Patents by Inventor William H. Prusoff

William H. Prusoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Borinic acid protease inhibitors
    Publication number: 20030220267
    Abstract: The invention provides compounds of formula I: 1
    Type: Application
    Filed: February 11, 2003
    Publication date: November 27, 2003
    Inventors: Donald S. Matteson, Levente Fabry-Asztalos, William H. Prusoff, Arman Pivazyan
  • Use of 2',3'-dideoxycytidin-2'-ene (2'- ,3'-dideoxy-2'3'-didehydrocytidine) in treating patients infected with retroviruses
    Patent number: 6001818
    Abstract: This invention relates to the use of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) in treating patients infected with a retrovirus.
    Type: Grant
    Filed: July 3, 1991
    Date of Patent: December 14, 1999
    Assignee: Yale University
    Inventors: Tai-Shun Lin, William H. Prusoff
  • Intermediates in the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
    Patent number: 5099010
    Abstract: This disclosure describes the preparation of 3'-amino-2', 3'-dideoxyctidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.
    Type: Grant
    Filed: May 15, 1986
    Date of Patent: March 24, 1992
    Assignee: Research Corporation
    Inventors: Tai-Shun Lin, William H. Prusoff
  • Use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with retroviruses
    Patent number: 4978655
    Abstract: This invention relates to the use of 3'-deoxythymidin-2'-ene (3'deoxy-2',3'-didehydrothymidine) in treating patients infected with a retrovirus.
    Type: Grant
    Filed: December 17, 1986
    Date of Patent: December 18, 1990
    Assignee: Yale University
    Inventors: Tai-Shun Lin, William H. Prusoff
  • 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
    Patent number: 4710492
    Abstract: This invention relates to 3'-azido-2',3'-dideoxy-5-halouridine, particularly, 3'-azido-2', 3'-dideoxy-5-bromouridine and 3'-azido-2',3'-dideoxy-5-iodouridine, and its use in treating patients infected with a retrovirus.
    Type: Grant
    Filed: June 23, 1986
    Date of Patent: December 1, 1987
    Assignee: Yale University
    Inventors: Tai-Shun Lin, William H. Prusoff
  • 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof
    Patent number: 4604382
    Abstract: This disclosure describes the preparation of 3'-amino-2',3'-dideoxycytidine and the pharmacologically acceptable salts thereof which are useful in inhibiting the growth of transplanted tumors in mammals.
    Type: Grant
    Filed: January 17, 1983
    Date of Patent: August 5, 1986
    Assignee: Research Corporation
    Inventors: Tai-Shun Lin, William H. Prusoff
  • Compositions and method for alleviating the toxic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea
    Patent number: 4600573
    Abstract: This disclosure describes the preparation of therapeutically effective compositions of matter containing a nucleoside such as thymidine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) which are useful in inhibiting the growth of transplanted tumors in mammals.
    Type: Grant
    Filed: April 3, 1985
    Date of Patent: July 15, 1986
    Assignee: Research Corporation
    Inventors: Tai-Shun Lin, William H. Prusoff
  • Nitrosourea analogs of thymidine
    Patent number: 4128639
    Abstract: Alkyl and haloalkyl nitrosourea analogs of thymidine are useful in the treatment of cancers in mice.
    Type: Grant
    Filed: December 14, 1977
    Date of Patent: December 5, 1978
    Assignee: Research Corporation
    Inventors: Tai-Shun Lin, Paul H. Fischer, William H. Prusoff, George T. Shiau