Abstract: A catalyst has a modified silica support and comprises a modifier metal, zirconium and/or hafnium, and a catalytic metal on the modified support. The catalyst has at least a proportion, typically, at least 25%, of modifier metal present in moieties having a total of up to 2 modifier metal atoms. The moieties may be derived from a monomeric and/or dimeric cation source. A method of production:— provides a silica support with isolated silanol groups with optional treatment to provide isolated silanol groups (—SiOH) at a level of <2.5 groups per nm2; contacting the optionally treated silica support with a monomeric zirconium or hafnium modifier metal compound to effect adsorption onto the support; optionally calcining the modified support for a time and temperature sufficient to convert the monomeric zirconium or hafnium compound adsorbed on the surface to an oxide or hydroxide of zirconium or hafnium in preparation for catalyst impregnation.

Abstract: The present disclosure provides compositions and methods for intra-articular delivery of anti-CSF1R antibodies to a tissue that is impacted by a disease that is treatable with CSF1/CSF1R inhibition and/or that expresses CSF1R. It was conventional knowledge that the intra-articular dwell time of proteins in joints is typically a few hours or less. The present disclosure shows, however, that intra-articular delivery of an anti-CSF1R antibody can lead to sustained exposure and pharmacologic activity of the antibody in the joints far beyond a few hours, providing an effective means for targeted and extended delivery of the therapeutic agent.

Abstract: A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection.

Abstract: A system for visualization and quantification of ultrasound imaging data according to embodiments of the present disclosure may include a display unit, and a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to estimate axial and lateral velocity components of the fluid flowing within the bodily structure, determine a plurality of flow directions within the image based on the axial and lateral velocity components, differentially encode the flow directions based on flow direction angle to generate a flow direction map, and cause the display unit to concurrently display the image including the bodily structure overlaid with the flow direction map.

Abstract: Methods, systems, and devices supporting virtual cryptographic key ceremonies are described. A server may receive a plurality of public keys and a plurality of digital signatures comprising data encrypted using a plurality of private keys, where each private key of the plurality of private keys corresponds to a respective public key of the plurality of public keys. The server may generate a quorum token based on the plurality of signatures and the plurality of public keys, where generating the quorum token is based on the plurality of signatures representing at least a threshold number of pools. The server may receive a plurality of encrypted shares associated with respective pools of a plurality of pools, generate a master wrapping key based on generating the quorum token and receiving the plurality of encrypted shares, unwrap a root key using the master wrapping key, and generate a certificate based on the root key.

Abstract: Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

Abstract: Cooling blankets for humans and animals including a plurality of chambers containing phase change material. The panels include upper and lower layers of weldable material with a plurality of linear welds connecting them and forming PCM chambers which extend across the panels in a generally linear, side-by-side arrangement. The panels further include fastener elements to connect adjacent panels and form a larger blanket. The shape and configuration of the panels and the PCM chambers allows them to be rolled for easy transportation and for charging.

Abstract: A method for preparing a product includes combining starting materials including A) a siloxane oligomer having silicon bonded hydrogen atoms, B) an alkoxysilane having at least one aliphatically unsaturated group capable of undergoing hydrosilylation reaction and C) a cobalt catalyst. The method can be used to produce a compound of formula (I). This compound can be used in a hydrosilylation reaction with a vinyl-functional polyorganosiloxane. The resulting product includes an ethyltrimethoxysilyl functional polyorganosiloxane useful in condensation reaction curable sealant compositions.

Abstract: A method of power Doppler imaging may include receiving a plurality of temporally sequential frames of wall-filtered power Doppler signals, wherein the plurality of temporally sequential frames includes at least one previously adjusted output frame. The method may further include adjusting at least one of the plurality of temporally sequential frames to produce an adjusted output frame and generating a power Doppler image based, at least in part, on the adjusted output frame. The adjusting may involve filtering the plurality of temporally sequential frames to suppress the high spatial frequency and high temporal frequency content to produce the adjusted output frame.

Abstract: There is set forth herein, in one embodiment, receiving, by a transceiver of a UE device an aggregate signal stream, the aggregate signal stream including an aggregate of base station downlink signal streams from a plurality of base stations; processing the aggregate signal stream and detecting, from the processing of the aggregate signal stream, a set of base stations in communication range of the UE device, wherein the set of base stations include a current serving base station and a scanning base station; determining, from the processing of the aggregate signal stream, a Doppler shifted center frequency of a downlink scanning signal stream received from the scanning base station; and enhancing, in dependence on the Doppler shifted center frequency, the downlink scanning signal stream associated to the scanning base station.

