApplicationFiled: January 13, 2004Publication date: August 5, 2004Inventors: Kevin Fitzpatrick, William Geiss, Anders Lehmann, Gunnel Sunden, Sverker Von Unge