Abstract: St. John's Wort has been indicated as a beneficial supplement to human diet. It has been traditionally provided as an extract, tincture, tea or capsule form, usually administered in amounts taken three times/day. It has been found that the manufacture of a tablet of this supplement material is a complex process, and that St. John's Wort extract is not amenable to wet tableting. A tablet which can be taken twice a day to provide a recommended supplemental level of St. John's Wort is described as comprising by weight of the tablet: 400 to 500 mg St. John's Wort extract as 57 to 75% by weight of the tablet, 1.0-5.0% by weight binder, 8-18% by weight dissolution regulator, up to 30% by weight filler, 0.2 to 5.0% by weight glidant, and 0.5 to 2.5% by weight lubricant/glidant. A process for manufacturing the tablet comprises the steps of a) mixing components comprising: 400 to 500 mg St. John's Wort extract as 57 to 75% by weight of the tablet, 1.0-5.

Abstract: An orally administered tablet comprising a therapeutic amount of a pharmaceutically acceptable salt of amiodarone (e.g., an acid salt of amiodarone such as amiodarone hydrochloride) is described. Other ingredients include a disaccharide which is preferably a reducing disaccharide, pregelatinized starch, and an alkali metal starch glycolate. The tablet preferably also comprises at least one of the following: a) 2 to 6% by weight stearic acid, b) less than 1% by weight magnesium stearate, c) 2 to 25% by weight of wet binder, and d) less than 0.1% by weight of silica gel.