Abstract: Techniques to facilitate communication between remote industrial assets are disclosed herein. In at least one implementation, a computing system provides a virtual private network (VPN) service for an industrial automation network of an industrial automation enterprise. The computing system communicates with a first gateway system to establish a first connection between a first industrial asset and the VPN service for the industrial automation network. The computing system also communicates with a second gateway system to establish a second connection between a second industrial asset and the VPN service for the industrial automation network, wherein the second industrial asset is located at a disparate location than the first industrial asset.

Abstract: Techniques to facilitate communication between remote industrial assets are disclosed herein. In at least one implementation, a computing system provides a virtual private network (VPN) service for an industrial automation network of an industrial automation enterprise. The computing system communicates with a first gateway system to establish a first connection between a first industrial asset and the VPN service for the industrial automation network. The computing system also communicates with a second gateway system to establish a second connection between a second industrial asset and the VPN service for the industrial automation network, wherein the second industrial asset is located at a disparate location than the first industrial asset.

Abstract: The present invention provides a method for identifying a target pair comprising i) an inhibitory chimeric antigen receptor (iCAR) or a protective chimeric antigen receptor (pCAR) capable of preventing or attenuating undesired activation of an effector immune cell, wherein the iCAR or pCAR target is directed to a target extracellular polymorphic epitope, and ii) an activating chimeric antigen receptor (aCAR), wherein the aCAR is directed to a target non-polymorphic cell surface epitope of a protein, as well as methods of making and use of such pairs in the treatment of cancer.

Abstract: Techniques to facilitate communication between remote industrial assets are disclosed herein. In at least one implementation, a computing system provides a virtual private network (VPN) service for an industrial automation network of an industrial automation enterprise. The computing system communicates with a first gateway system to establish a first connection between a first industrial asset and the VPN service for the industrial automation network. The computing system also communicates with a second gateway system to establish a second connection between a second industrial asset and the VPN service for the industrial automation network, wherein the second industrial asset is located at a disparate location than the first industrial asset.

Abstract: Techniques to facilitate communication between remote industrial assets are disclosed herein. In at least one implementation, a computing system provides a virtual private network (VPN) service for an industrial automation network of an industrial automation enterprise. The computing system communicates with a first gateway system to establish a first connection between a first industrial asset and the VPN service for the industrial automation network. The computing system also communicates with a second gateway system to establish a second connection between a second industrial asset and the VPN service for the industrial automation network, wherein the second industrial asset is located at a disparate location than the first industrial asset.

Abstract: The present invention provides an association between copy loss of SF3B1 in cancer and sensitivity to SF3B1 suppression. Cancer cells harboring partial SF3B1 copy-loss are more sensitive because they lack a reservoir of SF3b complex that protects cells with normal SF3B1 copy number from cell death upon SF3B1 suppression. The invention also provides methods for treating cancer, especially cancer with SF3B1 copy loss, by suppressing the expression or activity of SF3B1.

Abstract: An S cam assembly, includes an S cam member having a shank, the shank having a machined shank outer margin, a tubular bushing holder member disposable annular to the shank, and a single S cam bushing member disposable intermediate the shank machined shank outer margin and an inside margin of the bushing holder when the bushing holder is in the annular disposition relative to the shank.

Abstract: A stent alignment system includes an implantable stent and catheter that allows the ability to precisely control translational and rotational position in a vessel of the implantable stent and catheter.

Abstract: A support assembly for supporting a S cam, the S cam being an intermediary device between a brake actuator and a set of wheel brakes and is generally an elongate metal rod shank having an S-head at one end and a set of splines at the other end, the S-head having at least one arm for engaging a respective brake shoe, whereby rotation of the S cam in a first direction causes the at least one arm of the S-head act on the brake shoe to frictionally engage the brake shoe with a brake drum, the brake drum being affixed to a wheel, includes single bushing rotationally supporting the S cam. A method of supporting the S cam is further included.

Abstract: A support assembly for supporting a S cam, the S cam being an intermediary device between a brake actuator and a set of wheel brakes and is generally an elongate metal rod shank having an S-head at one end and a set of splines at the other end, the S-head having at least one arm for engaging a respective brake shoe, whereby rotation of the S cam in a first direction causes the at least one arm of the S-head act on the brake shoe to frictionally engage the brake shoe with a brake drum, the brake drum being affixed to a wheel, includes single bushing rotationally supporting the S cam. A method of supporting the S cam is further included.

Abstract: A transmitter/receiver supplies echo signals to an amplifying circuit incorporating an attenuator, whereby the circuit has a variable amplification factor tending to compensate for reducing magnitude of the amplitudes of the echo signals with distance of detected objects from the transmitter/receiver. The area of detection is divided into alternate active and inactive zones radiating outwardly from the transmitter/receiver, the amplified echo signals emanating from objects in the active zones during a given operating cycle are integrated and the total output is compared with the corresponding total for the preceding cycle.