Patents by Inventor William Hoekstra

William Hoekstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULE INHIBITORS OF BACTERIAL TOXINS
    Publication number: 20230357139
    Abstract: Described herein are compounds and compositions for use in treatment or prevention of an inflammatory bowel disease, gastrointestinal cancer, or a systemic bacterial infection in a subject in need thereof. The subject may be colonized by one or more pathogenic bacterial strains such as B. fragilis, E. faecalis, or C. perfringens. In certain aspects, the disclosure provides a method of diminishing the pathogenic effects of these bacterial strains by administering a compound that binds to and/or inhibits one or more toxins produced thereby.
    Type: Application
    Filed: September 13, 2021
    Publication date: November 9, 2023
    Inventors: William HOEKSTRA, Hyunji RYU, Priyanka CHINTHA
  • FUNGICIDAL COMPOSITIONS
    Publication number: 20160102072
    Abstract: The instant invention describes tetrazole compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
    Type: Application
    Filed: May 28, 2014
    Publication date: April 14, 2016
    Inventors: William Hoekstra, Michael R. Loso, Gary D. Gustafson, Daniel Knueppel, Zachary A. Buchan, Michael T. Sullenberger
  • METALLOENZYME INHIBITOR COMPOUNDS
    Publication number: 20150246898
    Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. Living organisms have developed tightly regulated processes that specifically import metals, transport them to intracellular storage sites and ultimately transport them to sites of use. One of the most important functions of metals such as zinc and iron in biological systems is to enable the activity of metalloenzymes.
    Type: Application
    Filed: September 12, 2013
    Publication date: September 3, 2015
    Inventors: Gary D. Gustafson, William Hoekstra, Michael R. Loso, Christopher M. Yates
  • Substituted Quinoline Compounds For Use As Selective Estrogen Receptor Modulator
    Publication number: 20070203180
    Abstract: The present invention relates to novel compounds of formula (I) with a variety of therapeutic uses, more particularly novel substituted quinoline compounds particularly useful for selective estrogen receptor modulation.
    Type: Application
    Filed: February 22, 2005
    Publication date: August 30, 2007
    Inventors: William Hoekstra, Aaron Miller, William Zuercher, Harikrishna Patel
  • Novel heteroaryl peptidomimetics as thrombin receptor antagonists
    Publication number: 20060009396
    Abstract: The invention is directed to novel heteroaryl peptidomimetic compounds which are useful as thrombin receptor antagonists for the treatment of diseases associated with thrombosis, restenosis, hypertension, heart failure, arrhythmia, inflammation, angina, stroke, atherosclerosis, ischemic conditions, angiogenesis and related disorders, cancer, and neurodegenerative disorders. Pharmaceutical compositions comprising the substituted heteroaryl peptidomimetics of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
    Type: Application
    Filed: September 15, 2005
    Publication date: January 12, 2006
    Inventors: Han-Cheng Zhang, Bruce Maryanoff, William Hoekstra, Kimberly White
  • Azole peptidomimetics as thrombin receptor antagonists
    Patent number: 6156732
    Abstract: Azole derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: December 5, 2000
    Assignee: Ortho-McNeil Pharmaceuticals, Inc.
    Inventors: William Hoekstra, Becky L. Hulshizer
  • Azole peptidomimetics as thrombin receptor antagonists
    Patent number: 6017890
    Abstract: Azole derivatives of formula (I): ##STR1## are disclosed as useful in treating platelet-mediated thrombotic disorders.
    Type: Grant
    Filed: February 8, 1999
    Date of Patent: January 25, 2000
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: William Hoekstra, Becky L. Hulshizer