Abstract: A passive magnetic constant-force apparatus comprises a geometry and arrangement of permanent magnets, ferromagnetic components, and non-magnetic structural components. The apparatus is easily and precisely adjustable, cost-effective, with a high load capacity, and with minimal parasitic forces. The apparatus is suitable for use as a counterbalance for vertical linear motion applications and may be integrated with or attached to a linear motion stage.

Abstract: The present disclosure provides methods of using compositions tliat inhibit SH2-containing inositol 5?-pliospliatases (SHIPs) for activating microglial cells, as well as methods for using such compositions for treatment or ameliorating of neurodegenerative disorders in a subject.

Abstract: The present invention refers to the medical field. Particularly, it refers to SHIP-1 inhibitors for use in enhancing the non-specific response of trained innate immune cells (i.e. enhancing the training of the innate immune cells) in a subject, wherein the SHIP-1 inhibitor is administered before, after or simultaneously to a treatment with a stimulus responsible for training the innate immune cells.

Abstract: The present invention relates to the use of SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation, a method of inhibiting SHIP to induce broad activation of natural killer (NK) cells to treat various diseases.

Abstract: The present invention relates to the use SHIP inhibitors to induce expression of granulocyte colony stimulating factor (G-CSF) in a subject, thereby promoting expansion of hematopoietic and mesenchymal stem cells. The present invention generally relates to new uses of SHIP inhibitors for therapeutic purposes. More particularly, the present invention relates to the use of SHIP inhibitors, including, without limitation, SHIP and/or pan-SHIP1/2 inhibitors, for the inhibition of SHIP to induce expression of granulocyte colony stimulating factor (G-CSF) to treat various-diseases or conditions.

Abstract: The present invention relates to the use or SHIP1 inhibitors and pan-SHIP1/2 inhibitors in various methods, including, without limitation, a method of inhibiting SHIP to induce broad activation of natural killer (NK) cells to treat various diseases.

Abstract: The present invention relates to the use SHIP inhibitors to induce expression of granulocyte colony stimulating factor (G-CSF) in a subject, thereby promoting expansion of hematopoietic and mesenchymal stem cells.

Abstract: Inhibition of dendritic cell function in solid organ grafts or allogeneic bone marrow transplants prior to or during engraftment by blocking SH2-containing inositol phosphatase (SHIP) expression or function is taught as a method of abrogating immune rejection and thereby increasing the efficacy of engraftment of an allogeneic bone marrow transplant or solid organ allograft or xenograft. Also disclosed is a transgenic mouse having the genotype SHIP?/? which exhibits enhanced survival following mismatched allogeneic marrow grafts.

Abstract: An animal containment system for use in housing animals, the animal containment system including a floor pan disposed in a first plane, first and second end walls, each said end wall oppositely disposed from each other and including a bottom edge and a top edge, a back wall including a bottom edge and a top edge, two doors, each including a bottom edge and a top edge, oppositely disposed from the back wall arranged to cover the open front portion of said animal containment system, a top panel oppositely disposed from the floor pan, a shelf disposed in between the floor pan and top panel, a wire ladder extending between the floor pan and said shelf, and a wheel base assembly comprising a base panel, four support tubes and at least four removable caster wheels.

Abstract: SH2 containing inositol 5?-phosphate (SHIP) modulates the activation of immune cells after recruitment to the membrane by Shc and the cytoplasmic tails of receptors. A novel SHIP isoform of approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described. It was found that s-SHIP is expressed in totipotent embryonic stem cells to the exclusion of the 145-kd SHIP isoform expressed in differentiated hematopoietic cells. s-SHIP is also expressed in primitive hematopoietic stem cells, but not in lineage-committed hematopoietic cells. In embryoic stem cells, s-SHIP partners with the adapter protein Grb2 without tyrosine phosphorylation and is present constitutively at the cell membrane. It is postulated that s-SHIP modulates the activation threshold of primitive stem cell populations.

