Abstract: The invention relates generally to compositions and methods for conjugating antibodies and activatable antibodies, and methods of partially reducing antibodies and/or activatable antibodies prior to conjugation, e.g., thiol-based conjugation, with an agent, e.g., a therapeutic and/or diagnostic agent.

Abstract: A distributed database system for handling transactions from multiple client systems. A database node receives a request to execute a transaction from a first client, involving a record modification. This record has an associated check-and-set (CAS) value that changes with modifications. The record is sent to the first client, which identifies the CAS value. Similarly, a second client sends a request for another transaction, receives the record, and identifies the CAS value. One of these clients attempts to stage a mutation based on their transaction. This includes sending the previously received CAS value. The system checks for a CAS value mismatch, indicating a conflicting mutation from another transaction. If a mismatch is detected, the transaction attempt is aborted to prevent conflicts. Otherwise, the mutation is staged, and the CAS value is updated.

Abstract: The present disclosure relates to an anti-FcRn antibody or an antigen binding fragment thereof with improved stability and uses thereof. The anti-FcRn antibody or antigen binding fragment thereof binds to FcRn non-competitively with IgG and the like compared to the parent antibody, HL161AN, thereby having improved stability, such as reducing the production rate of aggregates while maintaining the biological activity of significantly reducing the amount of pathogenic autoantibodies in the blood. Therefore, it may be utilized more efficiently for the treatment of an autoimmune disease.

Abstract: A method and system for providing a user who places a telephone call on hold with a partial hold option. When a user places a first call on partial hold and picks up a second call, the user can still hear conversation and activity that occurs on the first call. For example a user participating in a conference call may receive a second call. The user can place the conference call on partial hold and pick up a second call (i.e. engage in a conversation on a second telephone call). However, the incoming channel to the conference call will remain active and the user will be able to hear, in the background, what is taking place in the conference call.