Abstract: Methods of treating pruritus, including cholestatic pruritus, particularly cholestatic pruritus in primary biliary cholangitis comprising administration of the compound or a pharmaceutically acceptable salt thereof, are disclosed.

Abstract: According to one embodiment of the invention, a high-velocity fluid discharge device includes tubing having one or more orifices formed therein, a shroud coupled to the tubing such that, when a fluid flowing through the tubing exits the orifices, the fluid impinges on an inside surface of the shroud, and openings at both ends of the shroud. The openings have substantially the same areas.

Abstract: An apparatus for rotating a threaded tightening device includes a guide and an anvil utilized to impact a lug on the threaded tightening device to rotate the tightening device onto or off of a threaded member. The guide has a frame with a support sleeve attached thereto. A reciprocating device is received in and is supported by the support sleeve. The anvil is attached to the reciprocating device. When the reciprocating device is received in and is supported by the support sleeve, actuation of the reciprocating device will cause the anvil to repeatedly impact a lug to rotate the threaded tightening device in the desired direction.

Abstract: A separator float has a generally cylindrical body and a water swellable band having a selected outer diameter fitted circumferentially around a portion of the generally cylindrical body. The water swellable band is made of a water swellable material so that upon being exposed to water the water swellable band swells to a greater outside diameter. The separator float is preferably used in a blood collection tube and has a specific gravity between specific gravities of a light phase and a heavy phase of the blood. After the blood has been collected and centrifuged the separator float moves to a position between the light phase and the heavy phase and the water swellable band is exposed to water in the blood causing the band to swell and create a seal. Thereafter, the serum or plasma as well as white blood cells, lymphocytes, monocytes and platelets can be removed from the blood collection tube.

Abstract: An automatic filling micropipette is formed from a tubular body having an open end, and being closed or having a piston at an opposite end. The tubular body is sized to permit liquid to flow into the tubular body by capillary action. An aperture is provided in the sidewall, the aperture having a diameter smaller than the diameter of the open end.

Abstract: A tube for collection, separation and dispensation of a two-phase fluid is provided with a elongated rigid tubular container having a fluid entry end a closable end and a float. The float retained within the tubular container is positioned between the light phase and the heavy phase of the fluid on centrifugation thereby separating the two phases. In dispensing the light phase, the float moves to and engages the fluid entry end thereby preventing the heavy phase from escaping out of the tube.