Abstract: The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies are able to initiate reversible gelation of hyaluronic acid (HA) by creating a depot that dissociates over time to release the antibody without any impact on its physical and chemical properties as well as its biological activity. As certain tissues and organs, such as eyes, joints and skins, contain HA, local injection of the antibodies to these tissues or organs will result in embedding of the antibody in gel formed from the HA, which becomes a repository of slow-released antibodies. In addition, slow-released formulations can be prepared with antibodies mixed with HA, optionally with other polymers.

Abstract: A silicone-polyether copolymer has the formula (X-D2)g-Y, where each X is an independently selected silicone moiety having a particular structure, D2 is a divalent hydrocarbon group, subscript g is greater than 1, and Y is a linear or branched polyether moiety. A method of preparing the silicone-polyether copolymer comprising reacting a polyether compound and an organosilicon compound in the presence of a hydrosilylation-reaction catalyst. A sealant is also disclosed, the sealant comprising the silicone-polyether copolymer and a condensation-reaction catalyst.

Abstract: Provided are high concentration stable formulations of anti-CSF1R/CSF1 antibodies. An example formulation includes 105 to 250 mg/mL of the antibody, 100 mM to 200 mM of arginine glutamate or arginine HCl, 10 mM to 50 mM histidine, and 0.015 to 0.035 w/v % of polysorbate 80, at a pH of 5.4 to 5.6. Also provided are methods of using the formulations for treating diseases.

Abstract: A system includes a generator configured to be electrically coupled to a grid, an engine configured to drive the generator, and a solid state generator coupled between the grid and an energy storage device. The system further includes a bias controller configured to detect a frequency of the grid and to responsively provide a bias signal to a speed controller of the engine. The bias controller may include a frequency bias controller configured to generate a frequency bias load sharing signal responsive to the detected frequency of the grid and a load sharing controller that receives the frequency bias load sharing signal and that generates the bias signal responsive to the load sharing signal.

Abstract: The invention discloses a catalyst comprising a silica support, a modifier metal and a catalytic alkali metal. The silica support has a multimodal pore size distribution comprising a mesoporous pore size distribution having an average pore size in the range 2 to 50 nm and a pore volume of said mesopores of at least 0.1 cm3/g, and a macroporous pore size distribution having an average pore size of more than 50 nm and a pore volume of said macropores of at least 0.1 cm3/g. The level of catalytic alkali metal on the silica support is at least 2 mol %. The modifier metal is selected from Mg, B, Al, Ti, Zr and Hf. The invention also discloses a method of producing the catalyst, a method of producing an ethylenically unsaturated carboxylic acid or ester in the presence of the catalyst, and a process for preparing an ethylenically unsaturated acid or ester in the presence of the catalyst.

Abstract: The present disclosure describes systems and methods for determining if a feature of interest is present in a volume or plane scanned by an imaging system. In examples, one or more imaging planes are analyzed for anatomical landmarks to determine whether a feature of interest is present. If the feature of interest is present, scan parameters may be determined to scan an adjusted volume that includes the feature of interest. In some applications, the adjusted volume may allow the imaging system to increase a volume rate.

Abstract: A system according to the present disclosure may include a display unit, a processor communicatively coupled to the display unit and to an ultrasound imaging apparatus for generating an image from ultrasound data representative of a bodily structure and fluid flowing within the bodily structure. The processor may be configured to generate vector field data including axial and lateral (or transverse) velocity components of the fluid flowing within the bodily structure, calculate velocity profiles for a plurality of locations along a wall of the bodily structure based on the axial and lateral velocity components, generate wall shear stress (WSS) visualization data based, at least in part, on the velocity profiles, and cause the display unit to concurrently display the image including the bodily structure overlaid with the WSS visualization data.

Abstract: A LED safety light for a snowmobile helmet is provided. The LED safety light includes a RCA male connector, a RCA female connector, and a LED light strip configured to attach to an outer surface of the snowmobile helmet. A double layered junction block includes an outer cover and an inner cover housing a PCB and at least a portion of the RCA female connector. The outer cover completely encapsulates the inner cover, wherein the junction block is configured to attach to the outer surface the snowmobile helmet. The RCA female connector is configured to be electrically connected to an auxiliary power output port of a snowmobile to provide power for the LED safety light and the RCA male connector is configured to electrically connect to a power input of a heated shield power input of the snowmobile helmet.

Abstract: The present disclosure provides compositions and methods for extended release of certain types of antibodies in vivo. It was discovered that such antibodies are able to initiate reversible gelation of hyaluronic acid (HA) by creating a depot that dissociates over time to release the antibody without any impact on its physical and chemical properties as well as its biological activity. As certain tissues and organs, such as eyes, joints and skins, contain HA, local injection of the antibodies to these tissues or organs will result in embedding of the antibody in gel formed from the HA, which becomes a repository of slow-released antibodies. In addition, slow-released formulations can be prepared with antibodies mixed with HA, optionally with other polymers.