Patents by Inventor William J. Welsh
William J. Welsh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220363649Abstract: The invention relates in one aspect to compounds, and compositions comprising such compounds, that can be used to treat and/or prevent pain in a subject. In certain embodiments, the subject is a mammal. In yet other embodiments, the mammal is human.Type: ApplicationFiled: June 10, 2021Publication date: November 17, 2022Inventors: Youyi Peng, William J. Welsh
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Patent number: 10851096Abstract: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.Type: GrantFiled: June 16, 2017Date of Patent: December 1, 2020Assignees: Rutgers, The State University of New Jersey, The Curators of the University of MissouriInventors: William J. Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Thomas Walter Comollo, Stanley G. Kimani, Kamlendra Singh
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Publication number: 20190127361Abstract: Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods using a compound of formula I.Type: ApplicationFiled: June 16, 2017Publication date: May 2, 2019Applicants: Rutgers, The State University of New Jersey, The Curators of the University of MissouriInventors: William J. Welsh, Raymond Birge, Vladyslav Kholodovych, Youyi Peng, Thomas Walter Comollo, Stanley G. Kimani, Kamlendra Singh
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Patent number: 8569350Abstract: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.Type: GrantFiled: February 23, 2012Date of Patent: October 29, 2013Assignee: Rutgers, The State University of New JerseyInventors: William J. Welsh, Youyi Peng, Xin Wang, Susan M. Keenan, Qiang Zhang, Sonia Arora
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Patent number: 8486987Abstract: Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV.Type: GrantFiled: November 16, 2008Date of Patent: July 16, 2013Assignees: University of Medicine and Dentistry of New Jersey, Philadelphia Health and Education CorporationInventors: William J. Welsh, Sandhya Kortagere, Lawrence W. Bergman, Akhil B. Vaidya
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Patent number: 8455537Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O) (C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.Type: GrantFiled: June 21, 2011Date of Patent: June 4, 2013Assignee: University of Medicine and Dentistry of New JerseyInventors: William J. Welsh, Ching Y. Wang, Ni Ai
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Patent number: 8329149Abstract: The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.Type: GrantFiled: December 22, 2010Date of Patent: December 11, 2012Assignee: Avon Products, Inc.Inventors: John W. Lyga, Uma Santhanam, William J. Welsh
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Patent number: 8211882Abstract: The present invention discloses methods of modulating the activity of Group I mGluRs using a defined class of benzamide compounds. In one embodiment, methods of modulating the activity of mGluR1 are provided. In another embodiment, methods of modulating the activity of mGluR5 are provided. In still another embodiment, methods of simultaneously modulating the activities of both mGluR1 and mGluR5 are provided. The present invention also provides methods of treating diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of benzamide compounds. The present invention further provides methods of preventing diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of compounds.Type: GrantFiled: March 6, 2009Date of Patent: July 3, 2012Inventors: Richard Delarey Wood, William J Welsh, Sean Ekins, Ni Ai
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Publication number: 20120149744Abstract: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.Type: ApplicationFiled: February 23, 2012Publication date: June 14, 2012Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventors: William J. Welsh, Youyi Peng, Xin Wang, Susan M. Keenan, Qiang Zhang, Sonia Arora
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Patent number: 8200439Abstract: Methods related to the generation of shape signatures representing molecular shape, and using shape signatures in both ligand-based and receptor-based molecular design. Ray-tracing is used to explore the volume interior to a ligand, or the space exterior to a receptor site. Shape signatures are then probability distributions derived from the ray-traces. Shape signatures provide condensed descriptors of shape properties readily compared to each other to test for shape similarity or complementarity.Type: GrantFiled: October 14, 2010Date of Patent: June 12, 2012Inventors: Randy J. Zauhar, William J. Welsh
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Patent number: 8188128Abstract: Opioid receptor compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a condition mediated by an opioid receptor by administering an effective amount of the opioid receptor compound to a patient in need thereof.Type: GrantFiled: May 12, 2006Date of Patent: May 29, 2012Assignee: The University of Medicine and Dentistry of New JerseyInventors: William J. Welsh, Youyi Peng, Qiang Zhang, Susan M. Keenan, Sonia Arora
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Patent number: 8143299Abstract: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.Type: GrantFiled: October 25, 2005Date of Patent: March 27, 2012Assignee: University of Medicine and Dentistry of New JerseyInventors: William J. Welsh, Youyi Peng, Xin Wang, Susan M. Keenan, Qiang Zhang, Sonia Arora
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Patent number: 8140311Abstract: Methods related to the generation of shape signatures representing molecular shape, and using shape signatures in both ligand-based and receptor-based molecular design. Ray-tracing is used to explore the volume interior to a ligand, or the space exterior to a receptor site. Shape signatures are then probability distributions derived from the ray-traces. Shape signatures provide condensed descriptors of shape properties readily compared to each other to test for shape similarity or complementarity.Type: GrantFiled: October 10, 2007Date of Patent: March 20, 2012Inventors: Randy J. Zauhar, William J. Welsh
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Publication number: 20120003168Abstract: The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.Type: ApplicationFiled: December 22, 2010Publication date: January 5, 2012Applicant: Avon Products, Inc.Inventors: John W. Lyga, Uma Santhanam, William J. Welsh
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Patent number: 7989487Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O)(C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.Type: GrantFiled: July 6, 2007Date of Patent: August 2, 2011Assignee: University of Medicine and Dentistry of New JerseyInventors: William J. Welsh, Nina Ching Y. Wang, Ni Ai
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Publication number: 20110172268Abstract: Methods for preventing or treating an Apicomplexan parasite infection in a patient administering to a patient in need thereof an effective amount of a compound of Formulas I-IV.Type: ApplicationFiled: November 16, 2008Publication date: July 14, 2011Applicants: University of Medicine and Dentistry of New Jersey, Philadelphia Health And Education Corporation D/b/a Drexel University College of MedicineInventors: William J. Welsh, Sandhya Kortagere, Lawrence W. Bergman, Akhil B. Vaidya
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Publication number: 20110066384Abstract: Methods related to the generation of shape signatures representing molecular shape, and using shape signatures in both ligand-based and receptor-based molecular design. Ray-tracing is used to explore the volume interior to a ligand, or the space exterior to a receptor site. Shape signatures are then probability distributions derived from the ray-traces. Shape signatures provide condensed descriptors of shape properties readily compared to each other to test for shape similarity or complementarity.Type: ApplicationFiled: October 14, 2010Publication date: March 17, 2011Inventors: Randy J. Zauhar, William J. Welsh
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Patent number: 7776898Abstract: The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.Type: GrantFiled: September 18, 2007Date of Patent: August 17, 2010Assignee: The Curators of the University of MissouriInventors: William J. Welsh, Seong Jae Yu, Anil Nair
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Publication number: 20100152271Abstract: A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C?O)(C1-7)alkyl; Ra is (C1-7)alkyl or (C?O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.Type: ApplicationFiled: July 6, 2007Publication date: June 17, 2010Applicant: UNIVERSIT OF MEDICINE AND DENISTRY OF NEW JERSEYInventors: William J. Welsh, Nina Ching Y. Wang, Ni Ai
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Publication number: 20090317440Abstract: Substituted triazole compounds and pharmaceutical compositions thereof are presented. Also presented are methods for treating a pathology linked to a hyperproliferative disorder by administering the substituted triazole compounds to a patient in need thereof.Type: ApplicationFiled: October 25, 2005Publication date: December 24, 2009Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEYInventors: William J. Welsh, Youyi Peng, Xin Wang, Susan M. Keenan, Qiang Zhang, Sonia Arora