Patents by Inventor William Guthrie

William Guthrie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dehydroamino acids
    Patent number: 6515124
    Abstract: Aromatic dehydroamino acids are disclosed that are active as LFA-1 arnagonists This activity enables these compounds to prevent inflammation which is a consequence of T cell activation and accordingly reduce or eliminate inflammatory skin disease psoriasis.
    Type: Grant
    Filed: January 5, 2001
    Date of Patent: February 4, 2003
    Assignee: Hoffman-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • Dehydroamino acids
    Publication number: 20020161237
    Abstract: Compounds of formula 1 and 1-1, 1
    Type: Application
    Filed: January 5, 2001
    Publication date: October 31, 2002
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • N-alkanoylphenylalanine derivatives
    Patent number: 6455550
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: September 24, 2002
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achytharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Diaminopropionic acid derivatives
    Patent number: 6331640
    Abstract: A compound of formula 1a which is useful for treating reperfusion injury, and salts, prodrugs, and related compounds.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: December 18, 2001
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Nader Fotouhi, Paul Gillespie, Robert William Guthrie, Sherrie Lynn Pietranico-Cole, Weiya Yun
  • N-aroylphenylalanine derivative VCAM-1 inhibitors
    Patent number: 6229011
    Abstract: Compounds of the formula: are disclosed which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: May 8, 2001
    Assignee: Hoffman-La Roche Inc.
    Inventors: Li Chen, Robert William Guthrie, Tai-Nang Huang, Achyutharao Sidduri, Jefferson Wright Tilley, Kenneth Gregory Hull
  • Fuel injection system for internal combustion engines
    Patent number: 6047671
    Abstract: A method of lubricating and cleaning a fuel injector of a fuel injection system of an internal combustion engine during running of the engine including delivering both a lubricant and a cleaning additive to the injector. The injector injects directly into the combustion chamber of the engine. The lubricant and cleaning additive are delivered to the fuel exit area of the injector.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: April 11, 2000
    Assignee: Orbital Engine Company (Australia) Pty Limited
    Inventors: John Howard Tubb, Gavin Warran Dickson, David James Caley, Paul William Guthrie, Oswald Baasch
  • Taurine and glycine derivatives
    Patent number: 4104285
    Abstract: Taurine and glycine derivatives of nor or bisnorcholanic acid or etiocholanic acid which are useful in increasing bile flow or decreasing lipid levels and their method of production from deoxycholic acid, including intermediates thereof.
    Type: Grant
    Filed: April 22, 1977
    Date of Patent: August 1, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hugo Gallo-Torres, Robert William Guthrie, James Guthrie Hamilton, Richard Wightman Kierstead, Ann Clare Sullivan
  • Hydroxycitric acid derivatives
    Patent number: 4028397
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: June 7, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 4007208
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: February 8, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 4006166
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: February 1, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 4005086
    Abstract: Ester and amide derivatives of threo-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: January 25, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 3994927
    Abstract: Ester and amide derivatives of three-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 30, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 3993668
    Abstract: Ester and amide derivatives of three-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Hydroxycitric acid derivatives
    Patent number: 3993667
    Abstract: Ester and amide derivatives of three-hydroxycitric acid .gamma.-lactone inhibit fatty acid synthesis in biological systems and are useful in the treatment of obesity and in correcting conditions of lipid abnormalities.
    Type: Grant
    Filed: August 1, 1975
    Date of Patent: November 23, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • Citric acid derivatives
    Patent number: 3966772
    Abstract: Epoxyaconitic acid and esters thereof are useful for the control of lipogenesis.
    Type: Grant
    Filed: February 13, 1974
    Date of Patent: June 29, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, James Guthrie Hamilton, Richard Wightman Kierstead, O. Neal Miller, Ann Clare Sullivan
  • 7-Oxa steroids
    Patent number: 3962275
    Abstract: 7-Oxa steroids which may be substituted in the 3-position with a hydroxy or oxo group or in the 2-position with a hydroxymethylene group or in the 2- and 3-positions with a substituent that forms a 5-membered heterocyclic ring, useful as antigonadotropic agents and a method of preparing these 7-oxa steroids from 3-hydroxy .DELTA..sup.5 -steroids including intermediates in this process.
    Type: Grant
    Filed: December 11, 1974
    Date of Patent: June 8, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead, Ronald Andrew Lemahieu
  • Amino citric acid derivatives
    Patent number: 3960933
    Abstract: Amino citric acids and esters, and lactams thereof, are useful for the control of lipogenesis.
    Type: Grant
    Filed: December 16, 1974
    Date of Patent: June 1, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Robert William Guthrie, Richard Wightman Kierstead
  • 9-Acyloxy-5,11-dimethyl-6H-pyrido[4,3-B]carbazoles
    Patent number: 3933827
    Abstract: 9-Acyloxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazoles of the formula ##SPC1##Wherein R.sub.1 is acyl and R.sub.2 is hydrogen or lower alkyl, are described. The end products actively inhibit the growth of transplantable tumors, and are therefore useful as cytostatic agents.
    Type: Grant
    Filed: October 29, 1974
    Date of Patent: January 20, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arnold Brossi, Robert William Guthrie, Richard Wightman Kierstead