Patents by Inventor William J. Issa

William J. Issa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of separating biopolymer conjugated molecules from unconjugated molecules
    Patent number: 8207298
    Abstract: The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
    Type: Grant
    Filed: May 1, 2009
    Date of Patent: June 26, 2012
    Assignee: Archemix Corp.
    Inventors: Paul Hatala, William J. Issa
  • Methods of Separating Biopolymer Conjugated Molecules From Unconjugated Molecules
    Publication number: 20090286955
    Abstract: The invention relates to methods for separating or purifying biopolymer conjugated molecules from unconjugated molecules. In particular, methods are described for purifying a PEGylated protein or oligonucleotide from an unPEGylated protein or oligonucleotide, respectively. The methods are quick and efficient separation methods because they do not require gradient chromatography, fractionation of an eluent or analysis of the eluted fractions. Further, the methods increase yield and purity of the biopolymer conjugated molecule.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 19, 2009
    Inventors: Paul Hatala, William J. Issa