Abstract: Methods and materials for treating a mammal having a congenital disease (e.g., a congenital heart disease such as congenital long QT syndrome) are provided herein. For example, this document provides methods and materials for generating and using nucleic acids to treat a mammal having a congenital disease, where the nucleic acids can suppress expression of mutant disease-related alleles in the mammal while providing a replacement cDNA that does not contain the disease-related mutation(s).

Abstract: Method and apparatus for performing point to point verification of devices in a SCADA system are provided. An intelligent electronic device (IED), having two modes of operation--normal and simulation--provides simulated IED data to a SCADA device on command. The IED is capable of continuing to perform its normal functions of monitoring a process under control during the simulation mode. The IED accepts simulation data either locally through a user interface or from a SCADA device over/through a communication port. The simulation data is then stored in a memory area of the IED. During simulation mode, the IED does not update the memory area but rather provides data from this area to a SCADA device on command.