Abstract: A cocktail shaker includes a top shaker cup and a bottom shaker cup. The top shaker cup is shaped and sized such that an upper end of the top shaker cup can be inserted into an upper end of the bottom shaker cup. The bottom shaker cup is pliable to establish a seal between the top shaker cup and the bottom shaker cup when the top shaker cup is inserted into the bottom shaker cup. Additionally, the bottom shaker cup may include a built-in strainer. The top shaker cup includes a plurality of collapsible sections, each of which may be collapsed to adjust the internal volume of the top shaker cup. In some embodiments, each collapsible section may define an equal internal volume.

Abstract: A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.

Abstract: A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.

Abstract: A vial-based system and method for handling and processing specimens of particulate matter-containing liquid directly in the vial. A processing assembly, which includes a stirrer and a particulate matter separation chamber, is releasably coupled to the inside of the vial cover. The processing assembly remains with the cover when the vial is opened to insert a specimen therein. Application of a particular external force to the closed vial detaches the processing assembly from the cover so that it remains in the vial, for access by automated or manual laboratory equipment, when the cover is subsequently removed.

Abstract: A digital image collection system and method includes an area scan camera that scans a region to obtain digital image data therefrom, the area scan camera having an optical scan axis. A specimen mounting unit receives a specimen that is mounted on a top surface thereof, for enabling the specimen to be scanned by the area scan camera. The top surface of the specimen mounting unit is slanted at an angle with respect to the area scan camera such that the optical scan axis is oblique to the top surface of the specimen mounting unit.

Abstract: An automated system and method for individually processing multiple specimens of particulate matter-containing liquid in respective containers. The containers are transported seriatim along a processing path to present them to, at least, a preprocessing apparatus (e.g., a mixing head), and then to a specimen acquisition apparatus, which removes preprocessed specimen fluid from the container for subsequent analytical testing or evaluation. Each apparatus is actuated in response to presentation of a container thereto so as to carry out its respective operation independently. An exemplary system can include, in sequential order, stations for container loading and unloading, container uncapping and cap disposal, specimen mixing, filter loading, specimen acquisition (e.g., by aspiration, and then slide printing), filter disposal, and container resealing.

Abstract: Method and system for obtaining a liquid sample from a particulate matter-containing liquid in, e.g., a specimen container. A receptacle is used that has an inlet and a chamber for collecting the liquid sample. A discharge passage accommodates upward flow of liquid from the container. The discharge passage preferably has an upper discharge port, and at least one intake submerged in the liquid in the container. A flow-metering passage prevents particulate matter above a predetermined size from passing into the receptacle chamber. Liquid transfer commences after the receptacle inlet is placed in liquid-tight communication with the discharge port. Operation of mechanized system also is disclosed, as well as an arrangement and method for handling multiple receptacles at a liquid transfer station.

Abstract: Apparatus and method for handling a container having a removable cover, e.g., a vial for holding a biological fluid specimen. The container may have therein an internal element that is releasably coupled to the cover, such as an assembly for processing the specimen in the container. The method involves applying an external force to the covered container sufficient to release the internal element from the cover, and then dislodging the cover from the container. The external force may be an acceleration force applied to the container, such as an impact force to the bottom of the container, or direct contact with the cover with sufficient force to deflect the cover inwardly. A vertically mounted pressing member and a movably mounted gripper can be used. The pressing member may act to eject the cover from the gripper after the container is clear of the gripper. The apparatus may be part of an automated system for processing multiple liquid-based specimens.

Abstract: A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall of the holder. The inner fluid pervious medium is of low fluidic impedance relative to the outer fluid pervious medium. The filter assembly is designed for use in a separation housing that defines two flow paths between inlet and outlet, one directly through the filter and the other around the periphery of the filter. The inlet portion of the housing has a central inlet in a radially sloped surface that faces the filter collection site. A movable suction head is adapted to cooperate with the housing and the filter assembly.

Abstract: A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall of the holder. The inner fluid pervious medium is of low fluidic impedance relative to the outer fluid pervious medium. The filter assembly is designed for use in a separation housing that defines two flow paths between inlet and outlet, one directly through the filter and the other around the periphery of the filter. The inlet portion of the housing has a central inlet in a radially sloped surface that faces the filter collection site. A movable suction head is adapted to cooperate with the housing and the filter assembly.

Abstract: Apparatus and method for handling a container having a removable cover, e.g., a vial for holding a biological fluid specimen. The container may have therein an internal element that is releasably coupled to the cover, such as an assembly for processing the specimen in the container. The method involves applying an external force to the covered container sufficient to release the internal element from the cover, and then dislodging the cover from the container. The external force may be an acceleration force applied to the container, such as an impact force to the bottom of the container, or direct contact with the cover with sufficient force to deflect the cover inwardly. A vertically mounted pressing member and a movably mounted gripper can be used. The pressing member may act to eject the cover from the gripper after the container is clear of the gripper. The apparatus may be part of an automated system for processing multiple liquid-based specimens.