Abstract: Methods and devices for repelling insects are disclosed. The methods and devices provide personal protection from insect bites and insect landings, particularly mosquito bites. The methods and devices employ insect repellents such as pyrethroids at low (parts per billion) levels. The methods and devices effectively minimize the number of mosquitoes landing on a subject properly using the devices.

Abstract: Methods and devices for repelling insects are disclosed. The methods and devices provide personal protection from insect bites and insect landings, particularly mosquito bites. The methods and devices employ insect repellents such as pyrethroids at low (parts per billion) levels. The methods and devices effectively minimize the number of mosquitoes landing on a subject properly using the devices.

Abstract: The instant invention teaches the inhibition of SHIP expression, or function, for the increased efficacy of autologous stem cell transplants. In another embodiment, interference with SHIP function can be used to temporarily expand and mobilize the hematopoietic stem cell compartment to assist with leukapheresis, to promote hematopoietic recovery after myeloablation treatments, to deplete target stem cell clones (such a leukemic clones and other tumor stem cell types), and to deplete, or damage, the repopulating ability of the endogenous hematopoietic stem cell pool in order to allow transplanted hematopoietic stem cells to better home and engraft and to promote in vivo expansion and mobilization of other organ-specific stem cell populations (e.g., mesenchymal, mammary).

Abstract: A fluid grid system for use with filter systems and other fluid handling devices. Preferably, the fluid grid system is designed such that components thereof may be readily connected to each other without the use of clips or other fasteners. Further, the fluid grid system preferably allows components to be installed and held in place or removed merely by applying a sufficient force to a portion of the component.

Abstract: Methods and devices for repelling insects are disclosed. The methods and devices provide personal protection from insect bites and insect landings, particularly mosquito bites. The methods and devices employ insect repellents such as pyrethroids at low (parts per billion) levels. The methods and devices effectively minimize the number of mosquitoes landing on a subject properly using the devices.

Abstract: A highly flexible and scalable architecture implements a wide variety of protocol bridging, including ATM SARing (segmentation and reassembly) operations and related functions with single call granularity for network to telecom interface applications such as voice over Internet. A very small packet size minimizes packetization delay so that VOIP can be realized without expensive echo cancellation.

Abstract: A directional coupler sensor is provided for measuring the moisture content of a substrate, such as hair. The sensor incorporates a high frequency directional coupler having a pair of generally parallel plates defining a coupling gap therebetween. A high frequency signal generator generates an electromagnetic field across the gap with the substrate placed across the coupling gap. The coupled power relates to the moisture content of the substrate. A pressure sensor is provided to ensure that the desired compactness of the substrate across the coupling gap is achieved to obtain accurate, reliable and consistent results.

Abstract: A method allowing for the inexpensive automated construction of interconnections between circuit boards is provided. According to the present invention, printed circuit pins are inserted in a circuit board from the top (component side). Provided the heads of the pins are thin enough to lie beneath a solder stencil, the pins may be pre-installed on the circuit board and solder applied to the pins at the same time solder is applied to other regions of the board. Thus, known surface mount techniques may be employed to form solder connections between the pins and conductive traces on the circuit board, which facilitates the automation of the previously manual operation of soldering the printed circuit pins separately.

Abstract: A fluid grid system for use with filter systems and other fluid handling devices. Preferably, the fluid grid system is designed such that components thereof may be readily connected to each other without the use of clips or other fasteners. Further, the fluid grid system preferably allows components to be installed and held in place or removed merely by applying a sufficient force to a portion of the component.

Abstract: A device is provided for the measurement of the moisture content of a substrate. The device utilizes a high-Q LC circuit having a resonant frequency. The LC circuit utilizes a high-Q inductor and a capacitor. The device also utilizes a high frequency signal generator, operable to couple power to the capacitor, electrically coupled to the LC circuit and a fiber matrix modification unit. The resonant frequency of the LC circuit is changeable in response to the moisture content of the substrate placed within the fiber matrix modification unit and proximate to the capacitor.