Abstract: A filter assembly for separating and collecting a layer of particulate matter (e.g., cells) from a liquid containing the particulate matter (e.g., a biological fluid specimen). The filter assembly has a holder and contiguous inner and outer fluid pervious media. The outer fluid pervious medium is attached to the sidewall of the holder. The inner fluid pervious medium is of low fluidic impedance relative to the outer fluid pervious medium. The filter assembly is designed for use in a separation housing that defines two flow paths between inlet and outlet, one directly through the filter and the other around the periphery of the filter. The inlet portion of the housing has a central inlet in a radially sloped surface that faces the filter collection site. A movable suction head is adapted to cooperate with the housing and the filter assembly.

Abstract: Method and apparatus for mixing a specimen (e.g., a biological fluid specimen) in an upstanding container having an internal mixer with a cavity defined by an upstanding annular wall. The annular wall of the mixer is engaged by a movable holder, which is elevated along with the engaged mixer sufficiently to prevent contact of the mixer with the container during mixing. The mixer is then moved to mix the specimen. The holder, which may include an expanding collet that fits within the cavity of the mixer, preferably rotates the mixer to stir the specimen. When mixing is complete, the holder is disengaged from the mixer. A controller coordinates all actions of the holder.

Abstract: An system and method are disclosed for isolating and grounding a load device, where grounding only occurs after the voltage(s) on the load device have been reduced to acceptable levels. The system includes power and grounding contacts, a sensing device, and a control device. The power contact determines whether a power line is coupled to a terminal of the load. The grounding contact determines whether the terminal is coupled to ground. The sensing device is coupled to the terminal, and the control device communicates with the contacts and sensing device. Upon a signal being provided to the control device, the control device causes the power contact to decouple the terminal from the power line and, upon the sensing device determining that a condition has been met concerning the terminal, the control device causes the grounding contact to couple the terminal with ground and a system indication light to be illuminated.

Abstract: A system for electrically isolating and indicating electrical isolation of a machine including a plurality of relays which cooperate to, when electrical isolation is selected, ground voltage input lines to the machine thereby ensuring that no power is provided to the machine during operator access thereto.

Abstract: Method and apparatus for mixing a specimen (e.g., a biological fluid specimen) in an upstanding container having an internal mixer with a cavity defined by an upstanding annular wall. The annular wall of the mixer is engaged by a movable holder, which is elevated along with the engaged mixer sufficiently to prevent contact of the mixer with the container during mixing. The mixer is then moved to mix the specimen. The holder, which may include an expanding collet that fits within the cavity of the mixer, preferably rotates the mixer to stir the specimen. When mixing is complete, the holder is disengaged from the mixer. A controller coordinates all actions of the holder.

Abstract: An apparatus and method for monitoring main contacts and auxiliary contacts of a power contactor is disclosed. The apparatus includes four circuits, the first of which has an on state in which a coil of the contactor is energized, and an off state. The first circuit switches from the off state to the on state when a power source is electrically connected to the first circuit if an additional signal is also present, and then remains in the on state until the power source is disconnected. The second circuit prevents the additional signal from being received by the first circuit when the auxiliary contact is in a position indicating that one of the main contacts is welded. The third circuit causes the first circuit to be disconnected from the power source when the fourth circuit provides a signal indicating that one of the auxiliary contacts is welded.

Abstract: A method and apparatus for collecting a cell sample of desired concentration on a filter collection site from a biological liquid specimen in a container. Specimen liquid is moved through a filter while the volume rate of liquid flow through the filter is monitored. The monitored liquid flow rate is compared to a reference value, and liquid flow through the filter is terminated when the ratio of monitored liquid flow rate to the reference value reaches or exceeds a predetermined ratio value. The predetermined ratio value preferably is a function of the protocol for processing the specimen. An alternative method and apparatus relies on the rate of change of the measured weight of the container. This rate is compared to a reference value, and liquid flow through the filter is terminated when the rate of change diminishes to or below a predetermined value.

Abstract: A microscope slide cassette for use with specimen handling apparatus. A plurality of opposed pairs of shelves carried by the side walls of the cassette are adapted to support specimen slides by their ends in the cassette. The shelves have a top surface on which a specimen slide can rest, and a resilient bottom surface configured to pinch the slide below against the shelf below to frictionally retain the pinched slide in the cassette. The bottom surface may comprise a spring. An inclined shelf lead-in ramp guides slides during insertion. Drainage ports in the side walls above and/or below the shelves make the cassette well suited for use in staining baths. Two laterally spaced racks on the rear wall, vertically spaced indexing marks corresponding to each slide position, and a sensor window at each slide position make the cassette well-suited for use in automated slide cassette handling mechanisms. The cassette is stackable with others for compact storage.

Abstract: Method and apparatus for applying seals made of thin material to the open tops of containers, e.g., specimen containers for holding biological fluid that are processed automatically. A measured length of sealing material is advanced across and pressed against the top of the container to effect a seal. Depending on the type of sealing material used, sealing may be accomplished by application of pressure alone, by application of heat and pressure, or by application of ultrasonic energy and pressure. Excess sealing material optionally may be folded against the container sides by means of a folding member adapted to surround a container when the sealing head is lowered. Motor-driven rollers advance the sealing material, while a platen on a movably mounted sealing head presses the sealing material into engagement with the container.